MX2009006751A - Sphingosine-1 -phosphate receptor agonist and antagonist compounds. - Google Patents

Sphingosine-1 -phosphate receptor agonist and antagonist compounds.

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Publication number
MX2009006751A
MX2009006751A MX2009006751A MX2009006751A MX2009006751A MX 2009006751 A MX2009006751 A MX 2009006751A MX 2009006751 A MX2009006751 A MX 2009006751A MX 2009006751 A MX2009006751 A MX 2009006751A MX 2009006751 A MX2009006751 A MX 2009006751A
Authority
MX
Mexico
Prior art keywords
sphingosine
receptor agonist
antagonist compounds
phosphate receptor
receptor family
Prior art date
Application number
MX2009006751A
Other languages
Spanish (es)
Inventor
Shannon R Fix-Stenzel
Thomas D Gordon
Grier A Wallace
Pintipa Grongsaard
Kevin P Cusack
Adrian D Hobson
Eric C Breinlinger
Graham K Ansell
Martin E Hayes
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39562856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009006751(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2009006751A publication Critical patent/MX2009006751A/en

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    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
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Abstract

The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.
MX2009006751A 2006-12-21 2007-12-21 Sphingosine-1 -phosphate receptor agonist and antagonist compounds. MX2009006751A (en)

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PCT/US2007/026263 WO2008079382A1 (en) 2006-12-21 2007-12-21 Sphingosine-1 -phosphate receptor agonist and antagonist compounds

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Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080086546A (en) * 2006-01-27 2008-09-25 유니버시티 오브 버지니아 페이턴트 파운데이션 Method for treatment of neuropathic pain
WO2007092638A1 (en) 2006-02-09 2007-08-16 University Of Virginia Patent Foundation Bicyclic sphingosine 1-phosphate analogs
WO2008064337A2 (en) 2006-11-21 2008-05-29 University Of Virginia Patent Foundation Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity
AU2007323540A1 (en) 2006-11-21 2008-05-29 University Of Virginia Patent Foundation Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity
JP2010513531A (en) * 2006-12-21 2010-04-30 アボット・ラボラトリーズ Process for the preparation and isolation of individual stereoisomers of 1-amino, 3-substituted phenylcyclopentanecarboxylic esters
JP5420534B2 (en) 2007-05-31 2014-02-19 サノビオン ファーマシューティカルズ インク Phenyl-substituted cycloalkylamines as monoamine reuptake inhibitors
HUE030424T2 (en) 2008-07-23 2017-05-29 Arena Pharm Inc SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
ES2583630T3 (en) 2008-08-27 2016-09-21 Arena Pharmaceuticals, Inc. Derivatives of substituted tricyclic acid as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
CA2740484C (en) 2008-10-17 2021-09-21 Akaal Pharma Pty Ltd S1p receptors modulators and their use thereof
WO2010042998A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
AR074061A1 (en) * 2008-10-31 2010-12-22 Lexicon Pharmaceuticals Inc S1P LIASA INHIBITORS FOR THE TREATMENT OF CEREBRAL MALARIA AND PHARMACEUTICAL FORMULATION
AR074062A1 (en) * 2008-10-31 2010-12-22 Lexicon Pharmaceuticals Inc S1P RECEIVER AGONISTS FOR THE TREATMENT OF BRAIN MALARIA AND PHARMACEUTICAL FORM
WO2010085581A1 (en) 2009-01-23 2010-07-29 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
EP2389377B1 (en) 2009-01-23 2014-07-16 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
JP2012515789A (en) 2009-01-23 2012-07-12 ブリストル−マイヤーズ スクイブ カンパニー Pyrazole-1,2,4-oxadiazole derivatives as sphingosine-1-phosphate agonists
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
CN103221391B (en) 2010-01-27 2018-07-06 艾尼纳制药公司 (R) preparation method of -2- (7- (4- cyclopenta -3- (trifluoromethyl) benzyls oxygroup) -1,2,3,4- tetrahydro cyclopentyl diene simultaneouslies [b] indol-3-yl) acetic acid and its salt
JP2013521301A (en) 2010-03-03 2013-06-10 アリーナ ファーマシューティカルズ， インコーポレイテッド Process for the preparation of S1P1 receptor modulators and their crystalline forms
EP2560969B1 (en) 2010-04-23 2015-08-12 Bristol-Myers Squibb Company 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists
TWI522361B (en) 2010-07-09 2016-02-21 艾伯維公司 Fused heterocyclic derivatives as s1p modulators
TW201206893A (en) 2010-07-09 2012-02-16 Abbott Healthcare Products Bv Bisaryl (thio) morpholine derivatives as S1P modulators
TWI543984B (en) * 2010-07-09 2016-08-01 艾伯維公司 Spiro-piperidine derivatives as s1p modulators
US9187437B2 (en) 2010-09-24 2015-11-17 Bristol-Myers Squibb Company Substituted oxadiazole compounds
AR085749A1 (en) 2011-04-01 2013-10-23 Novartis Ag FORMULATIONS
TWI613182B (en) * 2013-02-21 2018-02-01 必治妥美雅史谷比公司 Bicyclic compounds
JP6617702B2 (en) * 2013-07-15 2019-12-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア FTY720 azacyclic constraint analog
TW201613864A (en) 2014-02-20 2016-04-16 Takeda Pharmaceutical Novel compounds
MA40082B1 (en) * 2014-08-20 2019-09-30 Bristol Myers Squibb Co New Sphingosine Phosphate Substitution Compound Useful Treatment Disease Rheumatism
CN107405332A (en) 2015-01-06 2017-11-28 艾尼纳制药公司 Treatment and S1P1The method of receptor related illness
US10301262B2 (en) 2015-06-22 2019-05-28 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders
EP3352753A4 (en) * 2015-09-24 2019-03-13 The Regents of The University of California Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment
JP7029445B2 (en) * 2016-09-02 2022-03-03 ブリストル－マイヤーズ スクイブ カンパニー Substituted tricyclic heterocyclic compound
EP3582772A1 (en) 2017-02-16 2019-12-25 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
MA47503A (en) 2017-02-16 2021-04-21 Arena Pharm Inc COMPOUNDS AND METHODS FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES OF THE INTESTINE WITH EXTRAINTESTINAL MANIFESTATIONS
KR101891051B1 (en) * 2018-01-29 2018-08-31 주식회사 세종바이오메드 Sphingosine-1-Phosphate analogue and synthetic method thereof
EP3847158A1 (en) 2018-09-06 2021-07-14 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN110808093A (en) * 2019-09-16 2020-02-18 中山大学孙逸仙纪念医院 Prediction model for clinical prognosis of radioactive encephalopathy and construction method thereof
CN114728982A (en) 2019-10-31 2022-07-08 逃逸生物有限公司 Solid forms of S1P-receptor modulators
CN117007818B (en) * 2023-08-04 2024-04-09 徐州医科大学科技园发展有限公司 Application of S1PR1 as target in developing or preparing medicine for preventing chronic pain related memory injury diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2120351A1 (en) * 1991-10-02 1993-04-15 Siegfried B. Christensen, Iv Cyclopentane and cyclopentene derivatives with antiallergic antiinflammatory and tumor necrosis factor inhibiting activity
US5314896A (en) * 1991-11-20 1994-05-24 Warner-Lambert Company 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
AU2006214314B2 (en) * 2005-02-14 2012-02-09 University Of Virginia Patent Foundation Sphingosine 1- phos phate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups
JP2009527501A (en) * 2006-02-21 2009-07-30 ユニバーシティ オブ バージニア パテント ファンデーション Phenyl-cycloalkyl derivatives and phenyl-heterocyclic derivatives as S1P receptor agonists

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