MX2009010407A - Derivados fluorados de deferiprona. - Google Patents

Derivados fluorados de deferiprona.

Info

Publication number
MX2009010407A
MX2009010407A MX2009010407A MX2009010407A MX2009010407A MX 2009010407 A MX2009010407 A MX 2009010407A MX 2009010407 A MX2009010407 A MX 2009010407A MX 2009010407 A MX2009010407 A MX 2009010407A MX 2009010407 A MX2009010407 A MX 2009010407A
Authority
MX
Mexico
Prior art keywords
deferiprone
fluorinated derivatives
iron
relates
present
Prior art date
Application number
MX2009010407A
Other languages
English (en)
Inventor
Tim Fat Tam
Yingsheng Wang
Regis Leung-Toug
Yanquing Zhao
Original Assignee
Apotex Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Technologies Inc filed Critical Apotex Technologies Inc
Publication of MX2009010407A publication Critical patent/MX2009010407A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se relaciona con derivados novedosos de deferiprona. En particular, la presente invención se relaciona con derivados fluorados de deferiprona o sales farmacéuticamente aceptables de las mismas, las composiciones farmacéuticas que comprenden los mismos, procesos para la fabricación de estos y su uso en el tratamiento de enfermedades neurodegenerativas causadas por la presencia de hierro libre o acumulación de hierro en el tejido neural y en enfermedades en donde el hierro exceso debe ser removido o redistribuido.
MX2009010407A 2007-03-28 2008-03-27 Derivados fluorados de deferiprona. MX2009010407A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90729007P 2007-03-28 2007-03-28
PCT/CA2008/000558 WO2008116301A1 (en) 2007-03-28 2008-03-27 Fluorinated derivatives of deferiprone

Publications (1)

Publication Number Publication Date
MX2009010407A true MX2009010407A (es) 2009-12-01

Family

ID=39743019

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009010407A MX2009010407A (es) 2007-03-28 2008-03-27 Derivados fluorados de deferiprona.

Country Status (15)

Country Link
US (2) US8026261B2 (es)
EP (1) EP2134688B1 (es)
CN (2) CN101679263B (es)
AR (1) AR065880A1 (es)
AU (1) AU2008232262B2 (es)
CA (2) CA2627529A1 (es)
CL (1) CL2008000887A1 (es)
IL (1) IL201189A (es)
MX (1) MX2009010407A (es)
NZ (2) NZ579928A (es)
PE (1) PE20081596A1 (es)
TW (1) TWI404533B (es)
UY (1) UY30986A1 (es)
WO (1) WO2008116301A1 (es)
ZA (1) ZA200906712B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ579928A (en) 2007-03-28 2012-09-28 Apotex Technologies Inc Fluorinated derivatives of deferiprone
GB0803019D0 (en) * 2008-02-19 2008-03-26 Btg Int Ltd Fluorinated compounds
AU2008355464C1 (en) 2008-04-25 2014-11-20 Chiesi Farmaceutici S.P.A. Liquid formulation for deferiprone with palatable taste
KR101682966B1 (ko) 2009-07-03 2016-12-06 아포텍스 테크놀로지스 인크. 3―하이드록시피리딘―4―온의 불소화된 유도체
SG190007A1 (en) 2010-11-29 2013-06-28 Pfizer Monobactams
GB201111704D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Novel compounds
GB201111705D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Compounds and their use
CN102861017A (zh) * 2011-07-08 2013-01-09 辽宁省计划生育科学研究院 一种化合物在防治老年痴呆的应用
JO3115B1 (ar) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
US9212147B2 (en) 2011-11-15 2015-12-15 Takeda Pharmaceutical Company Limited Dihydroxy aromatic heterocyclic compound
GB201222711D0 (en) 2012-12-17 2013-01-30 Takeda Pharmaceutical Novel compounds
EP3016935B1 (en) * 2013-07-04 2018-09-05 Hetero Research Foundation Process for the preparation of intermediate of dolutegravir
US10802459B2 (en) 2015-04-27 2020-10-13 Ademco Inc. Geo-fencing with advanced intelligent recovery
US10516965B2 (en) 2015-11-11 2019-12-24 Ademco Inc. HVAC control using geofencing
US10605472B2 (en) 2016-02-19 2020-03-31 Ademco Inc. Multiple adaptive geo-fences for a building
WO2017152237A1 (en) * 2016-03-10 2017-09-14 The University Of Sydney Novel analogues of desferrioxamine b (dfob)
CN111170936B (zh) * 2020-01-19 2021-01-01 杭州泽德医药科技有限公司 3,4-二羟基-n-(1’-苄基-2’-羟乙基)-2-甲基吡啶氯化物及制备和应用

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2918402A (en) * 1958-07-29 1959-12-22 Dodge Chem Co Bactericidal-fungicidal compositions
BE639493A (es) 1962-12-20
CA1095921A (en) * 1976-08-02 1981-02-17 Thomas M. Brennan Preparation of gamma-pyrones
GB8308054D0 (en) 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
GB8308055D0 (en) 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
USRE34313E (en) 1983-09-23 1993-07-13 National Research Development Corporation Pharmaceutical compositions
GB8325496D0 (en) 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
GB8329043D0 (en) * 1983-10-31 1983-11-30 Hider R C Pharmaceutical compositions
JPH01305081A (ja) 1988-04-04 1989-12-08 E R Squibb & Sons Inc ３―アシルアミノ―１―［［［（置換スルホニル）アミノ〕カルボニル〕アミノ〕―２―アゼチジノン類
DE3826846A1 (de) * 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
JPH0714872B2 (ja) 1990-02-06 1995-02-22 昭和薬品化工株式会社 シロップ剤組成物
GB9100465D0 (en) * 1991-01-09 1991-02-20 Hider Robert C Pharmaceutical compositions
US5624807A (en) 1992-07-22 1997-04-29 The Mclean Hospital Corporation Methods for detecting Alzheimer's disease by measuring ratios of calcium-activated neutral protease isoforms
CA2121435C (en) 1993-04-16 2002-01-22 Sheila M. Ratnaraj Aqueous pharmaceutical suspension and process for preparation thereof
CA2181463A1 (en) * 1994-01-31 1995-08-03 Fu-Ning Fung Method of synthesizing gamma pyrones
WO1995027485A1 (en) 1994-04-08 1995-10-19 The Procter & Gamble Company Methods of using iron chelating compounds to reduce free radical damage in mammals
CA2172807C (en) 1994-08-01 1999-10-12 Keith S. Lienhop Tastemasked liquid pharmaceutical delivery system
US5616621A (en) 1995-01-30 1997-04-01 American Home Products Corporation Taste masking liquids
JPH0925234A (ja) * 1995-07-12 1997-01-28 Wakunaga Pharmaceut Co Ltd 脳疾患改善剤
US5763449A (en) 1996-08-07 1998-06-09 Ascent Pediatrics, Inc. Pleasant-tasting aqueous liquid composition of a bitter-tasting drug
GB9711093D0 (en) * 1997-05-29 1997-07-23 British Tech Group Novel orally active iron (III) chelators
WO2000012135A1 (en) 1998-08-28 2000-03-09 Eisai Co., Ltd Medicinal compositions with relieved bitterness, etc.
US6472378B2 (en) 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US6133322A (en) 1998-10-29 2000-10-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) Quinone derivatives for treating or preventing diseases associated with iron overload
US6933104B1 (en) 1999-04-23 2005-08-23 Shiva Biomedical, Llc Diagnosis and treatment of human kidney diseases
IL130324A0 (en) 1999-06-07 2000-06-01 Yeda Res & Dev Pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders and some novel iron chelators
AUPQ262499A0 (en) 1999-09-02 1999-09-23 University Of Queensland, The Novel iron chelators
CA2313270C (en) 2000-06-30 2011-09-13 Apotex Inc. Use of deferiprone in treating and preventing iron-induced cardiac disease
CA2440412A1 (en) 2001-03-05 2002-09-19 Ortho-Mcneil Pharmaceutical, Inc. Taste masked liquid pharmaceutical compositions
WO2003075910A1 (en) 2002-03-08 2003-09-18 Protemix Corporation Limited Preventing and/or treating vascular disease, cardiomyopathy and/or associated heart failure
NZ534746A (en) 2002-03-12 2006-06-30 Bristol Myers Squibb Co Palatable oral suspension and method
AU2003251920A1 (en) 2002-07-12 2004-02-02 The Buck Institute For Research On Aging Iron sequestration or elimination to reduce neurodegeneration or parkinsons disease progression
EP1565185A4 (en) 2002-11-07 2011-01-05 Technion Res & Dev Foundation NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS THEREWITH
DE10336497B4 (de) * 2003-08-08 2007-04-05 Freie Universität Berlin Substituierte Pyridine und ein Verfahren zur Herstellung von substituierten Pyridinen
EP1742535A4 (en) 2004-05-06 2008-10-15 Cydex Pharmaceuticals Inc MASTER TASTE PREPARATIONS CONTAINING SERTRALINE AND SULFOALKYLETHER CYCLODEXTRIN
US9737511B2 (en) 2004-05-24 2017-08-22 Geoffrey C. GURTNER Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
CA2568134A1 (en) 2004-05-24 2005-12-08 New York University Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
US7728038B2 (en) 2004-08-04 2010-06-01 University Of Utah Research Foundation Methods for chelation therapy
JP2006150061A (ja) 2004-11-04 2006-06-15 Nec Corp ドラッグデリバリシステム及びそれに用いる薬剤カプセル並びに送信機
US20070197469A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V Fluoroquinolone carboxylic acid salt compositions
MY151412A (en) 2006-02-22 2014-05-30 Munnich Arnold The use of deferiprone and methods to treat and/or prevent friedreich ataxia resulting from intracellular mishandling of iron
NZ579928A (en) 2007-03-28 2012-09-28 Apotex Technologies Inc Fluorinated derivatives of deferiprone
GB0803019D0 (en) 2008-02-19 2008-03-26 Btg Int Ltd Fluorinated compounds

Also Published As

Publication number Publication date
UY30986A1 (es) 2008-09-02
CN101679263A (zh) 2010-03-24
ZA200906712B (en) 2011-02-23
PE20081596A1 (es) 2009-02-05
CN101679263B (zh) 2014-01-15
TWI404533B (zh) 2013-08-11
CA2681545C (en) 2013-10-01
AU2008232262A1 (en) 2008-10-02
AU2008232262B2 (en) 2013-02-14
EP2134688B1 (en) 2016-10-05
CA2681545A1 (en) 2008-10-02
US8026261B2 (en) 2011-09-27
IL201189A (en) 2015-06-30
EP2134688A1 (en) 2009-12-23
AR065880A1 (es) 2009-07-08
WO2008116301A1 (en) 2008-10-02
CA2627529A1 (en) 2008-09-28
IL201189A0 (en) 2010-05-17
US8673943B2 (en) 2014-03-18
EP2134688A4 (en) 2011-01-19
US20080242706A1 (en) 2008-10-02
CN102964296A (zh) 2013-03-13
CN102964296B (zh) 2015-03-25
US20120095061A1 (en) 2012-04-19
TW200843760A (en) 2008-11-16
NZ600874A (en) 2013-01-25
NZ579928A (en) 2012-09-28
CL2008000887A1 (es) 2008-05-30

Similar Documents

Publication Publication Date Title
MX2009010407A (es) Derivados fluorados de deferiprona.
MX2009008531A (es) Cetonas de heterociclilo que contienen nitrogeno y su uso como inhibidores de c-met.
IN2012DN01233A (es)
MX2013011908A (es) Composiciones y usos terapeuticos de inhibidores de cinasa epsilon relacionados con cinasa i-kappa b (ikk) y cinasa 1 de union tank.
SG179120A1 (en) Novel compounds
WO2009127642A3 (en) Use of lrrk2 inhibitors for neurodegenerative diseases
PH12013502262A1 (en) Spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines as bace1 and/or bace2 inhibitors
TN2012000428A1 (en) Bisaryl-bonded aryltriazolones and use thereof
MY179527A (en) Catecholamine derivatives useful for the treatment of parkinson's disease
EA201171088A1 (ru) Лечение дискинезии при различных расстройствах
MX2015016425A (es) Derivados de pirazolo-pirrolidin-4-ona y su uso en el tratamiento de enfermedades.
PH12015502365B1 (en) Bace1 inhibitors
MX2010009624A (es) Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1 y cx3cr1.
WO2010121164A3 (en) 1,4-benzodiazepinone compounds and their use in treating cancer
PH12014502623B1 (en) Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as bace1 inhibitors
PH12014502541A1 (en) 5-amino [1,4] thiazines as bace 1 inhibitors
MX2013002118A (es) 2-oxi-quinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
MX2012007234A (es) Nanocristales de monohidrato de calciprotiol.
MX2013002956A (es) Arilsulfonamidas para el tratamiento de enfermedades del sistema nervioso central.
PH12015501402A1 (en) 4-hydroxy-2-methyl-5-(propan-2-ylidene)cyclohex-3-enecarbaldehyde for the prevention and treatment of a cognitive, neurodegenerative or neuronal disease
IN2012DN06061A (es)
MY182553A (en) Pharmaceutical compositions comprising 7-(1h-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions
MX2010004620A (es) Derivados de benzomorfolina y metodos de uso.
MX2012012410A (es) Agente terapeutico y agente preventivo para enfermedad de alzheimer.
WO2007017146A3 (en) Use of collismycin and derivatives thereof as oxidative stress inhibitors

Legal Events

Date Code Title Description
FG Grant or registration