MX2011004719A - Virus sincitial respiratorio vivo atenuado. - Google Patents
Virus sincitial respiratorio vivo atenuado.Info
- Publication number
- MX2011004719A MX2011004719A MX2011004719A MX2011004719A MX2011004719A MX 2011004719 A MX2011004719 A MX 2011004719A MX 2011004719 A MX2011004719 A MX 2011004719A MX 2011004719 A MX2011004719 A MX 2011004719A MX 2011004719 A MX2011004719 A MX 2011004719A
- Authority
- MX
- Mexico
- Prior art keywords
- gene
- nucleotide
- protein encoded
- amino acid
- mutation
- Prior art date
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- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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- C—CHEMISTRY; METALLURGY
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
- C12N2760/18564—Methods of inactivation or attenuation by serial passage
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Applications Claiming Priority (2)
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| US19832708P | 2008-11-05 | 2008-11-05 | |
| PCT/US2009/063024 WO2010053883A1 (en) | 2008-11-05 | 2009-11-03 | Live, attentuated respiratory syncytial virus |
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| MX2011004719A true MX2011004719A (es) | 2011-05-31 |
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| MX2011004719A MX2011004719A (es) | 2008-11-05 | 2009-11-03 | Virus sincitial respiratorio vivo atenuado. |
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| BRPI0921424A2 (pt) * | 2008-11-05 | 2016-01-05 | Merck Sharp & Dohme | vírus sincicial respiratório atenuado, composição imunogênica, molécula de ácido nucléico, célula recombinante, método para produzir uma resposta imune protetiva em um paciente, e, uso de uma quantidade imunologicamente eficaz de um ou mais dos seguintes: um rsv atenuado, uma população de rsv atenuado e uma composição imunogênica. |
| WO2013026054A2 (en) * | 2011-08-18 | 2013-02-21 | Axella Solutions, Llc | Production of infectious rna viruses in yeast |
| US9463236B2 (en) | 2011-08-29 | 2016-10-11 | Tokushima University | RSV mucosal vaccine |
| CA2900713A1 (en) | 2013-02-08 | 2014-08-14 | Steffen Mueller | Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization |
| CN105189756B (zh) * | 2013-03-14 | 2021-06-11 | 爱默蕾大学 | 具有沉默突变的重组rsv、其相关疫苗和方法 |
| EP3057978B1 (en) | 2013-10-16 | 2022-09-14 | Merck Sharp & Dohme LLC | Method of microwave vacuum drying spherical-shaped pellets of biological materials |
| WO2015057548A1 (en) | 2013-10-16 | 2015-04-23 | Merck Sharp & Dohme Corp | Thermostable respiratory synctial virus (rsv) vaccine compositions |
| US10947512B2 (en) * | 2015-08-14 | 2021-03-16 | Research Institute At Nationwide Children's Hospital | Respiratory syncytial virus having altered NS1 protein function and related materials and methods |
| SG11201803581VA (en) | 2015-10-29 | 2018-05-30 | Univ Emory | Chimeric RSV, Immunogenic Compositions, and Methods of Use |
| AU2017332789B2 (en) | 2016-09-23 | 2021-05-27 | Codagenix, Inc. | Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes |
| TWI911431B (zh) | 2017-03-01 | 2026-01-11 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
| EP3681523A4 (en) * | 2017-09-15 | 2021-12-29 | The Ohio State Innovation Foundation | Vaccines and methods of making and using vaccines for prevention of respiratory syncytial virus (rsv) infections |
| AU2024380679A1 (en) * | 2023-11-17 | 2026-07-02 | Sanofi Vaccines US Inc. | Trehalose vaccine formulation |
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| EP0917592A4 (en) * | 1996-04-04 | 2002-04-24 | Univ Michigan | REDUCED RSV |
| IL138681A0 (en) | 1998-03-26 | 2001-10-31 | American Cyanamid Co | Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup b |
| CN101260386A (zh) | 1999-07-09 | 2008-09-10 | 美国政府健康及人类服务部 | 减毒的人-牛嵌合呼吸道合胞病毒疫苗的生产 |
| JP2007531491A (ja) | 2002-09-27 | 2007-11-08 | メディミューン・ヴァクシンズ・インコーポレーテッド | 呼吸器合胞体ウイルスにおける機能的突然変異 |
| WO2004087062A2 (en) * | 2003-03-28 | 2004-10-14 | Medimmune Vaccines, Inc. | Compositions and methods involving respiratory syncytial virus subgroup b strain 9320 |
| KR20090114431A (ko) * | 2007-02-07 | 2009-11-03 | 디나벡크 가부시키가이샤 | 약독화 마이너스 가닥 ｒｎａ 바이러스 |
| BRPI0921424A2 (pt) * | 2008-11-05 | 2016-01-05 | Merck Sharp & Dohme | vírus sincicial respiratório atenuado, composição imunogênica, molécula de ácido nucléico, célula recombinante, método para produzir uma resposta imune protetiva em um paciente, e, uso de uma quantidade imunologicamente eficaz de um ou mais dos seguintes: um rsv atenuado, uma população de rsv atenuado e uma composição imunogênica. |
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2009
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- 2009-11-03 WO PCT/US2009/063024 patent/WO2010053883A1/en not_active Ceased
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- 2009-11-03 CA CA2742086A patent/CA2742086A1/en not_active Abandoned
- 2009-11-03 US US13/127,647 patent/US9011876B2/en active Active
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- 2009-11-03 JP JP2011534864A patent/JP5016731B2/ja not_active Expired - Fee Related
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2011
- 2011-04-17 IL IL212437A patent/IL212437A0/en unknown
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- 2011-06-03 MA MA33913A patent/MA32878B1/fr unknown
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| IL212437A0 (en) | 2011-06-30 |
| EP2346990A1 (en) | 2011-07-27 |
| CN102272295A (zh) | 2011-12-07 |
| CA2742086A1 (en) | 2010-05-14 |
| ECSP11011033A (es) | 2011-12-30 |
| AU2009311287C1 (en) | 2015-02-19 |
| JP5743794B2 (ja) | 2015-07-01 |
| KR20110063863A (ko) | 2011-06-14 |
| JP2011250798A (ja) | 2011-12-15 |
| TN2011000182A1 (en) | 2012-12-17 |
| AU2009311287A1 (en) | 2010-05-14 |
| BRPI0921424A2 (pt) | 2016-01-05 |
| JP5016731B2 (ja) | 2012-09-05 |
| CO6362047A2 (es) | 2012-01-20 |
| ZA201103259B (en) | 2012-01-25 |
| RU2011122615A (ru) | 2012-12-20 |
| MA32878B1 (fr) | 2011-12-01 |
| AU2009311287B2 (en) | 2013-02-07 |
| CL2011000999A1 (es) | 2012-07-20 |
| PE20110394A1 (es) | 2011-06-22 |
| US9011876B2 (en) | 2015-04-21 |
| WO2010053883A1 (en) | 2010-05-14 |
| JP2012507302A (ja) | 2012-03-29 |
| US20110212130A1 (en) | 2011-09-01 |
| EP2346990B1 (en) | 2016-01-06 |
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