MX2009012597A - Poxvirus de mapache que expresa glicoproteinas de la rabia. - Google Patents

Poxvirus de mapache que expresa glicoproteinas de la rabia.

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Publication number
MX2009012597A
MX2009012597A MX2009012597A MX2009012597A MX2009012597A MX 2009012597 A MX2009012597 A MX 2009012597A MX 2009012597 A MX2009012597 A MX 2009012597A MX 2009012597 A MX2009012597 A MX 2009012597A MX 2009012597 A MX2009012597 A MX 2009012597A
Authority
MX
Mexico
Prior art keywords
rabies
poxvirus
locus
poxvirus genome
hemagglutinin
Prior art date
Application number
MX2009012597A
Other languages
English (en)
Inventor
Michael A Gill
Hsien-Jue Chu
Stephen Qitu Wu
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MX2009012597A publication Critical patent/MX2009012597A/es

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/205—Rhabdoviridae, e.g. rabies virus
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/863—Poxviral vectors, e.g. entomopoxvirus
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Abstract

La presente invención se relaciona con los vectores poxvirus recombinantes de mapache que expresan el gen de la glicoproteína del virus de la rabia en el sitio hemaglutinina (ha) del genoma del poxvirus o expresan el gen de la glicoproteína de la misma o diferentes cepas de la rabia en el sitio timidina quinasa (tk) y el sitio hemaglutinina (ha) del genoma del poxvirus, y su uso como vacunas libres de adyuvante. El vector del poxvirus de mapache comprende las moléculas de ácido nucleico que codifican la glicoproteína de una cepa de la rabia "Challenge Virus Standard" insertada y expresada en el sitio tk del genoma del poxvirus y de una cepa de la rabia Pasteur-Paris insertada y expresada en el sitio ha del genoma del poxvirus. La vacuna puede opcionalmente contener una mezcla de antígenos de felino y canino adicionales para la inmunización de los animales. También se describen métodos para inducir una respuesta inmune contra la rabia en un mamífero mediante administrar al mamífero una cantidad efectiva inmunizante de la vacuna de la invención.
MX2009012597A 2007-05-30 2008-05-28 Poxvirus de mapache que expresa glicoproteinas de la rabia. MX2009012597A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93249207P 2007-05-30 2007-05-30
PCT/US2008/006736 WO2008153794A1 (en) 2007-05-30 2008-05-28 Raccoon poxvirus expressing rabies glycoproteins

Publications (1)

Publication Number Publication Date
MX2009012597A true MX2009012597A (es) 2009-12-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012597A MX2009012597A (es) 2007-05-30 2008-05-28 Poxvirus de mapache que expresa glicoproteinas de la rabia.

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Country Link
US (1) US8795681B2 (es)
EP (2) EP2150624B1 (es)
JP (1) JP5653751B2 (es)
KR (1) KR20100031523A (es)
CN (1) CN101680036B (es)
AR (1) AR066813A1 (es)
AU (1) AU2008263208B8 (es)
BR (1) BRPI0813313A8 (es)
CA (1) CA2681454C (es)
CL (1) CL2008001543A1 (es)
CO (1) CO6140071A2 (es)
HK (1) HK1142370A1 (es)
MX (1) MX2009012597A (es)
NZ (1) NZ597773A (es)
PH (1) PH12013501116A1 (es)
TW (1) TW200907058A (es)
WO (1) WO2008153794A1 (es)
ZA (1) ZA200908390B (es)

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CN116621949B (zh) * 2023-04-25 2024-01-30 华南生物医药研究院 一种增加狂犬病毒g蛋白分泌表达的方法及应用
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AU2008263208A1 (en) 2008-12-18
CN101680036A (zh) 2010-03-24
CA2681454C (en) 2018-01-30
NZ597773A (en) 2013-05-31
AU2008263208B8 (en) 2012-08-16
EP2540314A1 (en) 2013-01-02
BRPI0813313A8 (pt) 2016-04-19
AR066813A1 (es) 2009-09-16
EP2150624A1 (en) 2010-02-10
EP2150624B1 (en) 2015-07-08
ZA200908390B (en) 2010-08-25
WO2008153794A1 (en) 2008-12-18
JP2010528605A (ja) 2010-08-26
CA2681454A1 (en) 2008-12-18
KR20100031523A (ko) 2010-03-22
HK1142370A1 (en) 2010-12-03
BRPI0813313A2 (pt) 2014-12-23
CO6140071A2 (es) 2010-03-19
TW200907058A (en) 2009-02-16
US8795681B2 (en) 2014-08-05
US20090010963A1 (en) 2009-01-08
CN101680036B (zh) 2014-03-05
CL2008001543A1 (es) 2008-07-25
AU2008263208B2 (en) 2012-04-19
PH12013501116A1 (en) 2016-02-01
EP2150624A4 (en) 2010-10-13
JP5653751B2 (ja) 2015-01-14

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