MX2011012522A - Inhibidores de pirazol sustituido de proteina cinasa c-met. - Google Patents
Inhibidores de pirazol sustituido de proteina cinasa c-met.Info
- Publication number
- MX2011012522A MX2011012522A MX2011012522A MX2011012522A MX2011012522A MX 2011012522 A MX2011012522 A MX 2011012522A MX 2011012522 A MX2011012522 A MX 2011012522A MX 2011012522 A MX2011012522 A MX 2011012522A MX 2011012522 A MX2011012522 A MX 2011012522A
- Authority
- MX
- Mexico
- Prior art keywords
- protein kinase
- met protein
- substituted pyrazole
- pyrazole inhibitors
- inhibitors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000008022 Proto-Oncogene Proteins c-met Human genes 0.000 abstract 1
- 108010089836 Proto-Oncogene Proteins c-met Proteins 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18178409P | 2009-05-28 | 2009-05-28 | |
| PCT/US2010/036309 WO2010138663A1 (en) | 2009-05-28 | 2010-05-27 | Substituted pyrazole inhibitors of c-met protein kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011012522A true MX2011012522A (es) | 2012-02-08 |
Family
ID=42370912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011012522A MX2011012522A (es) | 2009-05-28 | 2010-05-27 | Inhibidores de pirazol sustituido de proteina cinasa c-met. |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8269012B2 (OSRAM) |
| EP (1) | EP2435444A1 (OSRAM) |
| JP (1) | JP2012528185A (OSRAM) |
| CN (1) | CN102448968A (OSRAM) |
| AU (1) | AU2010254053A1 (OSRAM) |
| CA (1) | CA2762186A1 (OSRAM) |
| MX (1) | MX2011012522A (OSRAM) |
| WO (1) | WO2010138663A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2435443B1 (en) * | 2009-05-28 | 2013-07-31 | Vertex Pharmaceuticals Incorporated | Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase |
| KR102148355B1 (ko) * | 2012-07-27 | 2020-08-26 | 사토 파머슈티컬 가부시키가이샤 | 디플루오로메틸렌 화합물 |
| CN103073491A (zh) * | 2013-01-25 | 2013-05-01 | 桑迪亚医药技术（上海）有限责任公司 | 一种2-（5,7-二氟-6-喹啉基）乙酸/丙酸（酯）的合成方法 |
| CN106924260B (zh) * | 2015-12-31 | 2018-05-25 | 北京浦润奥生物科技有限责任公司 | 化合物在制备用于治疗脑胶质瘤的药物中的用途 |
| GR1009565B (el) | 2016-07-14 | 2019-08-06 | Galenica Α.Ε. | Νεα παραγωγα 1,2,4-τριαζολο-[3,4-b]-1,3,4-θειαδιαζολιων |
| CN109897054B (zh) * | 2017-12-08 | 2021-12-10 | 中国药科大学 | 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100883731B1 (ko) * | 2001-06-22 | 2009-02-12 | 기린 파마 가부시끼가이샤 | 간세포 증식 인자 수용체 자기 인산화를 저해하는 퀴놀린유도체 및 퀴나졸린 유도체 및 이들을 함유하는 의약 조성물 |
| UA86614C2 (ru) * | 2004-01-23 | 2009-05-12 | Амген Инк | Соединение, которое имеет активность ингибитора киназ, фармацевтическая композиция, которая включает указанное соединение, и их применение для приготовления лекарственного препарата |
| EA011725B1 (ru) * | 2004-08-26 | 2009-04-28 | Пфайзер Инк. | Пиразолзамещённые аминогетероарильные соединения в качестве ингибиторов протеинкиназы |
| AU2006320580B2 (en) * | 2005-11-30 | 2011-06-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Met and uses thereof |
| AU2008254588B2 (en) * | 2007-05-21 | 2013-01-17 | Sgx Pharmaceuticals, Inc. | Heterocyclic kinase modulators |
| US8217056B2 (en) * | 2008-11-19 | 2012-07-10 | Vertex Pharmaceuticals Incorporated | Triazolothiadiazole inhibitor of c-Met protein kinase |
| EP2435443B1 (en) * | 2009-05-28 | 2013-07-31 | Vertex Pharmaceuticals Incorporated | Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase |
-
2010
- 2010-05-27 CN CN2010800231025A patent/CN102448968A/zh active Pending
- 2010-05-27 JP JP2012513239A patent/JP2012528185A/ja active Pending
- 2010-05-27 AU AU2010254053A patent/AU2010254053A1/en not_active Abandoned
- 2010-05-27 US US12/788,608 patent/US8269012B2/en not_active Expired - Fee Related
- 2010-05-27 WO PCT/US2010/036309 patent/WO2010138663A1/en not_active Ceased
- 2010-05-27 US US12/788,715 patent/US8269013B2/en active Active
- 2010-05-27 CA CA2762186A patent/CA2762186A1/en not_active Abandoned
- 2010-05-27 EP EP10730618A patent/EP2435444A1/en not_active Withdrawn
- 2010-05-27 MX MX2011012522A patent/MX2011012522A/es not_active Application Discontinuation
-
2012
- 2012-09-17 US US13/621,396 patent/US20130018072A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012528185A (ja) | 2012-11-12 |
| US20100305155A1 (en) | 2010-12-02 |
| AU2010254053A1 (en) | 2011-12-01 |
| US8269013B2 (en) | 2012-09-18 |
| CA2762186A1 (en) | 2010-12-02 |
| US8269012B2 (en) | 2012-09-18 |
| EP2435444A1 (en) | 2012-04-04 |
| US20130018072A1 (en) | 2013-01-17 |
| CN102448968A (zh) | 2012-05-09 |
| US20110124684A1 (en) | 2011-05-26 |
| WO2010138663A1 (en) | 2010-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |