MX2011006677A - Proceso para purificar mezcla de polimero. - Google Patents

Proceso para purificar mezcla de polimero.

Info

Publication number
MX2011006677A
MX2011006677A MX2011006677A MX2011006677A MX2011006677A MX 2011006677 A MX2011006677 A MX 2011006677A MX 2011006677 A MX2011006677 A MX 2011006677A MX 2011006677 A MX2011006677 A MX 2011006677A MX 2011006677 A MX2011006677 A MX 2011006677A
Authority
MX
Mexico
Prior art keywords
ultrafiltration
acid
polypeptide
purifying
polymer mixture
Prior art date
Application number
MX2011006677A
Other languages
English (en)
Other versions
MX338074B (es
Inventor
Jordy Luten
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of MX2011006677A publication Critical patent/MX2011006677A/es
Publication of MX338074B publication Critical patent/MX338074B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Water Supply & Treatment (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

Un proceso para purificar péptidos de copolímero tales como polipéptidos de COP-l mediante una ultrafiltración, puede ser mejorado al tratar la solución de polipéptido con un ácido antes o durante las primeras etapas de la ultrafiltración. La agregación del ácido y/o formación de sales de adición de ácido del polipéptido antes de que sea conducida la ultrafiltración, permite una ultrafiltración más rápida. De igual forma, agregar el ácido en el proceso de ultrafiltración, pero antes de que ocurra la precipitación de polipéptido o una obstrucción también puede mejorar la eficiencia / conveniencia del paso de ultrafiltración.
MX2011006677A 2008-12-24 2009-12-24 Proceso para purificar mezcla de polimero. MX338074B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14075108P 2008-12-24 2008-12-24
PCT/EP2009/009272 WO2010072418A1 (en) 2008-12-24 2009-12-24 A process for purifying a polymer mixture

Publications (2)

Publication Number Publication Date
MX2011006677A true MX2011006677A (es) 2011-09-15
MX338074B MX338074B (es) 2016-04-01

Family

ID=41795365

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011006677A MX338074B (es) 2008-12-24 2009-12-24 Proceso para purificar mezcla de polimero.

Country Status (17)

Country Link
US (1) US9617313B2 (es)
EP (2) EP2796463A1 (es)
KR (1) KR20110112366A (es)
AR (1) AR074881A1 (es)
AU (1) AU2009331841A1 (es)
BR (1) BRPI0922337A2 (es)
CL (1) CL2011001565A1 (es)
CO (1) CO6382160A2 (es)
EA (1) EA019910B1 (es)
EC (1) ECSP11011187A (es)
ES (1) ES2584529T3 (es)
HU (1) HUE028250T2 (es)
MX (1) MX338074B (es)
PL (1) PL2382233T3 (es)
PT (1) PT2382233T (es)
WO (1) WO2010072418A1 (es)
ZA (1) ZA201104565B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2307448T3 (pl) * 2008-08-07 2015-10-30 Sigma Aldrich Co Llc Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością
US8575198B1 (en) 2011-09-07 2013-11-05 Momenta Pharmaceuticals, Inc. In-process control for the manufacture of glatiramer acetate

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2657972A (en) * 1952-09-06 1953-11-03 Robert B Woodward Copolymer of l-leucine and dl-phenylalanine
IL36670A (en) * 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids
FR2182667B1 (es) * 1972-05-03 1978-03-03 Rhone Poulenc Ind
CA2009996A1 (en) 1989-02-17 1990-08-17 Kathleen S. Cook Process for making genes encoding random polymers of amino acids
US5800808A (en) * 1994-05-24 1998-09-01 Veda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
SI1797109T1 (sl) * 2004-09-09 2016-07-29 Yeda Research And Development Co., Ltd. Zmesi polipeptidov, sestavki, ki jih vsebujejo, in postopki za njihovo pripravo ter njihove uporabe
CA2583589C (en) 2004-10-29 2012-04-24 Sandoz Ag Processes for preparing glatiramer
MX2007009296A (es) 2005-02-02 2007-09-21 Teva Pharma Proceso para producir mezclas de polipeptidos usando hidrogenolisis.
SI2046817T1 (sl) * 2006-07-05 2010-04-30 Momenta Pharmaceuticals Inc Izboljšani postopek za pripravo kopolimera-1

Also Published As

Publication number Publication date
ZA201104565B (en) 2012-09-26
PL2382233T3 (pl) 2017-03-31
CL2011001565A1 (es) 2012-01-13
US20100160606A1 (en) 2010-06-24
EA201170881A1 (ru) 2012-01-30
PT2382233T (pt) 2016-08-08
EA019910B1 (ru) 2014-07-30
KR20110112366A (ko) 2011-10-12
BRPI0922337A2 (pt) 2016-11-29
WO2010072418A1 (en) 2010-07-01
HUE028250T2 (en) 2016-12-28
ECSP11011187A (es) 2011-08-31
EP2796463A1 (en) 2014-10-29
EP2382233B1 (en) 2016-05-11
EP2382233A1 (en) 2011-11-02
ES2584529T3 (es) 2016-09-28
US9617313B2 (en) 2017-04-11
AR074881A1 (es) 2011-02-16
AU2009331841A1 (en) 2011-07-07
CO6382160A2 (es) 2012-02-15
MX338074B (es) 2016-04-01

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