MX2012003603A - Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihid ropiridina fluoro-sustituidos y procedimientos de uso de los mismos. - Google Patents
Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihid ropiridina fluoro-sustituidos y procedimientos de uso de los mismos.Info
- Publication number
- MX2012003603A MX2012003603A MX2012003603A MX2012003603A MX2012003603A MX 2012003603 A MX2012003603 A MX 2012003603A MX 2012003603 A MX2012003603 A MX 2012003603A MX 2012003603 A MX2012003603 A MX 2012003603A MX 2012003603 A MX2012003603 A MX 2012003603A
- Authority
- MX
- Mexico
- Prior art keywords
- indazol
- dicyano
- substituted
- fluoro
- methods
- Prior art date
Links
- -1 Fluoro-substituted 3,5-dicyano-4-(1h-indazol-5-yl)-2,6-dim ethyl-1,4-dihydropyridine Chemical class 0.000 title abstract 2
- 229940085304 dihydropyridine derivative selective calcium channel blockers with mainly vascular effects Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172304 | 2009-10-06 | ||
| PCT/EP2010/064648 WO2011042368A1 (en) | 2009-10-06 | 2010-10-01 | Fluoro-substituted 3,5-dicyano-4-(1h-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012003603A true MX2012003603A (es) | 2012-04-20 |
Family
ID=43357944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012003603A MX2012003603A (es) | 2009-10-06 | 2010-10-01 | Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihid ropiridina fluoro-sustituidos y procedimientos de uso de los mismos. |
Country Status (27)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0650179Y2 (ja) | 1989-06-01 | 1994-12-21 | 株式会社プラコー | ブロー成形機用のダイヘッド |
| JPH0756186Y2 (ja) | 1989-07-24 | 1995-12-25 | 株式会社日本製鋼所 | パリソンの押出成形装置 |
| JP2781376B2 (ja) | 1996-06-17 | 1998-07-30 | エクセル株式会社 | 中空成形品 |
| DE102009056886A1 (de) * | 2009-12-03 | 2011-06-09 | Bayer Schering Pharma Aktiengesellschaft | cMet-Inhibitoren zur Behandlung der Endometriose |
| SI3924340T1 (sl) | 2019-02-11 | 2025-04-30 | Merck Patent Gmbh | Derivati indazolil-izoksazola za zdravljenje bolezni, kot je na primer rak |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3635977A (en) | 1969-11-03 | 1972-01-18 | American Cyanamid Co | Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil |
| EP0379917B1 (de) | 1989-01-26 | 1995-08-09 | Bayer Ag | Optisch aktive (Meth)Acrylsäure-Derivate, ihre Herstellung, ihre Polymerisation zu optisch aktiven Polymeren und deren Verwendung |
| DE19546136A1 (de) | 1995-12-11 | 1997-06-12 | Bayer Ag | Chirale stationäre Phasen für die chromatographische Trennung von optischen Isomeren |
| KR20050004214A (ko) | 2002-05-31 | 2005-01-12 | 에자이 가부시키가이샤 | 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물 |
| JP2007526324A (ja) | 2004-03-02 | 2007-09-13 | スミスクライン・ビーチャム・コーポレイション | Ａｋｔ活性のある阻害剤 |
| WO2005084672A1 (de) | 2004-03-03 | 2005-09-15 | Boehringer Ingelheim International Gmbh | Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| JP2008523108A (ja) | 2004-12-13 | 2008-07-03 | アイアールエム・リミテッド・ライアビリティ・カンパニー | ステロイドホルモン核内受容体およびカルシウムチャネル活性のモジュレーターとしての化合物および組成物 |
| CA2603676A1 (en) | 2005-01-07 | 2006-07-13 | Roskamp Research Llc | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds |
| EP1855664A4 (en) * | 2005-01-19 | 2009-12-23 | Merck & Co Inc | INHIBITORS OF MITOTIC KINESINE |
| EP2121608B1 (en) | 2006-12-14 | 2012-11-14 | Bayer Intellectual Property GmbH | Dihydropyridine derivatives useful as protein kinase inhibitors |
-
2010
- 2010-09-30 UY UY0001032922A patent/UY32922A/es not_active Application Discontinuation
- 2010-10-01 SG SG2012015400A patent/SG178990A1/en unknown
- 2010-10-01 CN CN201080043306.5A patent/CN102573838B/zh not_active Expired - Fee Related
- 2010-10-01 RU RU2012111695/04A patent/RU2012111695A/ru not_active Application Discontinuation
- 2010-10-01 US US13/496,722 patent/US9422263B2/en not_active Expired - Fee Related
- 2010-10-01 ES ES10760348.2T patent/ES2458117T3/es active Active
- 2010-10-01 WO PCT/EP2010/064648 patent/WO2011042368A1/en not_active Ceased
- 2010-10-01 JP JP2012532550A patent/JP5753175B2/ja not_active Expired - Fee Related
- 2010-10-01 AR ARP100103574A patent/AR078486A1/es unknown
- 2010-10-01 KR KR1020127007824A patent/KR20120091005A/ko not_active Withdrawn
- 2010-10-01 PH PH1/2012/500640A patent/PH12012500640A1/en unknown
- 2010-10-01 NZ NZ599006A patent/NZ599006A/xx not_active IP Right Cessation
- 2010-10-01 CA CA2773676A patent/CA2773676C/en not_active Expired - Fee Related
- 2010-10-01 IN IN2675DEN2012 patent/IN2012DN02675A/en unknown
- 2010-10-01 PE PE2012000384A patent/PE20121392A1/es not_active Application Discontinuation
- 2010-10-01 EP EP10760348.2A patent/EP2485726B1/en not_active Not-in-force
- 2010-10-01 MX MX2012003603A patent/MX2012003603A/es not_active Application Discontinuation
- 2010-10-01 AU AU2010305550A patent/AU2010305550A1/en not_active Abandoned
- 2010-10-01 BR BR112012006842A patent/BR112012006842A2/pt not_active Application Discontinuation
- 2010-10-05 TW TW099133784A patent/TW201124396A/zh unknown
-
2012
- 2012-02-29 ZA ZA2012/01524A patent/ZA201201524B/en unknown
- 2012-03-01 IL IL218415A patent/IL218415A0/en unknown
- 2012-03-26 CU CU20120051A patent/CU20120051A7/es unknown
- 2012-03-26 CL CL2012000753A patent/CL2012000753A1/es unknown
- 2012-03-27 EC ECSP12011748 patent/ECSP12011748A/es unknown
- 2012-03-27 CR CR20120150A patent/CR20120150A/es unknown
- 2012-03-27 DO DO2012000085A patent/DOP2012000085A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1172835A1 (en) | 2013-05-03 |
| US20120264785A1 (en) | 2012-10-18 |
| SG178990A1 (en) | 2012-04-27 |
| KR20120091005A (ko) | 2012-08-17 |
| CU20120051A7 (es) | 2012-06-29 |
| PH12012500640A1 (en) | 2012-11-12 |
| JP2013506699A (ja) | 2013-02-28 |
| BR112012006842A2 (pt) | 2016-06-07 |
| UY32922A (es) | 2011-04-29 |
| TW201124396A (en) | 2011-07-16 |
| NZ599006A (en) | 2013-11-29 |
| EP2485726B1 (en) | 2014-03-12 |
| CR20120150A (es) | 2012-08-03 |
| CA2773676C (en) | 2017-07-04 |
| IN2012DN02675A (cg-RX-API-DMAC7.html) | 2015-09-04 |
| IL218415A0 (en) | 2012-04-30 |
| JP5753175B2 (ja) | 2015-07-22 |
| EP2485726A1 (en) | 2012-08-15 |
| ES2458117T3 (es) | 2014-04-30 |
| AU2010305550A1 (en) | 2012-03-29 |
| CA2773676A1 (en) | 2011-04-14 |
| CN102573838B (zh) | 2014-09-24 |
| WO2011042368A1 (en) | 2011-04-14 |
| CN102573838A (zh) | 2012-07-11 |
| ECSP12011748A (es) | 2012-05-30 |
| US9422263B2 (en) | 2016-08-23 |
| DOP2012000085A (es) | 2012-07-15 |
| CL2012000753A1 (es) | 2012-09-14 |
| AR078486A1 (es) | 2011-11-09 |
| RU2012111695A (ru) | 2013-10-10 |
| PE20121392A1 (es) | 2012-10-14 |
| ZA201201524B (en) | 2013-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: BAYER INTELLECTUAL PROPERTY GMBH |
|
| FA | Abandonment or withdrawal |