MX2013002199A - Derivados de furopiridina. - Google Patents
Derivados de furopiridina.Info
- Publication number
- MX2013002199A MX2013002199A MX2013002199A MX2013002199A MX2013002199A MX 2013002199 A MX2013002199 A MX 2013002199A MX 2013002199 A MX2013002199 A MX 2013002199A MX 2013002199 A MX2013002199 A MX 2013002199A MX 2013002199 A MX2013002199 A MX 2013002199A
- Authority
- MX
- Mexico
- Prior art keywords
- denotes
- phenyl
- furo
- mmol
- unsubstituted
- Prior art date
Links
- YRTCKZIKGWZNCU-UHFFFAOYSA-N furo[3,2-b]pyridine Chemical class C1=CC=C2OC=CC2=N1 YRTCKZIKGWZNCU-UHFFFAOYSA-N 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 298
- 238000011282 treatment Methods 0.000 claims abstract description 50
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- 230000009885 systemic effect Effects 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 398
- -1 phenoxy, benzyloxy Chemical group 0.000 claims description 381
- 239000000203 mixture Substances 0.000 claims description 87
- 150000003839 salts Chemical class 0.000 claims description 74
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 47
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 42
- 125000004432 carbon atom Chemical group C* 0.000 claims description 39
- 239000012453 solvate Substances 0.000 claims description 39
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 32
- 125000004076 pyridyl group Chemical group 0.000 claims description 27
- 125000001544 thienyl group Chemical group 0.000 claims description 25
- 239000002253 acid Substances 0.000 claims description 24
- 239000004480 active ingredient Substances 0.000 claims description 22
- 125000002541 furyl group Chemical group 0.000 claims description 22
- 125000002883 imidazolyl group Chemical group 0.000 claims description 22
- 125000001786 isothiazolyl group Chemical group 0.000 claims description 22
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 22
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- 125000003373 pyrazinyl group Chemical group 0.000 claims description 22
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 22
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 22
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 22
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- 125000000335 thiazolyl group Chemical group 0.000 claims description 22
- 125000001425 triazolyl group Chemical group 0.000 claims description 22
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- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 12
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- OZSWAEYPIVJXRX-UHFFFAOYSA-N 2,3-dihydropyrazolyl Chemical group [N]1C=C=C=N1 OZSWAEYPIVJXRX-UHFFFAOYSA-N 0.000 claims description 7
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10008928 | 2010-08-27 | ||
| PCT/EP2011/003831 WO2012025187A2 (en) | 2010-08-27 | 2011-07-29 | Furopyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013002199A true MX2013002199A (es) | 2013-03-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| MX2013002199A MX2013002199A (es) | 2010-08-27 | 2011-07-29 | Derivados de furopiridina. |
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| Country | Link |
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| US (1) | US9006440B2 (enExample) |
| EP (1) | EP2609100B1 (enExample) |
| JP (1) | JP5789300B2 (enExample) |
| KR (1) | KR20130108318A (enExample) |
| CN (1) | CN103052640B (enExample) |
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| AU (1) | AU2011295441B2 (enExample) |
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| MX (1) | MX2013002199A (enExample) |
| SG (1) | SG187956A1 (enExample) |
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| MY181439A (en) | 2011-02-28 | 2020-12-22 | Sunshine Lake Pharma Co Ltd | Substituted quinoline compounds and methods of use |
| CN104093722B (zh) * | 2012-02-09 | 2016-07-27 | 默克专利股份公司 | 作为TBK1和IKK抑制剂的呋喃并[3,2-b]-和噻吩并[3,2-b]吡啶衍生物 |
| EP2817313B1 (en) * | 2012-02-21 | 2016-09-07 | Merck Patent GmbH | Furopyridine derivatives |
| BR112015001528B1 (pt) | 2012-07-28 | 2020-12-22 | Calitor Sciences, Llc E Sunshine Lake Pharma Co., Ltd. | composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica |
| US8975282B2 (en) | 2012-07-28 | 2015-03-10 | Sunshine Lake Pharma Co., Ltd. | Substituted pyrazolone compounds and methods of use |
| CZ2014295A3 (cs) * | 2014-04-30 | 2015-10-14 | Masarykova Univerzita | Substituované furo[3,2-b]pyridiny pro použití jako léčiva |
| RU2018102685A (ru) * | 2015-06-29 | 2019-08-02 | Мерк Патент Гмбх | СОЕДИНЕНИЯ-ИНГИБИТОРЫ TBK/IKKε И ИХ ПРИМЕНЕНИЕ |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20240043427A1 (en) | 2020-05-01 | 2024-02-08 | Gilead Sciences, Inc. | Cd73 compounds |
| CA3264304A1 (en) | 2022-08-09 | 2024-02-15 | Merck Patent Gmbh | Furo pyrimidine derivates |
| WO2024033280A1 (en) | 2022-08-09 | 2024-02-15 | Merck Patent Gmbh | Furopyridin and furopyrimidin, inhibitors of pi4k, for use in the treatment of parasite infection and malaria |
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| JP3290666B2 (ja) * | 1995-06-07 | 2002-06-10 | ファイザー・インコーポレーテッド | 複素環式の縮合環ピリミジン誘導体 |
| US6187777B1 (en) * | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| US20020004511A1 (en) * | 2000-06-28 | 2002-01-10 | Luzzio Michael Joseph | Thiophene derivatives useful as anticancer agents |
| US7834024B2 (en) | 2007-03-26 | 2010-11-16 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| US20090118276A1 (en) * | 2007-11-02 | 2009-05-07 | Wyeth | Thienopyrimidines, thienopyridines, and pyrrolopyrimidines as b-raf inhibitors |
| UA100262C2 (uk) * | 2008-03-05 | 2012-12-10 | Метилген Інк. | Інгібітори активності протеїнтирозинкінази |
| KR20100132550A (ko) | 2008-04-16 | 2010-12-17 | 포톨라 파마슈티컬스, 인코포레이티드 | ｓｙｋ 또는 ＪＡＫ 키나제 억제제로서의 ２,６－디아미노-피리미딘－５－일－카르복스아미드 |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
-
2011
- 2011-07-29 SG SG2013013990A patent/SG187956A1/en unknown
- 2011-07-29 EA EA201300283A patent/EA201300283A1/ru unknown
- 2011-07-29 AU AU2011295441A patent/AU2011295441B2/en not_active Ceased
- 2011-07-29 WO PCT/EP2011/003831 patent/WO2012025187A2/en not_active Ceased
- 2011-07-29 MX MX2013002199A patent/MX2013002199A/es not_active Application Discontinuation
- 2011-07-29 CA CA2809333A patent/CA2809333C/en not_active Expired - Fee Related
- 2011-07-29 US US13/819,166 patent/US9006440B2/en not_active Expired - Fee Related
- 2011-07-29 BR BR112013004624A patent/BR112013004624A2/pt not_active IP Right Cessation
- 2011-07-29 KR KR20137007836A patent/KR20130108318A/ko not_active Withdrawn
- 2011-07-29 ES ES11738631T patent/ES2545352T3/es active Active
- 2011-07-29 JP JP2013525161A patent/JP5789300B2/ja not_active Expired - Fee Related
- 2011-07-29 EP EP11738631.8A patent/EP2609100B1/en not_active Not-in-force
- 2011-07-29 CN CN201180041050.9A patent/CN103052640B/zh not_active Expired - Fee Related
- 2011-08-26 AR ARP110103112 patent/AR082727A1/es unknown
-
2013
- 2013-02-21 IL IL224870A patent/IL224870A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL224870A (en) | 2016-05-31 |
| US20130225569A1 (en) | 2013-08-29 |
| CN103052640B (zh) | 2017-06-30 |
| EP2609100B1 (en) | 2015-06-24 |
| JP5789300B2 (ja) | 2015-10-07 |
| BR112013004624A2 (pt) | 2016-07-05 |
| WO2012025187A3 (en) | 2012-06-21 |
| JP2013536208A (ja) | 2013-09-19 |
| WO2012025187A2 (en) | 2012-03-01 |
| CA2809333C (en) | 2018-09-25 |
| AR082727A1 (es) | 2012-12-26 |
| KR20130108318A (ko) | 2013-10-02 |
| AU2011295441A1 (en) | 2013-04-11 |
| EP2609100A2 (en) | 2013-07-03 |
| ES2545352T3 (es) | 2015-09-10 |
| AU2011295441B2 (en) | 2015-04-09 |
| US9006440B2 (en) | 2015-04-14 |
| CA2809333A1 (en) | 2012-03-01 |
| CN103052640A (zh) | 2013-04-17 |
| SG187956A1 (en) | 2013-03-28 |
| EA201300283A1 (ru) | 2013-08-30 |
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