CN102844029A - 用于治疗听力损伤和眩晕的β-咔啉 - Google Patents

用于治疗听力损伤和眩晕的β-咔啉 Download PDF

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Publication number
CN102844029A
CN102844029A CN2010800630256A CN201080063025A CN102844029A CN 102844029 A CN102844029 A CN 102844029A CN 2010800630256 A CN2010800630256 A CN 2010800630256A CN 201080063025 A CN201080063025 A CN 201080063025A CN 102844029 A CN102844029 A CN 102844029A
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CN
China
Prior art keywords
cyclo
carboline
och
beta
methyl
Prior art date
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Pending
Application number
CN2010800630256A
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English (en)
Chinese (zh)
Inventor
H·罗美尔斯巴奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AUDIOCURE PHARMA GmbH
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AUDIOCURE PHARMA GmbH
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Filing date
Publication date
Application filed by AUDIOCURE PHARMA GmbH filed Critical AUDIOCURE PHARMA GmbH
Publication of CN102844029A publication Critical patent/CN102844029A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2010800630256A 2009-12-28 2010-12-28 用于治疗听力损伤和眩晕的β-咔啉 Pending CN102844029A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE102009060811 2009-12-28
DE102009060811.7 2009-12-28
US28239510P 2010-02-02 2010-02-02
US61/282,395 2010-02-02
PCT/DE2010/001530 WO2011079841A1 (de) 2009-12-28 2010-12-28 Beta-carboline zur behandlung von hörschäden und schwindel

Publications (1)

Publication Number Publication Date
CN102844029A true CN102844029A (zh) 2012-12-26

Family

ID=44246908

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800630256A Pending CN102844029A (zh) 2009-12-28 2010-12-28 用于治疗听力损伤和眩晕的β-咔啉

Country Status (17)

Country Link
US (1) US9107914B2 (enExample)
EP (1) EP2519238B1 (enExample)
JP (1) JP5627705B2 (enExample)
KR (1) KR20120098855A (enExample)
CN (1) CN102844029A (enExample)
AU (1) AU2010338669A1 (enExample)
BR (1) BR112012015967B1 (enExample)
CA (1) CA2785233C (enExample)
DE (1) DE112010005017A5 (enExample)
IL (1) IL220661A (enExample)
IN (1) IN2012DN05066A (enExample)
MX (1) MX2012007678A (enExample)
NZ (1) NZ600478A (enExample)
RU (1) RU2012132429A (enExample)
SG (1) SG181599A1 (enExample)
WO (1) WO2011079841A1 (enExample)
ZA (1) ZA201204476B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105579455A (zh) * 2013-09-29 2016-05-11 音频治疗制药有限公司 氟-9-甲基-β-咔啉
CN109963850A (zh) * 2016-11-14 2019-07-02 马克思-德布鲁克-分子医学中心亥姆霍兹联合会 基因毒性应激诱导性IKK/NF-κB途径的选择性抑制剂

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3184040A1 (en) 2013-03-14 2014-10-02 The Brigham And Women's Hospital, Inc. Compositions and methods for epithelial stem cell expansion comprising a wnt agonist and a histone deacetylase inhibitor
DK2968284T3 (da) 2013-03-14 2021-06-14 Osteoqc Inc Alkyl-amin-harminderivater til fremme af knoglevækst
WO2016037016A1 (en) 2014-09-03 2016-03-10 The Brigham And Women's Hospital, Inc. Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
AU2017205194A1 (en) 2016-01-08 2018-07-19 Massachusetts Institute Of Technology Production of differentiated enteroendocrine cells and insulin producing cells
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
CN110392686A (zh) 2016-12-30 2019-10-29 频率治疗公司 1h-吡咯-2,5-二酮化合物以及使用它们来诱导干/祖支持细胞自我更新的方法
CN112996506A (zh) 2018-08-14 2021-06-18 奥斯特克有限公司 吡咯并二吡啶化合物
BR112021002655A2 (pt) 2018-08-14 2021-05-04 Osteoqc Inc. compostos flúor ss-carbolina
WO2020037326A1 (en) 2018-08-17 2020-02-20 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating foxo
US11162071B2 (en) 2018-08-17 2021-11-02 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating JAG-1
EP3849530A4 (en) * 2018-09-12 2022-06-22 Hough Ear Institute Methods for treating hearing loss incident to cochlear implant surgery
EP3772515A1 (en) * 2019-08-09 2021-02-10 Audiocure Pharma GmbH Stable polymorphic form of 6-fluoro-9-methyl-9h-ss-carboline and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1308632A (zh) * 1998-06-12 2001-08-15 研究及应用科学协会股份有限公司 β－咔啉化合物
WO2008104161A1 (de) * 2007-02-26 2008-09-04 Ellneuroxx Ltd. ß-CARBOLINE ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3240514A1 (de) 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
CA2140722A1 (en) 1994-01-24 1995-07-25 Joseph A. Jakubowski Beta-carboline thromboxane synthase inhibitors
US20040038970A1 (en) 1998-06-12 2004-02-26 Societe De Conseils De Recherches Etd' Application Scientifiques, S.A.S. A Paris, France Corp. Beta-carboline compounds
US20050143371A1 (en) * 2003-07-23 2005-06-30 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1308632A (zh) * 1998-06-12 2001-08-15 研究及应用科学协会股份有限公司 β－咔啉化合物
WO2008104161A1 (de) * 2007-02-26 2008-09-04 Ellneuroxx Ltd. ß-CARBOLINE ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIANG XING QUN，ET AL: "Neurotrophic Factors in the Auditory Periphery", 《ANNALS OF THE NEW YORK ACADEMY OF SCIENCES》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105579455A (zh) * 2013-09-29 2016-05-11 音频治疗制药有限公司 氟-9-甲基-β-咔啉
CN105579455B (zh) * 2013-09-29 2017-07-28 音频治疗制药有限公司 氟‑9‑甲基‑β‑咔啉
CN109963850A (zh) * 2016-11-14 2019-07-02 马克思-德布鲁克-分子医学中心亥姆霍兹联合会 基因毒性应激诱导性IKK/NF-κB途径的选择性抑制剂

Also Published As

Publication number Publication date
EP2519238A1 (de) 2012-11-07
KR20120098855A (ko) 2012-09-05
CA2785233A1 (en) 2011-06-07
CA2785233C (en) 2018-10-09
ZA201204476B (en) 2014-01-29
MX2012007678A (es) 2012-09-12
SG181599A1 (en) 2012-07-30
BR112012015967A2 (pt) 2016-04-19
NZ600478A (en) 2013-10-25
EP2519238B1 (de) 2014-08-13
US20130028958A1 (en) 2013-01-31
BR112012015967B1 (pt) 2019-08-27
IN2012DN05066A (enExample) 2015-10-09
JP5627705B2 (ja) 2014-11-19
RU2012132429A (ru) 2014-02-10
WO2011079841A1 (de) 2011-07-07
AU2010338669A1 (en) 2012-06-21
IL220661A0 (en) 2012-08-30
JP2013515752A (ja) 2013-05-09
IL220661A (en) 2016-03-31
DE112010005017A5 (de) 2012-10-04
US9107914B2 (en) 2015-08-18

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Application publication date: 20121226