MX2012007678A - ß-CARBOLINAS PARA TRATAMIENTO DE DAÑOS A LA AUDICION Y VERTIGO. - Google Patents
ß-CARBOLINAS PARA TRATAMIENTO DE DAÑOS A LA AUDICION Y VERTIGO.Info
- Publication number
- MX2012007678A MX2012007678A MX2012007678A MX2012007678A MX2012007678A MX 2012007678 A MX2012007678 A MX 2012007678A MX 2012007678 A MX2012007678 A MX 2012007678A MX 2012007678 A MX2012007678 A MX 2012007678A MX 2012007678 A MX2012007678 A MX 2012007678A
- Authority
- MX
- Mexico
- Prior art keywords
- carboline
- cyclo
- methyl
- och3
- carbolines
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009060811 | 2009-12-28 | ||
| US28239510P | 2010-02-02 | 2010-02-02 | |
| PCT/DE2010/001530 WO2011079841A1 (de) | 2009-12-28 | 2010-12-28 | Beta-carboline zur behandlung von hörschäden und schwindel |
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| MX2012007678A true MX2012007678A (es) | 2012-09-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| MX2012007678A MX2012007678A (es) | 2009-12-28 | 2010-12-28 | ß-CARBOLINAS PARA TRATAMIENTO DE DAÑOS A LA AUDICION Y VERTIGO. |
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| EP (1) | EP2519238B1 (enExample) |
| JP (1) | JP5627705B2 (enExample) |
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| CN (1) | CN102844029A (enExample) |
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| BR (1) | BR112012015967B1 (enExample) |
| CA (1) | CA2785233C (enExample) |
| DE (1) | DE112010005017A5 (enExample) |
| IL (1) | IL220661A (enExample) |
| IN (1) | IN2012DN05066A (enExample) |
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| WO (1) | WO2011079841A1 (enExample) |
| ZA (1) | ZA201204476B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2968284T (pt) * | 2013-03-14 | 2021-06-28 | Osteoqc Inc | Derivados alquilamina de harmina para promoção de crescimento ósseo |
| PL2970890T3 (pl) | 2013-03-14 | 2020-11-16 | The Brigham And Women's Hospital, Inc. | Kompozycje i sposoby ekspansji i hodowli nabłonkowych komórek macierzystych |
| EP2853533A1 (de) | 2013-09-29 | 2015-04-01 | Audiocure Pharma GmbH | 6-Fluor-9-methyl-ß-carbolin |
| EP3189134A1 (en) | 2014-09-03 | 2017-07-12 | The Brigham and Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
| US11021687B2 (en) | 2016-01-08 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| EP3321264A1 (en) * | 2016-11-14 | 2018-05-16 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Selective inhibitors of genotoxic stress-induced ikk/nf-kb pathways |
| EP3562827A1 (en) | 2016-12-30 | 2019-11-06 | Frequency Therapeutics, Inc. | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
| AU2019320773B2 (en) | 2018-08-14 | 2024-12-05 | Ossifi Therapeutics Llc | Fluoro β-carboline compounds |
| US10947236B2 (en) | 2018-08-14 | 2021-03-16 | Osteoqc Inc. | Pyrrolo-dipyridine compounds |
| JP2021533788A (ja) | 2018-08-17 | 2021-12-09 | フリークエンシー セラピューティクス インコーポレイテッド | Ｊａｇ−１を上方制御することにより有毛細胞を生成するための組成物及び方法 |
| US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
| US12121501B2 (en) | 2018-09-12 | 2024-10-22 | Hough Ear Institute | Methods for treating hearing loss incident to cochlear implant surgery |
| EP3772515A1 (en) | 2019-08-09 | 2021-02-10 | Audiocure Pharma GmbH | Stable polymorphic form of 6-fluoro-9-methyl-9h-ss-carboline and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3240514A1 (de) | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| CA2140722A1 (en) | 1994-01-24 | 1995-07-25 | Joseph A. Jakubowski | Beta-carboline thromboxane synthase inhibitors |
| US20040038970A1 (en) | 1998-06-12 | 2004-02-26 | Societe De Conseils De Recherches Etd' Application Scientifiques, S.A.S. A Paris, France Corp. | Beta-carboline compounds |
| HUP0302962A2 (hu) * | 1998-06-12 | 2003-12-29 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása |
| US20050137220A1 (en) * | 2003-07-23 | 2005-06-23 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
| DE102007009264A1 (de) * | 2007-02-26 | 2008-08-28 | Ellneuroxx Ltd. | 9-Alkyl-ß-Carboline zur Behandlung von neurodegenerativen Erkrankungen |
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- 2010-12-28 EP EP10812791.1A patent/EP2519238B1/de active Active
- 2010-12-28 NZ NZ600478A patent/NZ600478A/xx unknown
- 2010-12-28 CA CA2785233A patent/CA2785233C/en active Active
- 2010-12-28 BR BR112012015967A patent/BR112012015967B1/pt active IP Right Grant
- 2010-12-28 WO PCT/DE2010/001530 patent/WO2011079841A1/de not_active Ceased
- 2010-12-28 AU AU2010338669A patent/AU2010338669A1/en not_active Abandoned
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- 2010-12-28 KR KR1020127017073A patent/KR20120098855A/ko not_active Withdrawn
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Also Published As
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| BR112012015967B1 (pt) | 2019-08-27 |
| US9107914B2 (en) | 2015-08-18 |
| CA2785233A1 (en) | 2011-06-07 |
| BR112012015967A2 (pt) | 2016-04-19 |
| NZ600478A (en) | 2013-10-25 |
| EP2519238A1 (de) | 2012-11-07 |
| EP2519238B1 (de) | 2014-08-13 |
| IL220661A (en) | 2016-03-31 |
| DE112010005017A5 (de) | 2012-10-04 |
| WO2011079841A1 (de) | 2011-07-07 |
| RU2012132429A (ru) | 2014-02-10 |
| US20130028958A1 (en) | 2013-01-31 |
| CN102844029A (zh) | 2012-12-26 |
| AU2010338669A1 (en) | 2012-06-21 |
| IL220661A0 (en) | 2012-08-30 |
| SG181599A1 (en) | 2012-07-30 |
| IN2012DN05066A (enExample) | 2015-10-09 |
| JP2013515752A (ja) | 2013-05-09 |
| ZA201204476B (en) | 2014-01-29 |
| CA2785233C (en) | 2018-10-09 |
| JP5627705B2 (ja) | 2014-11-19 |
| KR20120098855A (ko) | 2012-09-05 |
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