MX2012000572A - Moduladores del receptor 5-hidroxi triptamina 3 (5-ht3), metodos para su realización y uso de los mismos. - Google Patents

Moduladores del receptor 5-hidroxi triptamina 3 (5-ht3), metodos para su realización y uso de los mismos.

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Publication number
MX2012000572A
MX2012000572A MX2012000572A MX2012000572A MX2012000572A MX 2012000572 A MX2012000572 A MX 2012000572A MX 2012000572 A MX2012000572 A MX 2012000572A MX 2012000572 A MX2012000572 A MX 2012000572A MX 2012000572 A MX2012000572 A MX 2012000572A
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MX
Mexico
Prior art keywords
making
methods
receptor modulators
vomiting
compounds
Prior art date
Application number
MX2012000572A
Other languages
English (en)
Inventor
Peter R Guzzo
David D Manning
William Earley
Original Assignee
Albany Molecular Res Inc
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Publication date
Application filed by Albany Molecular Res Inc filed Critical Albany Molecular Res Inc
Publication of MX2012000572A publication Critical patent/MX2012000572A/es

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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Addiction (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a moduladores del receptor de 5-HT3 novedosos. Estos compuestos se usan en el tratamiento de varios trastornos incluyendo náuseas y vómitos inducidos por quimioterapia, náuseas y vómitos postoperatorios y síndrome del intestino irritable. Los métodos para realizar estos compuestos también se describen en la presente invención.
MX2012000572A 2009-07-14 2010-06-30 Moduladores del receptor 5-hidroxi triptamina 3 (5-ht3), metodos para su realización y uso de los mismos. MX2012000572A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22536809P 2009-07-14 2009-07-14
PCT/US2010/040617 WO2011008572A2 (en) 2009-07-14 2010-06-30 5-ht3 receptor modulators, methods of making, and use thereof

Publications (1)

Publication Number Publication Date
MX2012000572A true MX2012000572A (es) 2012-05-08

Family

ID=43450096

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000572A MX2012000572A (es) 2009-07-14 2010-06-30 Moduladores del receptor 5-hidroxi triptamina 3 (5-ht3), metodos para su realización y uso de los mismos.

Country Status (13)

Country Link
US (2) US8710046B2 (es)
EP (1) EP2459563A4 (es)
JP (1) JP5663572B2 (es)
KR (1) KR20120104512A (es)
CN (1) CN102510862A (es)
AU (1) AU2010273732A1 (es)
BR (1) BR112012000788A2 (es)
CA (1) CA2767233A1 (es)
IL (1) IL217297A0 (es)
MX (1) MX2012000572A (es)
NZ (1) NZ597613A (es)
SG (1) SG177523A1 (es)
WO (1) WO2011008572A2 (es)

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KR101653707B1 (ko) 2008-05-29 2016-09-02 알바니 몰레큘라 리써치, 인크. 5-ｈｔ3 수용체 조절제, 이의 제조 방법, 및 그의 용도
JP6433922B2 (ja) * 2013-02-27 2018-12-05 アレイ バイオファーマ、インコーポレイテッド インダゾール誘導体の調製に使用するための中間体およびその調製方法
WO2015113057A1 (en) 2014-01-27 2015-07-30 Allergan, Inc. Antagonists acting at multiple prostaglandin receptors for the treatment of inflammation
CN111825702A (zh) * 2019-04-22 2020-10-27 成都科岭源医药技术有限公司 一种氮杂*并吲唑类衍生物及其制备方法和用途
CN112390799B (zh) * 2019-08-16 2022-04-29 科岭源生物科技(深圳)有限公司 一种含氮杂环类5-ht3受体调节剂及其制备方法和用途

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CA2767233A1 (en) 2011-01-20
SG177523A1 (en) 2012-02-28
EP2459563A4 (en) 2013-01-16
WO2011008572A2 (en) 2011-01-20
US20120270857A1 (en) 2012-10-25
CN102510862A (zh) 2012-06-20
BR112012000788A2 (pt) 2016-02-23
JP2012533544A (ja) 2012-12-27
NZ597613A (en) 2014-01-31
US20140234443A1 (en) 2014-08-21
EP2459563A2 (en) 2012-06-06
KR20120104512A (ko) 2012-09-21
US9045501B2 (en) 2015-06-02
US8710046B2 (en) 2014-04-29
AU2010273732A1 (en) 2012-02-09
IL217297A0 (en) 2012-02-29
WO2011008572A3 (en) 2011-06-03
JP5663572B2 (ja) 2015-02-04

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