MX2010001556A - Nuevo procedimiento de sintesis de derivados anticancerosos de (poli) aminoalquilaminoacetamida de epipodofilotoxina. - Google Patents

Nuevo procedimiento de sintesis de derivados anticancerosos de (poli) aminoalquilaminoacetamida de epipodofilotoxina.

Info

Publication number
MX2010001556A
MX2010001556A MX2010001556A MX2010001556A MX2010001556A MX 2010001556 A MX2010001556 A MX 2010001556A MX 2010001556 A MX2010001556 A MX 2010001556A MX 2010001556 A MX2010001556 A MX 2010001556A MX 2010001556 A MX2010001556 A MX 2010001556A
Authority
MX
Mexico
Prior art keywords
epipodophyllotoxin
poly
novel method
anticancer
aminoalkylamin
Prior art date
Application number
MX2010001556A
Other languages
English (en)
Inventor
Thierry Imbert
Yves Guminski
Martial Grousseaud
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of MX2010001556A publication Critical patent/MX2010001556A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención describe un nuevo procedimiento de preparación de los compuestos (poli)aminoalquilaminoacetamida de epipodofilotoxina, útiles por sus aplicaciones en terapéutica como agentes anticancerosos. Este procedimiento comprende una etapa de condensación de un reactivo con grupos aminos primarios cuyas funciones amino no están protegidas con la 4ß-cloroacetamido-4'-epipodofilotoxina en un disolvente orgánico polar aprótico.
MX2010001556A 2007-09-25 2008-09-23 Nuevo procedimiento de sintesis de derivados anticancerosos de (poli) aminoalquilaminoacetamida de epipodofilotoxina. MX2010001556A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0706692A FR2921368B1 (fr) 2007-09-25 2007-09-25 Nouveau procede de synthese de derives anticancereux de (poly) aminoalkylaminoacetamide d'epipodophyllotoxine.
PCT/FR2008/051697 WO2009050363A1 (fr) 2007-09-25 2008-09-23 Procede de synthese de derives anticancereux de ( poly) aminoalkylaminoacetamide d ' epipodophyllotoxine

Publications (1)

Publication Number Publication Date
MX2010001556A true MX2010001556A (es) 2010-03-15

Family

ID=39322470

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001556A MX2010001556A (es) 2007-09-25 2008-09-23 Nuevo procedimiento de sintesis de derivados anticancerosos de (poli) aminoalquilaminoacetamida de epipodofilotoxina.

Country Status (19)

Country Link
US (1) US8148552B2 (es)
EP (1) EP2203455B1 (es)
JP (1) JP5420549B2 (es)
KR (1) KR101336921B1 (es)
CN (1) CN101809022B (es)
AU (1) AU2008313616B2 (es)
BR (1) BRPI0817326A2 (es)
CA (1) CA2700161C (es)
FR (1) FR2921368B1 (es)
HK (1) HK1143361A1 (es)
IL (1) IL204636A (es)
MA (1) MA31689B1 (es)
MX (1) MX2010001556A (es)
MY (1) MY146171A (es)
NZ (1) NZ583814A (es)
RU (1) RU2450009C2 (es)
TN (1) TN2010000095A1 (es)
WO (1) WO2009050363A1 (es)
ZA (1) ZA201001265B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2624903C1 (ru) * 2016-11-02 2017-07-10 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Производные ванилина с противоопухолевой активностью

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066737A (en) 1990-10-22 1991-11-19 Shell Oil Company Olefin polymerization catalyst
SU598871A1 (ru) 1976-07-26 1978-03-25 Всесоюзный научно-исследовательский институт технологии кровезаменителей и гормональных препаратов Способ получени гидрохлорида метиламиноацетопирокатехина
US4612299A (en) 1984-07-09 1986-09-16 Amoco Corporation Magnesium carboxylate supports
US5567665A (en) 1994-03-31 1996-10-22 Union Carbide Chemicals & Plastics Technology Corporation Shape-shifted magnesium alkoxide component for polymerizing olefins
US4579836A (en) 1985-05-22 1986-04-01 Amoco Corporation Exhaustively prepolymerized supported alpha-olefin polymerization catalyst
CN1068330A (zh) * 1991-07-03 1993-01-27 国家医药管理局上海医药工业研究院 4-氮取代-4-脱氧-4′-去甲表鬼臼毒素衍生物及其合成方法
US6051666A (en) 1995-04-10 2000-04-18 Dsm N.V. Method for preparing a catalyst suitable for polymerizing an olefin
FR2742439B1 (fr) * 1995-12-14 1998-03-06 Pf Medicament Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine
WO1998045338A1 (en) 1997-04-07 1998-10-15 Engelhard Corporation Modification of polymer molecular weight distribution by using mixed silane systems in high activity polymerization catalysts
JP4717219B2 (ja) 1999-04-15 2011-07-06 バセル テクノロジー カンパニー ビー．ブイ． オレフィン重合用の成分および触媒
US6914153B2 (en) 2001-06-07 2005-07-05 Bassell Poliolefine Italia S.P.A. Process for preparing alkylidene substituted succinic acid esters
EP1336625A1 (en) 2002-02-14 2003-08-20 Novolen Technology Holdings C.V. Solid catalytic component and catalytic system of the Ziegler-Natta type, process for their preparation and their use in the polymerisation of alk-1-enes
EP1599485A2 (en) * 2003-02-18 2005-11-30 Ranbaxy Laboratories, Ltd. Podophyllotoxin derivatives as antitumor agents
FR2869035B1 (fr) * 2004-04-16 2006-07-14 Pierre Fabre Medicament Sa Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine

Also Published As

Publication number Publication date
RU2010116166A (ru) 2011-11-10
FR2921368B1 (fr) 2012-10-12
TN2010000095A1 (fr) 2011-09-26
NZ583814A (en) 2012-01-12
JP2010540505A (ja) 2010-12-24
JP5420549B2 (ja) 2014-02-19
AU2008313616A1 (en) 2009-04-23
BRPI0817326A2 (pt) 2015-03-24
FR2921368A1 (fr) 2009-03-27
CA2700161A1 (fr) 2009-04-23
WO2009050363A1 (fr) 2009-04-23
MA31689B1 (fr) 2010-09-01
ZA201001265B (en) 2010-11-24
IL204636A (en) 2013-11-28
RU2450009C2 (ru) 2012-05-10
KR20100058536A (ko) 2010-06-03
US8148552B2 (en) 2012-04-03
EP2203455B1 (fr) 2017-08-30
AU2008313616B2 (en) 2012-01-19
CN101809022B (zh) 2012-07-04
IL204636A0 (en) 2010-11-30
MY146171A (en) 2012-07-13
KR101336921B1 (ko) 2013-12-04
US20100280263A1 (en) 2010-11-04
CN101809022A (zh) 2010-08-18
EP2203455A1 (fr) 2010-07-07
HK1143361A1 (en) 2010-12-31
CA2700161C (fr) 2013-11-19

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