CR10872A - AGONIST AND ANTAGONIST COMPOUNDS OF THE SPHINGOSINE-1-PHOSPHATE RECEPTOR - Google Patents
AGONIST AND ANTAGONIST COMPOUNDS OF THE SPHINGOSINE-1-PHOSPHATE RECEPTORInfo
- Publication number
- CR10872A CR10872A CR10872A CR10872A CR10872A CR 10872 A CR10872 A CR 10872A CR 10872 A CR10872 A CR 10872A CR 10872 A CR10872 A CR 10872A CR 10872 A CR10872 A CR 10872A
- Authority
- CR
- Costa Rica
- Prior art keywords
- sphingosine
- agonist
- antagonist compounds
- phosphate receptor
- receptor family
- Prior art date
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/38—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
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- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
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- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
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- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
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- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
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- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Abstract
La presente invencion se refiere a agentes novedosos, potentes y selectivos que son agonistas o antagonistas de los uno o mas receptores individuales de la familia de receptores S1P. Los compuestos de la invencion son utiles como agentes terapeuticos para el tratamiento de trastornos clinicos asociados con el agonismo o antagonismo de receptores individuales de la familia de receptore S1P.The present invention relates to novel, potent and selective agents that are agonists or antagonists of the one or more individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutic agents for the treatment of clinical disorders associated with agonism or antagonism of individual receptors of the S1P receptor family.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US87628806P | 2006-12-21 | 2006-12-21 | |
US87631806P | 2006-12-21 | 2006-12-21 |
Publications (1)
Publication Number | Publication Date |
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CR10872A true CR10872A (en) | 2009-07-23 |
Family
ID=39562856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CR10872A CR10872A (en) | 2006-12-21 | 2009-06-19 | AGONIST AND ANTAGONIST COMPOUNDS OF THE SPHINGOSINE-1-PHOSPHATE RECEPTOR |
Country Status (19)
Country | Link |
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EP (1) | EP2120575A4 (en) |
JP (1) | JP2010513532A (en) |
KR (1) | KR20090095659A (en) |
AR (1) | AR064650A1 (en) |
AU (1) | AU2007338700A1 (en) |
BR (1) | BRPI0720478A2 (en) |
CA (1) | CA2672727A1 (en) |
CL (1) | CL2007003784A1 (en) |
CO (1) | CO6180436A2 (en) |
CR (1) | CR10872A (en) |
DO (1) | DOP2009000149A (en) |
EC (1) | ECSP099435A (en) |
MX (1) | MX2009006751A (en) |
NO (1) | NO20092376L (en) |
PE (1) | PE20081561A1 (en) |
RU (1) | RU2009128062A (en) |
TW (1) | TW200838497A (en) |
UY (1) | UY30829A1 (en) |
WO (1) | WO2008079382A1 (en) |
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JP5420534B2 (en) * | 2007-05-31 | 2014-02-19 | サノビオン ファーマシューティカルズ インク | Phenyl-substituted cycloalkylamines as monoamine reuptake inhibitors |
KR20190004843A (en) | 2008-07-23 | 2019-01-14 | 아레나 파마슈티칼스, 인크. | SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS |
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JP2012515787A (en) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | Substituted oxadiazole derivatives as S1P agonists in the treatment of autoimmune and inflammatory diseases |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
EP4148045A1 (en) | 2010-01-27 | 2023-03-15 | Arena Pharmaceuticals, Inc. | Intermediate compounds for the preparation of (r)-2-(7-(4-cyclopentyl-3- (trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl)acetic acid and salts thereof |
CA2789480A1 (en) | 2010-03-03 | 2011-09-09 | Arena Pharmaceuticals, Inc. | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
EP2560969B1 (en) | 2010-04-23 | 2015-08-12 | Bristol-Myers Squibb Company | 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists |
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TWI522361B (en) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | Fused heterocyclic derivatives as s1p modulators |
TW201206893A (en) | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
ES2548258T3 (en) | 2010-09-24 | 2015-10-15 | Bristol-Myers Squibb Company | Oxadiazole compounds substituted and their use as S1P1 agonists |
AR085749A1 (en) | 2011-04-01 | 2013-10-23 | Novartis Ag | FORMULATIONS |
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EP3022176B8 (en) * | 2013-07-15 | 2019-12-25 | The Regents of the University of California | Azacyclic constrained analogs of fty720 |
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CA2999177A1 (en) | 2015-09-24 | 2017-03-30 | The Regents Of The University Of California | Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment |
JP7029445B2 (en) * | 2016-09-02 | 2022-03-03 | ブリストル-マイヤーズ スクイブ カンパニー | Substituted tricyclic heterocyclic compound |
CN110545848A (en) | 2017-02-16 | 2019-12-06 | 艾尼纳制药公司 | Compounds and methods for treating inflammatory bowel disease with extra-intestinal manifestations |
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WO1993007111A1 (en) * | 1991-10-02 | 1993-04-15 | Smithkline Beecham Corporation | Cyclopentane and cyclopentene derivatives with antiallergic antiinflammatory and tumor necrosis factor inhibiting activity |
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RU2008137553A (en) * | 2006-02-21 | 2010-03-27 | Юниверсити Оф Вирджиния Пэтент Фаундейшн (Us) | Phenyl Cycloalkyl Compounds Containing Heterocyclic Structures |
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2007
- 2007-12-21 CA CA002672727A patent/CA2672727A1/en not_active Abandoned
- 2007-12-21 TW TW096149594A patent/TW200838497A/en unknown
- 2007-12-21 CL CL200703784A patent/CL2007003784A1/en unknown
- 2007-12-21 JP JP2009542960A patent/JP2010513532A/en not_active Withdrawn
- 2007-12-21 EP EP07863237A patent/EP2120575A4/en not_active Withdrawn
- 2007-12-21 WO PCT/US2007/026263 patent/WO2008079382A1/en active Search and Examination
- 2007-12-21 UY UY30829A patent/UY30829A1/en not_active Application Discontinuation
- 2007-12-21 BR BRPI0720478-7A patent/BRPI0720478A2/en not_active Application Discontinuation
- 2007-12-21 MX MX2009006751A patent/MX2009006751A/en not_active Application Discontinuation
- 2007-12-21 RU RU2009128062/04A patent/RU2009128062A/en not_active Application Discontinuation
- 2007-12-21 AR ARP070105818A patent/AR064650A1/en not_active Application Discontinuation
- 2007-12-21 KR KR1020097015385A patent/KR20090095659A/en not_active Application Discontinuation
- 2007-12-21 AU AU2007338700A patent/AU2007338700A1/en not_active Abandoned
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2008
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- 2009-06-19 DO DO2009000149A patent/DOP2009000149A/en unknown
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- 2009-06-22 NO NO20092376A patent/NO20092376L/en not_active Application Discontinuation
Also Published As
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CL2007003784A1 (en) | 2008-06-27 |
AR064650A1 (en) | 2009-04-15 |
ECSP099435A (en) | 2009-07-31 |
AU2007338700A1 (en) | 2008-07-03 |
WO2008079382A1 (en) | 2008-07-03 |
MX2009006751A (en) | 2009-06-30 |
DOP2009000149A (en) | 2010-05-15 |
RU2009128062A (en) | 2011-01-27 |
EP2120575A1 (en) | 2009-11-25 |
UY30829A1 (en) | 2008-07-31 |
NO20092376L (en) | 2009-06-22 |
CO6180436A2 (en) | 2010-07-19 |
BRPI0720478A2 (en) | 2014-01-14 |
EP2120575A4 (en) | 2011-04-27 |
TW200838497A (en) | 2008-10-01 |
KR20090095659A (en) | 2009-09-09 |
PE20081561A1 (en) | 2008-10-30 |
CA2672727A1 (en) | 2008-07-03 |
JP2010513532A (en) | 2010-04-30 |
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