MX2009009141A - Formas cristalinas de un compuesto de 8-azabiciclo[3,2,1]octano. - Google Patents
Formas cristalinas de un compuesto de 8-azabiciclo[3,2,1]octano.Info
- Publication number
- MX2009009141A MX2009009141A MX2009009141A MX2009009141A MX2009009141A MX 2009009141 A MX2009009141 A MX 2009009141A MX 2009009141 A MX2009009141 A MX 2009009141A MX 2009009141 A MX2009009141 A MX 2009009141A MX 2009009141 A MX2009009141 A MX 2009009141A
- Authority
- MX
- Mexico
- Prior art keywords
- azabicyclo
- crystalline forms
- crystalline
- salt forms
- octane compound
- Prior art date
Links
- -1 8-azabicyclo[3.2.1]octane compound Chemical class 0.000 title 1
- 150000003839 salts Chemical group 0.000 abstract 3
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000051367 mu Opioid Receptors Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract 1
- 108020001612 μ-opioid receptors Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90409007P | 2007-02-28 | 2007-02-28 | |
| PCT/US2008/002583 WO2008106159A1 (en) | 2007-02-28 | 2008-02-27 | Crystalline forms of an 8-azabicyclo[3.2.1]octane compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009009141A true MX2009009141A (es) | 2009-09-03 |
Family
ID=39620376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009009141A MX2009009141A (es) | 2007-02-28 | 2008-02-27 | Formas cristalinas de un compuesto de 8-azabiciclo[3,2,1]octano. |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US7943772B2 (enExample) |
| EP (1) | EP2132204B1 (enExample) |
| JP (2) | JP5512289B2 (enExample) |
| KR (1) | KR101480530B1 (enExample) |
| CN (1) | CN101616916B (enExample) |
| AR (2) | AR065554A1 (enExample) |
| AU (1) | AU2008219615B2 (enExample) |
| BR (1) | BRPI0807974B8 (enExample) |
| CA (1) | CA2678073C (enExample) |
| CL (1) | CL2008000573A1 (enExample) |
| CO (1) | CO6220856A2 (enExample) |
| CY (1) | CY1115077T1 (enExample) |
| DK (1) | DK2132204T3 (enExample) |
| ES (1) | ES2402031T3 (enExample) |
| HR (1) | HRP20130193T1 (enExample) |
| IL (1) | IL200131A (enExample) |
| MX (1) | MX2009009141A (enExample) |
| MY (1) | MY148318A (enExample) |
| NZ (1) | NZ578871A (enExample) |
| PL (1) | PL2132204T3 (enExample) |
| PT (1) | PT2132204E (enExample) |
| RU (1) | RU2458061C2 (enExample) |
| SI (1) | SI2132204T1 (enExample) |
| TW (1) | TWI409067B (enExample) |
| WO (1) | WO2008106159A1 (enExample) |
| ZA (1) | ZA200905832B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| TWI409067B (zh) * | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| TWI415850B (zh) * | 2007-07-20 | 2013-11-21 | Theravance Inc | 製備ｍｕ類鴉片受體拮抗劑之中間物的方法 |
| WO2009029253A1 (en) * | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| DE602008005771D1 (de) * | 2007-08-27 | 2011-05-05 | Theravance Inc | Disubstituierte alkyl-8-azabicycloä3.2.1üoktan-verbindungen als mu-opioid-rezeptorantagonisten |
| TWI423801B (zh) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| EP2185553B1 (en) * | 2007-08-27 | 2012-06-27 | Theravance, Inc. | Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| JP5797655B2 (ja) * | 2009-09-18 | 2015-10-21 | アドラー・コーポレーション | 消化管障害のためのオピオイド受容体アンタゴニストの使用 |
| HRP20200432T1 (hr) | 2015-04-02 | 2020-06-12 | Theravance Biopharma R&D Ip, Llc | Oblik za kombinacijsko doziranje antagonista mu opioidnog receptora i opioidnog sredstva |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| US6900228B1 (en) | 1998-03-10 | 2005-05-31 | Research Triangle Institute | Opiate compounds, methods of making and methods of use |
| GB9810671D0 (en) | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
| TWI244481B (en) | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB9912410D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| US6469030B2 (en) | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
| US6467084B1 (en) * | 1999-12-16 | 2002-10-15 | Emware, Inc. | Systems and methods for reprogramming an embedded device with program code using relocatable program code |
| US6552036B2 (en) | 2000-03-03 | 2003-04-22 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
| US20020025948A1 (en) | 2000-06-23 | 2002-02-28 | Banks Bernard Joseph | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| AP1816A (en) | 2001-10-22 | 2008-01-04 | Pfizer Prod Inc | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists. |
| US7381721B2 (en) | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
| US20040204453A1 (en) | 2003-04-14 | 2004-10-14 | Pfizer Inc | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors |
| MXPA05011070A (es) | 2003-04-14 | 2005-12-12 | Pfizer Prod Inc | Derivados de 3-azabiciclo [3.2.1] octano. |
| US7056930B2 (en) * | 2003-04-14 | 2006-06-06 | Pfizer Inc. | 2-Azabicyclo[3.3.1]nonane derivatives |
| JP2006523673A (ja) | 2003-04-15 | 2006-10-19 | ファイザー・プロダクツ・インク | オピオイド受容体活性を有する３−ベンズヒドリリデン−８−アザ−ビシクロ［３．２．１］オクタン誘導体 |
| US6992090B2 (en) | 2003-06-16 | 2006-01-31 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| EP1737853A1 (en) | 2004-02-03 | 2007-01-03 | Janssen Pharmaceutica N.V. | 3-(diheteroarylmethylene)-8-azabicyclo¬3.2.1|octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo¬3.2.1|octane derivatives |
| US7087749B2 (en) | 2004-03-11 | 2006-08-08 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| CN101534827A (zh) | 2006-11-07 | 2009-09-16 | 尼克塔治疗亚拉巴马公司 | 阿片样物质激动剂和阿片样物质拮抗剂的剂型和联合给药 |
| TWI409067B (zh) * | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
-
2008
- 2008-02-15 TW TW097105472A patent/TWI409067B/zh active
- 2008-02-25 CL CL200800573A patent/CL2008000573A1/es unknown
- 2008-02-27 CA CA2678073A patent/CA2678073C/en active Active
- 2008-02-27 MY MYPI20093401A patent/MY148318A/en unknown
- 2008-02-27 RU RU2009135834/04A patent/RU2458061C2/ru active
- 2008-02-27 DK DK08726162.4T patent/DK2132204T3/da active
- 2008-02-27 JP JP2009551709A patent/JP5512289B2/ja active Active
- 2008-02-27 BR BRPI0807974A patent/BRPI0807974B8/pt not_active IP Right Cessation
- 2008-02-27 PT PT87261624T patent/PT2132204E/pt unknown
- 2008-02-27 US US12/072,534 patent/US7943772B2/en active Active
- 2008-02-27 HR HRP20130193AT patent/HRP20130193T1/hr unknown
- 2008-02-27 MX MX2009009141A patent/MX2009009141A/es active IP Right Grant
- 2008-02-27 SI SI200830928T patent/SI2132204T1/sl unknown
- 2008-02-27 KR KR1020097020094A patent/KR101480530B1/ko active Active
- 2008-02-27 NZ NZ578871A patent/NZ578871A/en not_active IP Right Cessation
- 2008-02-27 PL PL08726162T patent/PL2132204T3/pl unknown
- 2008-02-27 CN CN2008800059690A patent/CN101616916B/zh active Active
- 2008-02-27 EP EP08726162A patent/EP2132204B1/en active Active
- 2008-02-27 WO PCT/US2008/002583 patent/WO2008106159A1/en not_active Ceased
- 2008-02-27 AU AU2008219615A patent/AU2008219615B2/en not_active Ceased
- 2008-02-27 ES ES08726162T patent/ES2402031T3/es active Active
- 2008-02-28 AR ARP080100850A patent/AR065554A1/es not_active Application Discontinuation
-
2009
- 2009-07-29 IL IL200131A patent/IL200131A/en active IP Right Grant
- 2009-08-21 ZA ZA200905832A patent/ZA200905832B/xx unknown
- 2009-08-26 CO CO09089674A patent/CO6220856A2/es active IP Right Grant
-
2011
- 2011-04-06 US US13/081,162 patent/US8247555B2/en active Active
-
2012
- 2012-07-17 US US13/550,781 patent/US8536335B2/en active Active
-
2013
- 2013-04-08 CY CY20131100293T patent/CY1115077T1/el unknown
- 2013-05-10 JP JP2013099851A patent/JP2013151564A/ja not_active Withdrawn
- 2013-08-13 US US13/965,691 patent/US8816091B2/en active Active
-
2014
- 2014-07-16 US US14/333,003 patent/US9290491B2/en active Active
-
2016
- 2016-02-10 US US15/040,191 patent/US9949963B2/en active Active
-
2017
- 2017-07-31 AR ARP170102183A patent/AR109224A2/es unknown
-
2018
- 2018-03-13 US US15/919,678 patent/US10426766B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2009009141A (es) | Formas cristalinas de un compuesto de 8-azabiciclo[3,2,1]octano. | |
| TW200800981A (en) | 8-azabicyclo[3.2.1]octane compounds as MU opioid receptor antagonists | |
| MX2010002171A (es) | Compuestos 8-azabiciclo[3.2.1] octil-2 hidroxibenzamida como antagonistas de los receptores opioides mu. | |
| ATE502939T1 (de) | Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten | |
| TW200643020A (en) | Crystalline form of a quinolinone-carboxamide compound | |
| IL195891A0 (en) | Derivatives of imidazo[1,2-a]pyridine-2-carboxamides, preparation method thereof and use od same in therapeutics | |
| MXPA05012678A (es) | Forma cristalina del agonista del receptor adrenergico beta2. | |
| MX2009006018A (es) | Derivados de quinuclidinol como antagonistas de receptores muscarinicos. | |
| WO2007098826A3 (en) | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof | |
| HK1197240A1 (en) | New cyclohexylamine derivatives having beta 2 adrenergic agonist and m3 muscarinic antagonist activities | |
| MY139720A (en) | Micronized crystalline tiotropium bromide | |
| IL195818A0 (en) | Derivatives of 2-benzoyl-imidazopyridines, preparation ,method thereof and use of same in therapeutics | |
| BRPI0821611A8 (pt) | Derivado de 3-carboxipropil-aminotetralina e compostos relacionados como antagonistas do receptor opióide mu | |
| MX2010000813A (es) | Proceso para preparar un intermediario para los antagonistas de los receptores opioides mu. | |
| PL1869038T3 (pl) | Podstawione pochodne 5,6,7,8-tetrahydro-imidazo[1,2-a]pirydyn-2-yloaminy i ich zastosowanie do wytwarzania środków leczniczych | |
| TW200640921A (en) | Crystalline form of an indazole-carboxamide compound | |
| EP4616915A3 (en) | Ecopipam for treatment of tourettes syndrome | |
| MY179041A (en) | Crystalline forms of a 3-carboxypropyl-aminotetralin compound | |
| IL192864A0 (en) | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof | |
| ZA200807467B (en) | 8-Azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists | |
| TH120971A (th) | รูปแบบเชิงผลึกของสารประกอบ 8-อะซาไบไซโคล[3.2.1]ออกเทน | |
| WO2009010492A3 (en) | Combinations comprising telmisartan and an anticholinergic such as tiotropium or a glycopyrronium salt for the treatment of respiratory diseases such as copd or asthma | |
| HK1161220A (en) | Crystalline forms of a 3-carboxypropyl-aminotetralin compound |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HH | Correction or change in general | ||
| FG | Grant or registration |