IL220661A - Preparations containing beta-carboline compounds and their use in the treatment of vertigo hearing loss - Google Patents
Preparations containing beta-carboline compounds and their use in the treatment of vertigo hearing lossInfo
- Publication number
- IL220661A IL220661A IL220661A IL22066112A IL220661A IL 220661 A IL220661 A IL 220661A IL 220661 A IL220661 A IL 220661A IL 22066112 A IL22066112 A IL 22066112A IL 220661 A IL220661 A IL 220661A
- Authority
- IL
- Israel
- Prior art keywords
- carbolines
- vertigo
- beta
- treatment
- hearing loss
- Prior art date
Links
- 206010011878 Deafness Diseases 0.000 title 1
- 208000012886 Vertigo Diseases 0.000 title 1
- 231100000888 hearing loss Toxicity 0.000 title 1
- 230000010370 hearing loss Effects 0.000 title 1
- 208000016354 hearing loss disease Diseases 0.000 title 1
- 231100000889 vertigo Toxicity 0.000 title 1
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009060811 | 2009-12-28 | ||
| US28239510P | 2010-02-02 | 2010-02-02 | |
| PCT/DE2010/001530 WO2011079841A1 (de) | 2009-12-28 | 2010-12-28 | Beta-carboline zur behandlung von hörschäden und schwindel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL220661A0 IL220661A0 (en) | 2012-08-30 |
| IL220661A true IL220661A (en) | 2016-03-31 |
Family
ID=44246908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL220661A IL220661A (en) | 2009-12-28 | 2012-06-26 | Preparations containing beta-carboline compounds and their use in the treatment of vertigo hearing loss |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9107914B2 (enExample) |
| EP (1) | EP2519238B1 (enExample) |
| JP (1) | JP5627705B2 (enExample) |
| KR (1) | KR20120098855A (enExample) |
| CN (1) | CN102844029A (enExample) |
| AU (1) | AU2010338669A1 (enExample) |
| BR (1) | BR112012015967B1 (enExample) |
| CA (1) | CA2785233C (enExample) |
| DE (1) | DE112010005017A5 (enExample) |
| IL (1) | IL220661A (enExample) |
| IN (1) | IN2012DN05066A (enExample) |
| MX (1) | MX2012007678A (enExample) |
| NZ (1) | NZ600478A (enExample) |
| RU (1) | RU2012132429A (enExample) |
| SG (1) | SG181599A1 (enExample) |
| WO (1) | WO2011079841A1 (enExample) |
| ZA (1) | ZA201204476B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2970890T3 (da) | 2013-03-14 | 2020-05-04 | Brigham & Womens Hospital Inc | Sammensætninger og fremgangsmåder til opformering og dyrkning af epitelstamceller |
| CN113416187B (zh) | 2013-03-14 | 2024-07-19 | 奥斯菲治疗有限公司 | 促进骨生长的烷基胺骆驼蓬碱衍生物 |
| EP2853533A1 (de) | 2013-09-29 | 2015-04-01 | Audiocure Pharma GmbH | 6-Fluor-9-methyl-ß-carbolin |
| WO2016037016A1 (en) | 2014-09-03 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
| JP2019506153A (ja) | 2016-01-08 | 2019-03-07 | マサチューセッツ インスティテュート オブ テクノロジー | 分化した腸内分泌細胞およびインスリン産生細胞の作製 |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| EP3321264A1 (en) * | 2016-11-14 | 2018-05-16 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Selective inhibitors of genotoxic stress-induced ikk/nf-kb pathways |
| MX390321B (es) | 2016-12-30 | 2025-03-20 | Frequency Therapeutics Inc | Compuestos de 1h-pirrol-2,5-diona y metodos de uso de los mismos para inducir la auto-renovacion de celulas madre/progenitoras de soporte. |
| ES3004565T3 (en) | 2018-08-14 | 2025-03-12 | Ossifi Therapeutics Llc | Pyrrolo - dipyridine compounds for the treatment of bone loss |
| JP7695496B2 (ja) | 2018-08-14 | 2025-06-19 | オシフィ セラピューティクス リミティド ライアビリティ カンパニー | フルオロβ－カルボリン化合物 |
| JP2021533788A (ja) | 2018-08-17 | 2021-12-09 | フリークエンシー セラピューティクス インコーポレイテッド | Ｊａｇ−１を上方制御することにより有毛細胞を生成するための組成物及び方法 |
| WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
| KR102899320B1 (ko) | 2018-09-12 | 2025-12-12 | 호 이어 인스티튜트 | 인공 와우 수술에 따른 난청의 치료 방법 |
| EP3772515A1 (en) * | 2019-08-09 | 2021-02-10 | Audiocure Pharma GmbH | Stable polymorphic form of 6-fluoro-9-methyl-9h-ss-carboline and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3240514A1 (de) | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| CA2140722A1 (en) | 1994-01-24 | 1995-07-25 | Joseph A. Jakubowski | Beta-carboline thromboxane synthase inhibitors |
| ES2188184T3 (es) * | 1998-06-12 | 2003-06-16 | Sod Conseils Rech Applic | Compuestos de beta-carbolinas. |
| US20040038970A1 (en) * | 1998-06-12 | 2004-02-26 | Societe De Conseils De Recherches Etd' Application Scientifiques, S.A.S. A Paris, France Corp. | Beta-carboline compounds |
| US20050137220A1 (en) * | 2003-07-23 | 2005-06-23 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
| DE102007009264A1 (de) | 2007-02-26 | 2008-08-28 | Ellneuroxx Ltd. | 9-Alkyl-ß-Carboline zur Behandlung von neurodegenerativen Erkrankungen |
-
2010
- 2010-12-28 BR BR112012015967A patent/BR112012015967B1/pt active IP Right Grant
- 2010-12-28 MX MX2012007678A patent/MX2012007678A/es not_active Application Discontinuation
- 2010-12-28 DE DE112010005017T patent/DE112010005017A5/de not_active Withdrawn
- 2010-12-28 EP EP10812791.1A patent/EP2519238B1/de active Active
- 2010-12-28 AU AU2010338669A patent/AU2010338669A1/en not_active Abandoned
- 2010-12-28 WO PCT/DE2010/001530 patent/WO2011079841A1/de not_active Ceased
- 2010-12-28 CN CN2010800630256A patent/CN102844029A/zh active Pending
- 2010-12-28 KR KR1020127017073A patent/KR20120098855A/ko not_active Withdrawn
- 2010-12-28 JP JP2012546361A patent/JP5627705B2/ja active Active
- 2010-12-28 NZ NZ600478A patent/NZ600478A/xx unknown
- 2010-12-28 RU RU2012132429/04A patent/RU2012132429A/ru not_active Application Discontinuation
- 2010-12-28 US US13/514,171 patent/US9107914B2/en active Active
- 2010-12-28 SG SG2012042438A patent/SG181599A1/en unknown
- 2010-12-28 CA CA2785233A patent/CA2785233C/en active Active
-
2012
- 2012-06-07 IN IN5066DEN2012 patent/IN2012DN05066A/en unknown
- 2012-06-18 ZA ZA2012/04476A patent/ZA201204476B/en unknown
- 2012-06-26 IL IL220661A patent/IL220661A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US9107914B2 (en) | 2015-08-18 |
| NZ600478A (en) | 2013-10-25 |
| MX2012007678A (es) | 2012-09-12 |
| CA2785233A1 (en) | 2011-06-07 |
| EP2519238A1 (de) | 2012-11-07 |
| JP5627705B2 (ja) | 2014-11-19 |
| EP2519238B1 (de) | 2014-08-13 |
| IN2012DN05066A (enExample) | 2015-10-09 |
| CN102844029A (zh) | 2012-12-26 |
| RU2012132429A (ru) | 2014-02-10 |
| CA2785233C (en) | 2018-10-09 |
| BR112012015967A2 (pt) | 2016-04-19 |
| IL220661A0 (en) | 2012-08-30 |
| AU2010338669A1 (en) | 2012-06-21 |
| BR112012015967B1 (pt) | 2019-08-27 |
| US20130028958A1 (en) | 2013-01-31 |
| SG181599A1 (en) | 2012-07-30 |
| JP2013515752A (ja) | 2013-05-09 |
| DE112010005017A5 (de) | 2012-10-04 |
| WO2011079841A1 (de) | 2011-07-07 |
| KR20120098855A (ko) | 2012-09-05 |
| ZA201204476B (en) | 2014-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |