CO6140071A2 - Poxvirus de mapache que expresa glicoproteinas de la rabia - Google Patents

Poxvirus de mapache que expresa glicoproteinas de la rabia

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Publication number
CO6140071A2
CO6140071A2 CO09133041A CO09133041A CO6140071A2 CO 6140071 A2 CO6140071 A2 CO 6140071A2 CO 09133041 A CO09133041 A CO 09133041A CO 09133041 A CO09133041 A CO 09133041A CO 6140071 A2 CO6140071 A2 CO 6140071A2
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CO
Colombia
Prior art keywords
site
rabies
nucleic acid
acid molecules
raccoon
Prior art date
Application number
CO09133041A
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English (en)
Inventor
Stephen Wu
Michael A Gill
Hsien-Jue Chu
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Wyeth Corp
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Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO6140071A2 publication Critical patent/CO6140071A2/es

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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/863—Poxviral vectors, e.g. entomopoxvirus
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Abstract

La presente invención se relaciona con los vectores poxvirus recombinantes de mapache que expresan el gen de la glicoproteína del virus de la rabia en el sitio hemaglutinina (ha) del genoma del poxvirus o expresan el gen de la glicoproteína de la misma o diferentes cepas de la rabia en el sitio timidina quinasa (tk) y el sitio hemaglutinina (ha) del genoma del poxvirus, y su uso como vacunas libres de adyuvante. El vector del poxvirus de mapache comprende las moléculas de ácido nucleico que codifican la glicoproteína de una cepa de la rabia "Challenge Virus Standard" insertada y expresada en el sitio tk del genoma del poxvirus y de una cepa de la rabia Pasteur-Paris insertada y expresada en el sitio ha del genoma del poxvirus. La vacuna puede opcionalmente contener una mezcla de antígenos de felino y canino adicionales para la inmunización de los animales. También se describen métodos para inducir una respuesta inmune contra la rabia en un mamífero mediante administrar al mamífero una cantidad efectiva inmunizante de la vacuna de la invención. 1.- Un vector poxvirus recombinante de mapache (rRCNV) comprende dos o más moléculas de ácido nucleico exógenas, cada una codifica por lo menos una glicoproteína del virus de la rabia, en donde por lo menos dos de las moléculas de ácido nucleico se insertan dentro del sitio de hemaglutinina (ha) o el sitio de timidina guinasa (tk), o por lo menos una de las moléculas de ácido nucleico se inserta en cada uno de los sitios de hemaglutinina y timidina quinasa.2.- El vector poxvirus recombinante de mapache de acuerdo con la reivindicación 1, en donde dichas dos moléculas de ácido nucleico codifican una glicoproteína el virus de la rabia se aíslan de la misma cepa del virus de la rabia.3.- El vector poxvirus recombinante de mapache de acuerdo con la reivindicación 1, en donde dichas dos moléculas del ácido nucleico codifican una glicoproteína del virus de la rabia se aíslan de una cepa diferente del virus de la rabia.
CO09133041A 2007-05-30 2009-11-23 Poxvirus de mapache que expresa glicoproteinas de la rabia CO6140071A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93249207P 2007-05-30 2007-05-30

Publications (1)

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CO6140071A2 true CO6140071A2 (es) 2010-03-19

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CO09133041A CO6140071A2 (es) 2007-05-30 2009-11-23 Poxvirus de mapache que expresa glicoproteinas de la rabia

Country Status (18)

Country Link
US (1) US8795681B2 (es)
EP (2) EP2150624B1 (es)
JP (1) JP5653751B2 (es)
KR (1) KR20100031523A (es)
CN (1) CN101680036B (es)
AR (1) AR066813A1 (es)
AU (1) AU2008263208B8 (es)
BR (1) BRPI0813313A8 (es)
CA (1) CA2681454C (es)
CL (1) CL2008001543A1 (es)
CO (1) CO6140071A2 (es)
HK (1) HK1142370A1 (es)
MX (1) MX2009012597A (es)
NZ (1) NZ597773A (es)
PH (1) PH12013501116A1 (es)
TW (1) TW200907058A (es)
WO (1) WO2008153794A1 (es)
ZA (1) ZA200908390B (es)

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KR102712874B1 (ko) * 2021-07-02 2024-10-04 주식회사 바이오에프디엔씨 고주파 특이적 발현 프로모터
CN116621949B (zh) * 2023-04-25 2024-01-30 华南生物医药研究院 一种增加狂犬病毒g蛋白分泌表达的方法及应用
CN116656730B (zh) * 2023-05-25 2024-03-19 军事科学院军事医学研究院军事兽医研究所 一种表达狂犬病病毒g、m蛋白的重组金丝雀痘病毒及其构建方法

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BRPI0813313A8 (pt) 2016-04-19
AR066813A1 (es) 2009-09-16
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