MX2012008509A - Agente terapeutico o profilactic para enfermedades del tracto biliar. - Google Patents

Agente terapeutico o profilactic para enfermedades del tracto biliar.

Info

Publication number
MX2012008509A
MX2012008509A MX2012008509A MX2012008509A MX2012008509A MX 2012008509 A MX2012008509 A MX 2012008509A MX 2012008509 A MX2012008509 A MX 2012008509A MX 2012008509 A MX2012008509 A MX 2012008509A MX 2012008509 A MX2012008509 A MX 2012008509A
Authority
MX
Mexico
Prior art keywords
biliary diseases
therapeutic
prophylactic agent
biliary
diseases
Prior art date
Application number
MX2012008509A
Other languages
English (en)
Other versions
MX362830B (es
Inventor
Ryosuke Kobayashi
Kaoru Nakao
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of MX2012008509A publication Critical patent/MX2012008509A/es
Publication of MX362830B publication Critical patent/MX362830B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Abstract

La presente invención apunta a proporcionar un fármaco novedoso el cual tiene un efecto terapéutico excelente sobre enfermedades del tracto biliar y es útil para terapia y/o profilaxis de enfermedades del tracto biliar. Mas particularmente, la presente invención proporciona un agente terapéutico o profiláctico para enfermedades del tracto biliar, el cual agente comprende como un componente efectivo un compuesto específico teniendo un esqueleto de morfinano representado por el Compuesto 1, o una sal de adición de ácido farmacéuticamente aceptable del mismo (Ver Formula).
MX2012008509A 2010-01-29 2011-01-28 Agente terapeutico o profilactico para enfermedades del tracto biliar. MX362830B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010018730 2010-01-29
PCT/JP2011/051737 WO2011093441A1 (ja) 2010-01-29 2011-01-28 胆道疾患の治療又は予防剤

Publications (2)

Publication Number Publication Date
MX2012008509A true MX2012008509A (es) 2012-08-31
MX362830B MX362830B (es) 2019-02-14

Family

ID=44319422

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012008509A MX362830B (es) 2010-01-29 2011-01-28 Agente terapeutico o profilactico para enfermedades del tracto biliar.

Country Status (15)

Country Link
US (1) US10131672B2 (es)
EP (1) EP2529739B1 (es)
JP (1) JP5867081B2 (es)
KR (1) KR101732042B1 (es)
CN (1) CN102711759B (es)
AU (1) AU2011211223B2 (es)
BR (1) BR112012018765B1 (es)
CA (1) CA2787323C (es)
ES (1) ES2582628T3 (es)
MX (1) MX362830B (es)
MY (1) MY173491A (es)
PL (1) PL2529739T3 (es)
RU (1) RU2554857C2 (es)
TW (1) TWI477505B (es)
WO (1) WO2011093441A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2630150B1 (en) * 2010-10-19 2017-04-12 Memorial Sloan-Kettering Cancer Center 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain
CN103327977B (zh) 2011-01-31 2016-05-04 东丽株式会社 恶液质的治疗或预防剂
CA2983314A1 (en) 2015-04-30 2016-11-03 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
CN106110220B (zh) * 2016-08-22 2020-01-07 陕西盘龙药业集团股份有限公司 一种治疗胆道疾病的中成药的制备工艺
AU2019229892A1 (en) 2018-03-08 2020-09-03 University Of Kansas Treatment of demyelinating diseases
SG11202100580UA (en) 2018-07-23 2021-02-25 Trevi Therapeutics Inc Treatment of chronic cough, breathlessness and dyspnea
US11214577B2 (en) * 2019-03-29 2022-01-04 Humanwell Pharmaceutical US Morphinans useful for treating medical disorders
IL309232A (en) 2021-06-14 2024-02-01 Scorpion Therapeutics Inc History of urea which can be used to treat cancer

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946848A (en) * 1985-10-29 1990-08-07 Baker Cumins Dermatologicals, Inc. Method of treating pruritus with nalmefene and clonidine
EP0591275B1 (en) * 1991-06-24 1999-03-31 Zeneca Limited Use of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione in the treatment of tyrosinaemia and pharmaceutical compositions
ATE172201T1 (de) 1992-01-23 1998-10-15 Toray Industries Morphinan-derivate und medizinische verwendung
CA2143318A1 (en) 1993-06-30 1995-01-12 Hiroshi Nagase Antitussive agents
KR100341950B1 (ko) 1993-07-19 2002-11-29 도레이 가부시끼가이샤 뇌세포보호제
DE69507697T2 (de) * 1994-05-31 1999-06-10 Mallinckrodt Chemical Inc Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält
CA2244256C (en) 1996-11-25 2006-07-11 Toray Industries, Inc. Antipruritic
WO1999005146A1 (fr) 1997-07-25 1999-02-04 Toray Industries, Inc. Remedes contre l'hyponatremie
JP4359711B2 (ja) 1997-09-02 2009-11-04 東レ株式会社 薬物依存症治療薬
JP2000053572A (ja) * 1998-08-11 2000-02-22 Toray Ind Inc ＯＲＬ１（ｏｐｉｏｉｄ ｏｒｐｈａｎ）受容体拮抗薬
WO2001014383A1 (fr) 1999-08-24 2001-03-01 Toray Industries, Inc. Remedes contre les douleurs neuropathiques et modeles animaux de douleurs neuropathiques
JP2001163784A (ja) 1999-12-06 2001-06-19 Toray Ind Inc 角膜または結膜用止痒剤
EP1380306B1 (en) * 2001-03-30 2009-03-04 Toray Industries, Inc. Remedies for restless leg syndrome
WO2002089845A1 (en) 2001-05-08 2002-11-14 Toray Industries, Inc. Remedies for sepsis
US20030054030A1 (en) * 2001-09-13 2003-03-20 Gary Gordon Method and compositions for the treatment of pruritus
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
US6852713B2 (en) 2003-04-16 2005-02-08 Adolor Corporation Lactam derivatives and methods of their use
US6992193B2 (en) 2003-06-10 2006-01-31 Adolor Corporation Sulfonylamino phenylacetamide derivatives and methods of their use
US7034051B2 (en) 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
US7160902B2 (en) 2003-11-14 2007-01-09 Adolor Corporation Amide derivatives and methods of their use
AU2006221314B2 (en) 2005-03-10 2012-09-06 Toray Industries, Inc. Antipruritic agent for pruritus caused by multiple sclerosis
JP5251870B2 (ja) * 2007-04-24 2013-07-31 東レ株式会社 ジスキネジアの治療または予防剤
KR101492029B1 (ko) 2007-06-22 2015-02-10 도레이 카부시키가이샤 통합 실조증의 치료 또는 예방제
KR101173509B1 (ko) * 2007-10-05 2012-08-14 도레이 카부시키가이샤 모르피난 유도체 또는 그 약리학적으로 허용되는 산부가염을 유효 성분으로 하는 피부 성상 개선 치료약
CA2714331C (en) * 2008-02-14 2016-08-09 Alkermes, Inc. Selective opioid compounds
WO2009132313A2 (en) * 2008-04-25 2009-10-29 Progenics Pharmaceuticals, Inc. Morphinan derivatives of organic and inorganic acids

Also Published As

Publication number Publication date
PL2529739T3 (pl) 2016-12-30
CN102711759B (zh) 2015-05-13
EP2529739A4 (en) 2015-03-11
TWI477505B (zh) 2015-03-21
RU2012136826A (ru) 2014-03-10
KR101732042B1 (ko) 2017-05-02
AU2011211223A1 (en) 2012-09-20
WO2011093441A1 (ja) 2011-08-04
ES2582628T3 (es) 2016-09-14
US20130203797A1 (en) 2013-08-08
BR112012018765B1 (pt) 2019-09-03
EP2529739B1 (en) 2016-07-13
JPWO2011093441A1 (ja) 2013-06-06
MY173491A (en) 2020-01-29
EP2529739A1 (en) 2012-12-05
BR112012018765A2 (pt) 2016-05-03
TW201200521A (en) 2012-01-01
KR20120139713A (ko) 2012-12-27
AU2011211223B2 (en) 2014-10-23
JP5867081B2 (ja) 2016-02-24
CN102711759A (zh) 2012-10-03
US10131672B2 (en) 2018-11-20
CA2787323C (en) 2017-08-29
RU2554857C2 (ru) 2015-06-27
MX362830B (es) 2019-02-14
CA2787323A1 (en) 2011-08-04

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