SG187956A1 - Furopyridine derivatives - Google Patents

Info

Publication number

SG187956A1

SG187956A1 SG2013013990A SG2013013990A SG187956A1 SG 187956 A1 SG187956 A1 SG 187956A1 SG 2013013990 A SG2013013990 A SG 2013013990A SG 2013013990 A SG2013013990 A SG 2013013990A SG 187956 A1 SG187956 A1 SG 187956A1

Authority

SG

Singapore

Prior art keywords

phenyl

furo

pyridin

trimethoxy

methyl

Prior art date

2010-08-27

Links

• Espacenet
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• YRTCKZIKGWZNCU-UHFFFAOYSA-N furo[3,2-b]pyridine Chemical class C1=CC=C2OC=CC2=N1 YRTCKZIKGWZNCU-UHFFFAOYSA-N 0.000 title claims description 12
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• 230000009885 systemic effect Effects 0.000 claims abstract description 5
• 238000000034 method Methods 0.000 claims description 767
• -1 phenoxy, benzyloxy Chemical group 0.000 claims description 343
• 201000006417 multiple sclerosis Diseases 0.000 claims description 126
• 239000000203 mixture Substances 0.000 claims description 88
• 150000003839 salts Chemical class 0.000 claims description 78
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 43
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 42
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 40
• 239000012453 solvate Substances 0.000 claims description 39
• 125000004432 carbon atom Chemical group C* 0.000 claims description 37
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 32
• 239000002253 acid Substances 0.000 claims description 25
• 239000004480 active ingredient Substances 0.000 claims description 24
• 239000003814 drug Substances 0.000 claims description 23
• 125000004076 pyridyl group Chemical group 0.000 claims description 23
• 125000001544 thienyl group Chemical group 0.000 claims description 23
• 125000001425 triazolyl group Chemical group 0.000 claims description 23
• 125000002883 imidazolyl group Chemical group 0.000 claims description 22
• 125000001786 isothiazolyl group Chemical group 0.000 claims description 22
• 125000000842 isoxazolyl group Chemical group 0.000 claims description 22
• 125000002971 oxazolyl group Chemical group 0.000 claims description 22
• 125000003373 pyrazinyl group Chemical group 0.000 claims description 22
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 22
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 22
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 22
• 125000000335 thiazolyl group Chemical group 0.000 claims description 22
• 125000002541 furyl group Chemical group 0.000 claims description 21
• 125000003831 tetrazolyl group Chemical group 0.000 claims description 21
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 20
• 125000000217 alkyl group Chemical group 0.000 claims description 19
• 125000002098 pyridazinyl group Chemical group 0.000 claims description 19
• 125000001113 thiadiazolyl group Chemical group 0.000 claims description 19
• 125000001715 oxadiazolyl group Chemical group 0.000 claims description 18
• 229910052760 oxygen Inorganic materials 0.000 claims description 17
• 239000004305 biphenyl Substances 0.000 claims description 16
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• 125000001624 naphthyl group Chemical group 0.000 claims description 16
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• 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 12
• 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims description 12
• 125000001041 indolyl group Chemical group 0.000 claims description 12
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• 125000005493 quinolyl group Chemical group 0.000 claims description 12
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• 125000005874 benzothiadiazolyl group Chemical group 0.000 claims description 11
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• ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims description 10
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
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• OZSWAEYPIVJXRX-UHFFFAOYSA-N 2,3-dihydropyrazolyl Chemical group [N]1C=C=C=N1 OZSWAEYPIVJXRX-UHFFFAOYSA-N 0.000 claims description 6
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• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 5
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• WPJGHIVGAOVUAT-UHFFFAOYSA-N 1-(4-fluorophenyl)-2-oxopyridine-3-carboxylic acid Chemical compound O=C1C(C(=O)O)=CC=CN1C1=CC=C(F)C=C1 WPJGHIVGAOVUAT-UHFFFAOYSA-N 0.000 claims description 4
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 4
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