MX2009013205A - Derivados de pirazoloquinolina urea terapeuticos. - Google Patents
Derivados de pirazoloquinolina urea terapeuticos.Info
- Publication number
- MX2009013205A MX2009013205A MX2009013205A MX2009013205A MX2009013205A MX 2009013205 A MX2009013205 A MX 2009013205A MX 2009013205 A MX2009013205 A MX 2009013205A MX 2009013205 A MX2009013205 A MX 2009013205A MX 2009013205 A MX2009013205 A MX 2009013205A
- Authority
- MX
- Mexico
- Prior art keywords
- gabaa
- formula
- urea derivatives
- animal
- compound
- Prior art date
Links
- PBUWKCRTSMWDRY-UHFFFAOYSA-N NC(N)=O.C1=CNC2=C3C=NN=C3C=CC2=C1 Chemical class NC(N)=O.C1=CNC2=C3C=NN=C3C=CC2=C1 PBUWKCRTSMWDRY-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 2
- 108091008681 GABAA receptors Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94299207P | 2007-06-08 | 2007-06-08 | |
| PCT/US2008/066205 WO2008154442A1 (en) | 2007-06-08 | 2008-06-06 | Therapeutic pyrazoloquinoline urea derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009013205A true MX2009013205A (es) | 2010-04-09 |
Family
ID=40096439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009013205A MX2009013205A (es) | 2007-06-08 | 2008-06-06 | Derivados de pirazoloquinolina urea terapeuticos. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7863266B2 (enExample) |
| EP (1) | EP2164328B8 (enExample) |
| JP (1) | JP2010529144A (enExample) |
| KR (1) | KR20100038189A (enExample) |
| CN (1) | CN101686682A (enExample) |
| AU (1) | AU2008261888A1 (enExample) |
| BR (1) | BRPI0812347A2 (enExample) |
| CA (1) | CA2688405A1 (enExample) |
| ES (1) | ES2433566T3 (enExample) |
| IL (1) | IL202286A0 (enExample) |
| MX (1) | MX2009013205A (enExample) |
| WO (1) | WO2008154442A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8927546B2 (en) * | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| US7863266B2 (en) * | 2007-06-08 | 2011-01-04 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline urea derivatives |
| EP2490692B1 (en) * | 2009-10-21 | 2016-11-16 | Merck Sharp & Dohme Corp. | Quinolinone-pyrazolone m1 receptor positive allosteric modulators |
| FR2962335B1 (fr) * | 2010-07-12 | 2013-01-18 | Cll Pharma | Utilisation du nonapeptide pat dans le traitement et la prevention des maladies neurodegeneratives |
| US9468662B2 (en) | 2010-07-12 | 2016-10-18 | Orphit | Use of the PAT nonapeptide in the treatment and prevention of neurodegenerative diseases |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| CN106187887B (zh) * | 2016-07-01 | 2018-08-14 | 上海工程技术大学 | 4-羟基喹啉-3-甲酸的制备方法 |
| CN109890793B (zh) | 2016-11-11 | 2022-11-18 | 拜耳动物保健有限责任公司 | 新的抗蠕虫药喹啉-3-甲酰胺衍生物 |
| JP7403472B2 (ja) | 2018-05-09 | 2023-12-22 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規キノリン誘導体 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CY1357A (en) * | 1979-06-21 | 1987-08-07 | Ciba Geigy Ag | Pyrazolo-quinolines, processes for their production, pharmaceutical compositions containing them and their therapeutical use |
| DE3204126A1 (de) | 1982-02-06 | 1983-08-11 | Bayer Ag, 5090 Leverkusen | Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4524146A (en) * | 1982-12-08 | 1985-06-18 | Ciba-Geigy Corporation | Certain -2-heterocycle substituted pyrazoloquinolines |
| US4814450A (en) | 1984-07-09 | 1989-03-21 | Ciba-Geigy Corporation | Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives |
| JPS61112075A (ja) | 1984-11-05 | 1986-05-30 | Shionogi & Co Ltd | チエニルピラゾロキノリン誘導体 |
| EP0214092A1 (en) | 1985-08-08 | 1987-03-11 | Ciba-Geigy Ag | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
| KR100207360B1 (ko) * | 1991-06-14 | 1999-07-15 | 돈 더블유. 슈미츠 | 이미다조[1,5,-a]퀸옥살린 |
| US5334595A (en) | 1992-10-23 | 1994-08-02 | Sterling Winthrop Inc. | Pyrazoloquinolones as anticancer agents |
| US5792766A (en) * | 1996-03-13 | 1998-08-11 | Neurogen Corporation | Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands |
| GB9716344D0 (en) * | 1997-08-01 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic compounds |
| GB9716345D0 (en) * | 1997-08-01 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic compounds |
| GB9716347D0 (en) * | 1997-08-01 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic compounds |
| TWI271406B (en) | 1999-12-13 | 2007-01-21 | Eisai Co Ltd | Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same |
| ATE337322T1 (de) * | 2001-02-21 | 2006-09-15 | Janssen Pharmaceutica Nv | Isoxazolin-derivate als antidepressiva |
| JP3896309B2 (ja) | 2001-07-09 | 2007-03-22 | ファイザー株式会社 | プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体 |
| EP1572689B1 (en) | 2002-12-16 | 2009-03-11 | Active Biotech AB | Tetracyclic immunomodulatory compounds |
| US20050245563A1 (en) | 2003-05-29 | 2005-11-03 | Millennium Pharmaceuticals, Inc. | Chk-1 inhibitors |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| US20070078083A1 (en) | 2005-09-07 | 2007-04-05 | Braincells, Inc. | MODULATION OF NEUORGENESIS BY HDac INHIBITION |
| EP2612854B1 (en) * | 2005-10-25 | 2015-04-29 | Shionogi&Co., Ltd. | Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors |
| ATE544344T1 (de) * | 2007-06-08 | 2012-02-15 | Helicon Therapeutics Inc | Therapeutische pyrazolochinolinderivate |
| ES2483728T3 (es) * | 2007-06-08 | 2014-08-07 | Dart Neuroscience (Cayman) Ltd | Derivados terapéuticos de pirazolonafatiridina |
| US7863266B2 (en) * | 2007-06-08 | 2011-01-04 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline urea derivatives |
-
2008
- 2008-06-06 US US12/135,023 patent/US7863266B2/en not_active Expired - Fee Related
- 2008-06-06 KR KR1020107000233A patent/KR20100038189A/ko not_active Withdrawn
- 2008-06-06 AU AU2008261888A patent/AU2008261888A1/en not_active Abandoned
- 2008-06-06 ES ES08770406T patent/ES2433566T3/es active Active
- 2008-06-06 JP JP2010511389A patent/JP2010529144A/ja active Pending
- 2008-06-06 CA CA002688405A patent/CA2688405A1/en not_active Abandoned
- 2008-06-06 BR BRPI0812347A patent/BRPI0812347A2/pt not_active IP Right Cessation
- 2008-06-06 WO PCT/US2008/066205 patent/WO2008154442A1/en not_active Ceased
- 2008-06-06 CN CN200880023876A patent/CN101686682A/zh active Pending
- 2008-06-06 MX MX2009013205A patent/MX2009013205A/es active IP Right Grant
- 2008-06-06 EP EP08770406.0A patent/EP2164328B8/en not_active Not-in-force
-
2009
- 2009-11-23 IL IL202286A patent/IL202286A0/en unknown
-
2010
- 2010-11-29 US US12/955,792 patent/US8343957B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1142496A1 (en) | 2010-12-10 |
| US20080306048A1 (en) | 2008-12-11 |
| EP2164328B8 (en) | 2013-09-11 |
| AU2008261888A1 (en) | 2008-12-18 |
| CN101686682A (zh) | 2010-03-31 |
| US7863266B2 (en) | 2011-01-04 |
| US8343957B2 (en) | 2013-01-01 |
| EP2164328B1 (en) | 2013-08-07 |
| ES2433566T3 (es) | 2013-12-11 |
| US20110071140A1 (en) | 2011-03-24 |
| EP2164328A1 (en) | 2010-03-24 |
| IL202286A0 (en) | 2010-06-16 |
| BRPI0812347A2 (pt) | 2016-08-02 |
| KR20100038189A (ko) | 2010-04-13 |
| WO2008154442A1 (en) | 2008-12-18 |
| EP2164328A4 (en) | 2010-06-23 |
| JP2010529144A (ja) | 2010-08-26 |
| CA2688405A1 (en) | 2008-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |