MX2011008662A - 2-mercapto-3-aminopiridinas sustituidas como moduladores de kcnq2/3. - Google Patents
2-mercapto-3-aminopiridinas sustituidas como moduladores de kcnq2/3.Info
- Publication number
- MX2011008662A MX2011008662A MX2011008662A MX2011008662A MX2011008662A MX 2011008662 A MX2011008662 A MX 2011008662A MX 2011008662 A MX2011008662 A MX 2011008662A MX 2011008662 A MX2011008662 A MX 2011008662A MX 2011008662 A MX2011008662 A MX 2011008662A
- Authority
- MX
- Mexico
- Prior art keywords
- aminopyridines
- mercapto
- substituted
- kcnq2
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09003604 | 2009-03-12 | ||
| PCT/EP2010/001508 WO2010102810A1 (fr) | 2009-03-12 | 2010-03-11 | 2-mercapto-3-aminopyridines substituées utilisées comme modulateurs des canaux kcnq2/3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011008662A true MX2011008662A (es) | 2011-09-06 |
Family
ID=40886174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011008662A MX2011008662A (es) | 2009-03-12 | 2010-03-11 | 2-mercapto-3-aminopiridinas sustituidas como moduladores de kcnq2/3. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8247573B2 (fr) |
| EP (1) | EP2406224B1 (fr) |
| JP (1) | JP5583148B2 (fr) |
| KR (1) | KR20110126751A (fr) |
| CN (1) | CN102341373A (fr) |
| AR (1) | AR078027A1 (fr) |
| AU (1) | AU2010223512B2 (fr) |
| BR (1) | BRPI1008963A2 (fr) |
| CA (1) | CA2755002A1 (fr) |
| CO (1) | CO6410290A2 (fr) |
| EC (1) | ECSP11011345A (fr) |
| ES (1) | ES2484371T3 (fr) |
| IL (1) | IL214947A0 (fr) |
| MX (1) | MX2011008662A (fr) |
| NZ (1) | NZ595627A (fr) |
| PE (1) | PE20120667A1 (fr) |
| RU (1) | RU2011141189A (fr) |
| TW (1) | TW201038565A (fr) |
| WO (1) | WO2010102810A1 (fr) |
| ZA (1) | ZA201107443B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI504395B (zh) * | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| AU2010223555A1 (en) * | 2009-03-10 | 2011-11-03 | Grünenthal GmbH | Substituted 3-aminoisoxazolopyridines as KCNQ2/3 modulators |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| NZ604745A (en) | 2010-08-27 | 2015-01-30 | Gruenenthal Chemie | Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators |
| EP2609086B1 (fr) | 2010-08-27 | 2015-02-25 | Grünenthal GmbH | 2-oxo- et 2-thioxo-dihydroquinoléine-3-carboxamides substitués comme modulateurs de kcnq2/3 |
| US8470852B2 (en) | 2010-08-27 | 2013-06-25 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators |
| MX2013002295A (es) | 2010-09-01 | 2013-05-09 | Gruenenthal Gmbh | 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
| KR101820645B1 (ko) * | 2010-10-20 | 2018-01-22 | 그뤼넨탈 게엠베하 | Ｋｃｎｑ２／３ 조절제로서의 치환된 ６아미노니코틴아미드 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2706977A1 (de) | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
| FR2532939A1 (fr) | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus |
| DE4032147A1 (de) | 1990-10-10 | 1992-04-16 | Bayer Ag | Verwendung von substituierten 2-mercaptonicotinsaeurederivaten zur bekaempfung von endoparasiten, neue substituierte 2-mercaptonicotinsaeurederivate und verfahren zu ihrer herstellung |
| EP0716077A1 (fr) | 1994-12-08 | 1996-06-12 | Ciba-Geigy Ag | Amides d'acides oméga-amino alcanoiques et diamides alcanoiques ayant un substituant aromatique et leur application en tant qu'inhibiteurs de leur rénine |
| WO1996026925A1 (fr) | 1995-03-01 | 1996-09-06 | Banyu Pharmaceutical Co., Ltd. | Derives de l'arylthioacetamide |
| DE19738616A1 (de) | 1997-09-04 | 1999-03-11 | Clariant Gmbh | 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel |
| WO2000042026A1 (fr) | 1999-01-15 | 2000-07-20 | Novo Nordisk A/S | Agonistes non peptidiques de glp-1 |
| DE60037321T4 (de) | 1999-08-04 | 2010-01-07 | Icagen, Inc. | Benzanilide als öffner des kaliumkanals |
| EP1200086A4 (fr) | 1999-08-04 | 2009-05-27 | Icagen Inc | Procedes therapeutiques ou prophylactiques de la douleur et de l'anxiete |
| EP1361879A1 (fr) | 2001-02-20 | 2003-11-19 | Bristol-Myers Squibb Company | Derives de 2,4-disubstitue pyrimidine-5-carboxamide en tant que modulateur des canaux potassium kcnq |
| MXPA03007397A (es) | 2001-02-20 | 2003-12-04 | Bristol Myers Squibb Co | Moduladores de canales de potasio kcnq y uso de los mismos en tratamiento de migrana y enfermedades mecanicamente relacionadas. |
| US6593349B2 (en) | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
| WO2002081728A2 (fr) | 2001-04-06 | 2002-10-17 | Smithkline Beecham Corporation | Inhibiteurs quinoline des kinases hyak1 et hyak3 |
| BR0314390A (pt) | 2002-09-17 | 2005-07-19 | Pharmacia Corp | Moduladores aromáticos dos receptores hepáticos x |
| EP1585522B1 (fr) | 2002-12-23 | 2010-11-17 | Icagen, Inc. | Quinazolinones comme modulateurs de canaux potassiques |
| EP1449841A1 (fr) | 2003-02-19 | 2004-08-25 | Bayer CropScience SA | Nouveaux composés fungicides |
| RU2006115602A (ru) | 2003-10-08 | 2007-11-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы переносчиков атф-связывающих кассет |
| WO2005105733A1 (fr) | 2004-05-04 | 2005-11-10 | Pfizer Japan Inc. | Composes aryl- ou heteroarylamides ortho-substitues |
| CA2585490A1 (fr) | 2004-11-12 | 2006-05-18 | Galapagos Nv | Composes heteroaromatiques de l'azote qui se lient au site actif d'enzymes de type proteines kinases |
| EP1861394A1 (fr) * | 2005-03-03 | 2007-12-05 | H.Lundbeck A/S | Derives de pyridine substitues |
| DE102005038947A1 (de) | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| DE602006007012D1 (de) | 2005-07-20 | 2009-07-09 | Lilly Co Eli | Pyridinderivate als dipeptedyl-peptidase-hemmer |
| EP1922311A2 (fr) | 2005-09-09 | 2008-05-21 | Brystol-Myers Squibb Company | Inhibiteurs d'ikur acycliques |
| JP2009515934A (ja) | 2005-11-18 | 2009-04-16 | ノイロサーチ アクティーゼルスカブ | 新規なキナゾリン誘導体及びこれらの医学的使用 |
| AU2007275683B2 (en) | 2006-07-20 | 2012-05-10 | Amgen Inc. | Di-amino-substituted heterocyclic compounds and methods of use |
| ES2338278T3 (es) | 2006-07-20 | 2010-05-05 | Amgen Inc. | Derivados de benzo(d)isoxazol como inhibidores de c-kit tirosina quinasa para el tratamiento de enfermedades asociadas con la sobreproduccion de histamina. |
| WO2008012532A2 (fr) | 2006-07-27 | 2008-01-31 | Astrazeneca Ab | Composés chimiques 428 |
| DE102006049452A1 (de) | 2006-10-17 | 2008-05-08 | Grünenthal GmbH | Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| CN101784515A (zh) | 2007-08-03 | 2010-07-21 | 弗·哈夫曼-拉罗切有限公司 | 作为taar1配体的吡啶甲酰胺和苯甲酰胺衍生物 |
| US8299123B2 (en) | 2007-10-19 | 2012-10-30 | Boehringer Ingelheim International Gmbh | CCR10 antagonists |
| TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| AU2010223555A1 (en) | 2009-03-10 | 2011-11-03 | Grünenthal GmbH | Substituted 3-aminoisoxazolopyridines as KCNQ2/3 modulators |
| TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier |
-
2010
- 2010-02-12 TW TW099104569A patent/TW201038565A/zh unknown
- 2010-03-10 US US12/720,836 patent/US8247573B2/en not_active Expired - Fee Related
- 2010-03-11 PE PE2011001596A patent/PE20120667A1/es not_active Application Discontinuation
- 2010-03-11 BR BRPI1008963A patent/BRPI1008963A2/pt not_active IP Right Cessation
- 2010-03-11 ES ES10708140.8T patent/ES2484371T3/es active Active
- 2010-03-11 RU RU2011141189/04A patent/RU2011141189A/ru not_active Application Discontinuation
- 2010-03-11 KR KR1020117023786A patent/KR20110126751A/ko not_active Application Discontinuation
- 2010-03-11 NZ NZ595627A patent/NZ595627A/xx not_active IP Right Cessation
- 2010-03-11 WO PCT/EP2010/001508 patent/WO2010102810A1/fr active Application Filing
- 2010-03-11 MX MX2011008662A patent/MX2011008662A/es active IP Right Grant
- 2010-03-11 JP JP2011553351A patent/JP5583148B2/ja not_active Expired - Fee Related
- 2010-03-11 CA CA2755002A patent/CA2755002A1/fr not_active Abandoned
- 2010-03-11 CN CN2010800106472A patent/CN102341373A/zh active Pending
- 2010-03-11 EP EP10708140.8A patent/EP2406224B1/fr not_active Not-in-force
- 2010-03-11 AU AU2010223512A patent/AU2010223512B2/en not_active Ceased
- 2010-03-12 AR ARP100100779A patent/AR078027A1/es not_active Application Discontinuation
-
2011
- 2011-09-02 CO CO11113005A patent/CO6410290A2/es not_active Application Discontinuation
- 2011-09-04 IL IL214947A patent/IL214947A0/en unknown
- 2011-09-23 EC EC2011011345A patent/ECSP11011345A/es unknown
- 2011-10-11 ZA ZA2011/07443A patent/ZA201107443B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010223512B2 (en) | 2015-01-22 |
| RU2011141189A (ru) | 2013-04-20 |
| WO2010102810A1 (fr) | 2010-09-16 |
| AR078027A1 (es) | 2011-10-12 |
| EP2406224A1 (fr) | 2012-01-18 |
| BRPI1008963A2 (pt) | 2016-03-15 |
| JP5583148B2 (ja) | 2014-09-03 |
| CO6410290A2 (es) | 2012-03-30 |
| CN102341373A (zh) | 2012-02-01 |
| IL214947A0 (en) | 2011-11-30 |
| ZA201107443B (en) | 2012-07-25 |
| AU2010223512A1 (en) | 2011-11-03 |
| EP2406224B1 (fr) | 2014-04-23 |
| NZ595627A (en) | 2012-10-26 |
| US8247573B2 (en) | 2012-08-21 |
| ECSP11011345A (es) | 2011-10-31 |
| JP2012520248A (ja) | 2012-09-06 |
| TW201038565A (en) | 2010-11-01 |
| KR20110126751A (ko) | 2011-11-23 |
| CA2755002A1 (fr) | 2010-09-16 |
| US20100234428A1 (en) | 2010-09-16 |
| ES2484371T3 (es) | 2014-08-11 |
| PE20120667A1 (es) | 2012-06-01 |
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