MX2013005200A - Derivados de acido hidroxamico y su so en el tratamiento de infecciones bacterianas. - Google Patents

Derivados de acido hidroxamico y su so en el tratamiento de infecciones bacterianas.

Info

Publication number
MX2013005200A
MX2013005200A MX2013005200A MX2013005200A MX2013005200A MX 2013005200 A MX2013005200 A MX 2013005200A MX 2013005200 A MX2013005200 A MX 2013005200A MX 2013005200 A MX2013005200 A MX 2013005200A MX 2013005200 A MX2013005200 A MX 2013005200A
Authority
MX
Mexico
Prior art keywords
hydroxymethyl
methyl
diinyl
buta
hydroxyamino
Prior art date
Application number
MX2013005200A
Other languages
English (en)
Spanish (es)
Inventor
Ramesh Kasar
James Bradley Aggen
Martin Sheringham Linsell
Qing Jane Lu
Dan Wang
Tim Church
Heinz E Moser
Phillip A Patten
Original Assignee
Achaogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achaogen Inc filed Critical Achaogen Inc
Publication of MX2013005200A publication Critical patent/MX2013005200A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MX2013005200A 2010-11-10 2011-11-04 Derivados de acido hidroxamico y su so en el tratamiento de infecciones bacterianas. MX2013005200A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41231110P 2010-11-10 2010-11-10
PCT/US2011/059280 WO2012154204A1 (en) 2010-11-10 2011-11-04 Hydroxamic acid derivatives and their use in the treatment of bacterial infections

Publications (1)

Publication Number Publication Date
MX2013005200A true MX2013005200A (es) 2013-06-28

Family

ID=46317476

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005200A MX2013005200A (es) 2010-11-10 2011-11-04 Derivados de acido hidroxamico y su so en el tratamiento de infecciones bacterianas.

Country Status (14)

Country Link
EP (1) EP2638006A1 (OSRAM)
JP (1) JP2014501716A (OSRAM)
KR (1) KR20140023869A (OSRAM)
CN (1) CN103298780A (OSRAM)
AR (1) AR083760A1 (OSRAM)
AU (1) AU2011367819A1 (OSRAM)
BR (1) BR112013011693A2 (OSRAM)
CA (1) CA2817211A1 (OSRAM)
EA (1) EA201390626A1 (OSRAM)
IL (1) IL226270A0 (OSRAM)
MX (1) MX2013005200A (OSRAM)
SG (1) SG190243A1 (OSRAM)
TW (1) TW201249786A (OSRAM)
WO (1) WO2012154204A1 (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101765585B (zh) 2007-06-12 2017-03-15 尔察祯有限公司 抗菌剂
EP2847162A1 (en) * 2012-05-09 2015-03-18 Achaogen, Inc. Antibacterial agents
EP2847168A1 (en) 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
EA030730B1 (ru) 2013-12-19 2018-09-28 Идорсиа Фармасьютиклз Лтд Антибактериальные производные 1h-индазола и 1h-индола
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
US9539305B1 (en) 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
EA201692305A1 (ru) 2014-05-16 2017-05-31 Актелион Фармасьютиклз Лтд. Антибактериальные хиназолин-4(3н)-оновые производные
BR112017010474A2 (pt) 2014-11-19 2017-12-26 Actelion Pharmaceuticals Ltd derivados antibacterianos de benzotiazol
JP6697466B2 (ja) 2014-12-16 2020-05-20 ノバルティス アーゲー ＬｐｘＣ阻害剤としてのイソオキサゾールヒドロキサム酸化合物
ES2961564T3 (es) 2016-04-25 2024-03-12 Univ Duke Derivados de benzoilglicina y métodos de preparación y uso de los mismos
HUE050796T2 (hu) 2016-06-14 2021-01-28 Novartis Ag (R)-4-(5-(ciklopropiletinil)izoxazol-3-il)-N-hidroxi-2-metil-2-(metilszulfonil)butánamid kristályos formája baktériumellenes szerként
TW201803847A (zh) 2016-06-23 2018-02-01 美商爾察禎有限公司 抗菌劑
EP3750881A4 (en) * 2018-02-10 2021-11-17 KBP Biosciences Co., Ltd. COMPOUND ACTING AS ANTIBIOTIC
CN110563611B (zh) * 2019-09-19 2021-02-02 中国医学科学院医药生物技术研究所 一种异羟肟酸类衍生物及其制备方法和应用
CN113957098A (zh) * 2021-09-13 2022-01-21 湖南工业大学 普罗威登斯属细菌菌株在制备二价锰氧化剂中的应用
CN116730870B (zh) * 2023-08-08 2023-10-13 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925659A (en) 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
WO1998018754A1 (en) 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
WO2000061134A1 (en) 1999-04-09 2000-10-19 British Biotech Pharmaceuticals Limited Antimicrobial agents
CA2512582C (en) 2003-01-08 2014-07-08 University Of Washington Antibacterial agents
DE102006032709A1 (de) 2006-07-14 2008-01-17 BSH Bosch und Siemens Hausgeräte GmbH Luftschallgedämmte Lebensmittelmühle
CN101209974A (zh) * 2006-12-31 2008-07-02 天津药物研究院 异羟肟酸类衍生物及其用途
CN101765585B (zh) 2007-06-12 2017-03-15 尔察祯有限公司 抗菌剂
WO2011005355A1 (en) * 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
BR112012026926B1 (pt) * 2010-04-20 2021-01-19 Taisho Pharmaceutical Co Ltd composto derivado de ácido hidroxâmico, e composição farmacêutica, inibidor de lpxc e agente antimicrobiano compreendendo o referido composto

Also Published As

Publication number Publication date
KR20140023869A (ko) 2014-02-27
IL226270A0 (en) 2013-07-31
EA201390626A1 (ru) 2013-12-30
EP2638006A1 (en) 2013-09-18
JP2014501716A (ja) 2014-01-23
BR112013011693A2 (pt) 2016-08-09
SG190243A1 (en) 2013-06-28
CA2817211A1 (en) 2012-11-15
CN103298780A (zh) 2013-09-11
TW201249786A (en) 2012-12-16
AR083760A1 (es) 2013-03-20
AU2011367819A1 (en) 2013-05-02
WO2012154204A1 (en) 2012-11-15

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