EA201170881A1 - Способ очистки полимерной смеси - Google Patents

Способ очистки полимерной смеси

Info

Publication number
EA201170881A1
EA201170881A1 EA201170881A EA201170881A EA201170881A1 EA 201170881 A1 EA201170881 A1 EA 201170881A1 EA 201170881 A EA201170881 A EA 201170881A EA 201170881 A EA201170881 A EA 201170881A EA 201170881 A1 EA201170881 A1 EA 201170881A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ultrafiltration
acid
polypeptide
addition
polymeric mixture
Prior art date
Application number
EA201170881A
Other languages
English (en)
Other versions
EA019910B1 (ru
Inventor
Йорди Лютен
Original Assignee
Синтон Бв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Синтон Бв filed Critical Синтон Бв
Publication of EA201170881A1 publication Critical patent/EA201170881A1/ru
Publication of EA019910B1 publication Critical patent/EA019910B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Polymers & Plastics (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

Способ очистки сополимерных пептидов, таких как полипептиды СОП-I, в результате ультрафильтрации может быть улучшен в результате обработки раствора полипептида кислотой до или во время ранних ступеней ультрафильтрации. Добавление кислоты и/или получение кислотно-аддитивных солей полипептида до ультрафильтрации проводят для обеспечения более быстрой ультрафильтрации. Подобным образом добавление кислоты в способе ультрафильтрации, но до возникновения осаждения полипептида или закупоривания также может улучшить и эффективность/удобство стадии ультрафильтрации.
EA201170881A 2008-12-24 2009-12-24 Способ очистки полимерной смеси EA019910B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14075108P 2008-12-24 2008-12-24
PCT/EP2009/009272 WO2010072418A1 (en) 2008-12-24 2009-12-24 A process for purifying a polymer mixture

Publications (2)

Publication Number Publication Date
EA201170881A1 true EA201170881A1 (ru) 2012-01-30
EA019910B1 EA019910B1 (ru) 2014-07-30

Family

ID=41795365

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170881A EA019910B1 (ru) 2008-12-24 2009-12-24 Способ очистки полимерной смеси

Country Status (17)

Country Link
US (1) US9617313B2 (ru)
EP (2) EP2796463A1 (ru)
KR (1) KR20110112366A (ru)
AR (1) AR074881A1 (ru)
AU (1) AU2009331841A1 (ru)
BR (1) BRPI0922337A2 (ru)
CL (1) CL2011001565A1 (ru)
CO (1) CO6382160A2 (ru)
EA (1) EA019910B1 (ru)
EC (1) ECSP11011187A (ru)
ES (1) ES2584529T3 (ru)
HU (1) HUE028250T2 (ru)
MX (1) MX338074B (ru)
PL (1) PL2382233T3 (ru)
PT (1) PT2382233T (ru)
WO (1) WO2010072418A1 (ru)
ZA (1) ZA201104565B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2307448T3 (pl) * 2008-08-07 2015-10-30 Sigma Aldrich Co Llc Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością
US8575198B1 (en) 2011-09-07 2013-11-05 Momenta Pharmaceuticals, Inc. In-process control for the manufacture of glatiramer acetate

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2657972A (en) * 1952-09-06 1953-11-03 Robert B Woodward Copolymer of l-leucine and dl-phenylalanine
IL36670A (en) * 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids
FR2182667B1 (ru) * 1972-05-03 1978-03-03 Rhone Poulenc Ind
CA2009996A1 (en) 1989-02-17 1990-08-17 Kathleen S. Cook Process for making genes encoding random polymers of amino acids
US5800808A (en) * 1994-05-24 1998-09-01 Veda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
WO2006029411A2 (en) * 2004-09-09 2006-03-16 Yeda Research And Development Co. Ltd. Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof
AR052321A1 (es) * 2004-10-29 2007-03-14 Sandoz Ag Procesos para la preparacion de un polipeptido
US20060172942A1 (en) 2005-02-02 2006-08-03 Teva Pharmaceutical Industries, Ltd. Process for producing polypeptide mixtures using hydrogenolysis
AU2007269140A1 (en) * 2006-07-05 2008-01-10 Momenta Pharmaceuticals, Inc. Improved process for the preparation of copolymer-1

Also Published As

Publication number Publication date
ECSP11011187A (es) 2011-08-31
US9617313B2 (en) 2017-04-11
EP2382233A1 (en) 2011-11-02
EP2382233B1 (en) 2016-05-11
MX2011006677A (es) 2011-09-15
AR074881A1 (es) 2011-02-16
US20100160606A1 (en) 2010-06-24
PL2382233T3 (pl) 2017-03-31
CL2011001565A1 (es) 2012-01-13
PT2382233T (pt) 2016-08-08
AU2009331841A1 (en) 2011-07-07
WO2010072418A1 (en) 2010-07-01
KR20110112366A (ko) 2011-10-12
ES2584529T3 (es) 2016-09-28
MX338074B (es) 2016-04-01
ZA201104565B (en) 2012-09-26
EA019910B1 (ru) 2014-07-30
CO6382160A2 (es) 2012-02-15
BRPI0922337A2 (pt) 2016-11-29
HUE028250T2 (en) 2016-12-28
EP2796463A1 (en) 2014-10-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KG MD TJ TM

QB4A Registration of a licence in a contracting state
QB4A Registration of a licence in a contracting state
TK4A Corrections in published eurasian patents