MX2012001469A - Reparacion regioselectiva de derivados de 2-amino-5-trifluorometil pirimidina. - Google Patents
Reparacion regioselectiva de derivados de 2-amino-5-trifluorometil pirimidina.Info
- Publication number
- MX2012001469A MX2012001469A MX2012001469A MX2012001469A MX2012001469A MX 2012001469 A MX2012001469 A MX 2012001469A MX 2012001469 A MX2012001469 A MX 2012001469A MX 2012001469 A MX2012001469 A MX 2012001469A MX 2012001469 A MX2012001469 A MX 2012001469A
- Authority
- MX
- Mexico
- Prior art keywords
- data
- group
- formula
- optionally substituted
- suitable substituents
- Prior art date
Links
- OUVVCECMELPNNT-UHFFFAOYSA-N 5-(trifluoromethyl)pyrimidin-2-amine Chemical compound NC1=NC=C(C(F)(F)F)C=N1 OUVVCECMELPNNT-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 8
- 125000001424 substituent group Chemical group 0.000 abstract 8
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000001412 amines Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- -1 phenyloxy Chemical group 0.000 abstract 2
- 150000003230 pyrimidines Chemical class 0.000 abstract 2
- 238000013475 authorization Methods 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09167934 | 2009-08-14 | ||
| PCT/EP2010/061840 WO2011018518A1 (en) | 2009-08-14 | 2010-08-13 | Regioselective preparation of 2 -amino-5-trifluoromethylpyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012001469A true MX2012001469A (es) | 2012-02-22 |
Family
ID=42712695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012001469A MX2012001469A (es) | 2009-08-14 | 2010-08-13 | Reparacion regioselectiva de derivados de 2-amino-5-trifluorometil pirimidina. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8933227B2 (enExample) |
| EP (1) | EP2464634B1 (enExample) |
| JP (1) | JP5539519B2 (enExample) |
| KR (1) | KR20120046248A (enExample) |
| CN (1) | CN102471287A (enExample) |
| AR (1) | AR077925A1 (enExample) |
| AU (1) | AU2010283713A1 (enExample) |
| BR (1) | BR112012002971A2 (enExample) |
| CA (1) | CA2767965A1 (enExample) |
| CL (1) | CL2012000278A1 (enExample) |
| EA (1) | EA201200282A1 (enExample) |
| IL (1) | IL217112A0 (enExample) |
| IN (1) | IN2012DN01342A (enExample) |
| MX (1) | MX2012001469A (enExample) |
| NZ (1) | NZ597538A (enExample) |
| TW (1) | TW201124385A (enExample) |
| WO (1) | WO2011018518A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2268621A1 (en) * | 2008-03-20 | 2011-01-05 | Boehringer Ingelheim International GmbH | Regioselective preparation of substituted pyrimidines |
| UY31714A (es) * | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| US8729265B2 (en) | 2009-08-14 | 2014-05-20 | Boehringer Ingelheim International Gmbh | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| CN102887860B (zh) * | 2012-09-29 | 2015-07-01 | 上海泰坦科技有限公司 | 4-氯-6-三氟甲基嘧啶类化合物的制备方法 |
| JP6391985B2 (ja) * | 2014-05-16 | 2018-09-19 | 東ソー・ファインケム株式会社 | ２−置換−４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
| JP6391988B2 (ja) * | 2014-05-21 | 2018-09-19 | 東ソー・ファインケム株式会社 | ５−（トリフルオロメチル）ピリミジン誘導体の製造方法及び新規５−（トリフルオロメチル）ピリミジン誘導体 |
| JP6262079B2 (ja) * | 2014-06-02 | 2018-01-17 | 東ソー・ファインケム株式会社 | ４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
| JP6431294B2 (ja) * | 2014-06-16 | 2018-11-28 | 東ソー・ファインケム株式会社 | ５−（トリフルオロメチル）ピリミジン誘導体及びその製造法 |
| JP6479486B2 (ja) * | 2015-01-16 | 2019-03-06 | 東ソー・ファインケム株式会社 | ４−アルコキシ−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
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| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| EP1438053B1 (de) | 2001-10-17 | 2008-09-10 | Boehringer Ingelheim Pharma GmbH & Co.KG | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
| DE10161763A1 (de) | 2001-12-15 | 2003-07-17 | Bayer Cropsience Ltd | Neues herbizides Verfahren |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| WO2003095448A1 (en) | 2002-05-06 | 2003-11-20 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
| TW200406374A (en) | 2002-05-29 | 2004-05-01 | Novartis Ag | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases |
| WO2004048343A1 (en) | 2002-11-28 | 2004-06-10 | Schering Aktiengesellschaft | Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
| ATE458731T1 (de) | 2002-12-20 | 2010-03-15 | Pfizer Prod Inc | Pyrimidin-derivate zur behandlung von anormalem zellwachstum |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| DE602004004287T2 (de) | 2003-09-05 | 2007-06-21 | Pfizer Products Inc., Groton | Selektive synthese von cf3-substituierten pyrimidinen |
| US20070105839A1 (en) | 2003-09-18 | 2007-05-10 | Patricia Imbach | 2, 4-Di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
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| EP1598343A1 (de) | 2004-05-19 | 2005-11-23 | Boehringer Ingelheim International GmbH | 2-Arylaminopyrimidine als PLK Inhibitoren |
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| UY31714A (es) | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
| EP2268621A1 (en) * | 2008-03-20 | 2011-01-05 | Boehringer Ingelheim International GmbH | Regioselective preparation of substituted pyrimidines |
| PE20100087A1 (es) | 2008-06-25 | 2010-02-08 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa |
| MX2010014568A (es) | 2008-06-25 | 2011-03-29 | Irm Llc | Derivados de pirmidina como inhibidores de cinasa. |
| TWI458721B (zh) | 2008-06-27 | 2014-11-01 | Celgene Avilomics Res Inc | 雜芳基化合物及其用途 |
| EP2179992A1 (de) | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Sulfonsubstituierte Anlinopyrimidinderivative als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| EP2179991A1 (de) | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| UY32240A (es) | 2008-11-14 | 2010-06-30 | Boeringer Ingelheim Kg | Nuevas 2,4-diaminopirimidinas, sus sales farmacéuticamente aceptables, composiciones conteniéndolas y aplicaciones. |
| TW201024281A (en) | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| AR074210A1 (es) | 2008-11-24 | 2010-12-29 | Boehringer Ingelheim Int | Derivados de pirimidina como inhibidores de ptk2-quinasa |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| US8729265B2 (en) * | 2009-08-14 | 2014-05-20 | Boehringer Ingelheim International Gmbh | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
-
2010
- 2010-08-10 US US12/853,732 patent/US8933227B2/en active Active
- 2010-08-13 WO PCT/EP2010/061840 patent/WO2011018518A1/en not_active Ceased
- 2010-08-13 CN CN2010800346368A patent/CN102471287A/zh active Pending
- 2010-08-13 IN IN1342DEN2012 patent/IN2012DN01342A/en unknown
- 2010-08-13 CA CA2767965A patent/CA2767965A1/en not_active Abandoned
- 2010-08-13 EP EP10744917.5A patent/EP2464634B1/en active Active
- 2010-08-13 KR KR1020127003436A patent/KR20120046248A/ko not_active Withdrawn
- 2010-08-13 MX MX2012001469A patent/MX2012001469A/es not_active Application Discontinuation
- 2010-08-13 BR BR112012002971A patent/BR112012002971A2/pt not_active IP Right Cessation
- 2010-08-13 EA EA201200282A patent/EA201200282A1/ru unknown
- 2010-08-13 TW TW099127176A patent/TW201124385A/zh unknown
- 2010-08-13 AR ARP100103001A patent/AR077925A1/es unknown
- 2010-08-13 NZ NZ597538A patent/NZ597538A/en not_active IP Right Cessation
- 2010-08-13 AU AU2010283713A patent/AU2010283713A1/en not_active Abandoned
- 2010-08-13 JP JP2012524242A patent/JP5539519B2/ja active Active
-
2011
- 2011-12-21 IL IL217112A patent/IL217112A0/en unknown
-
2012
- 2012-02-02 CL CL2012000278A patent/CL2012000278A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201124385A (en) | 2011-07-16 |
| EA201200282A1 (ru) | 2012-09-28 |
| JP5539519B2 (ja) | 2014-07-02 |
| EP2464634B1 (en) | 2016-11-30 |
| IN2012DN01342A (enExample) | 2015-06-05 |
| AU2010283713A1 (en) | 2012-02-02 |
| CA2767965A1 (en) | 2011-02-17 |
| KR20120046248A (ko) | 2012-05-09 |
| US8933227B2 (en) | 2015-01-13 |
| IL217112A0 (en) | 2012-02-29 |
| BR112012002971A2 (pt) | 2015-10-13 |
| JP2013501759A (ja) | 2013-01-17 |
| CN102471287A (zh) | 2012-05-23 |
| NZ597538A (en) | 2014-05-30 |
| AR077925A1 (es) | 2011-10-05 |
| WO2011018518A1 (en) | 2011-02-17 |
| EP2464634A1 (en) | 2012-06-20 |
| US20110190499A1 (en) | 2011-08-04 |
| CL2012000278A1 (es) | 2012-10-12 |
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