CO6180436A2 - AGONIST COMPOUND AND ANTAGONISTS OF THE RECEPTOR SPHYNOSINE- 1- PHOSPHATE - Google Patents

AGONIST COMPOUND AND ANTAGONISTS OF THE RECEPTOR SPHYNOSINE- 1- PHOSPHATE

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Publication number
CO6180436A2
CO6180436A2 CO09056803A CO09056803A CO6180436A2 CO 6180436 A2 CO6180436 A2 CO 6180436A2 CO 09056803 A CO09056803 A CO 09056803A CO 09056803 A CO09056803 A CO 09056803A CO 6180436 A2 CO6180436 A2 CO 6180436A2
Authority
CO
Colombia
Prior art keywords
substituted
alkyl
optionally substituted
aryl
alkoxy
Prior art date
Application number
CO09056803A
Other languages
Spanish (es)
Inventor
Grier Wallace
Eric Breinlinger
Kevin Cusack
Shanon Fix-Stenzel
Thomas Gordon
Adrian Hobson
Martin Hayes
Graham Ansell
Pintipa Grongsaard
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39562856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6180436(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CO6180436A2 publication Critical patent/CO6180436A2/en

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    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
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Abstract

1.- Un compuesto de la Fórmula Ien donde D es H, N(R5)2 u OR6;X es CH, C(CH3) o N; Y es CH2, O, S o NR3; en donde R3 es hidrógeno, o alquil (C1-C10) recto o ramificado; A es H, hidroxi, -CH2OH, -CH(OH)CH3, -C(O)-OCH3, -C(OH)(CH3)2, -O(CH2)t-COOH, -C(O)-NR6, -(CH2)-P(=O)(OR7)(OR7) opcionalmente substituido, -(CH2)n-O-P(=O)(OR7)(OR7) opcionalmente substituido, -(CH2)n- P(=O)(OR7)(R7) opcionalmente substituido, -CH=CH-P(=O)(OR7)(OR7), C(O)-NHCH3, CN, COOR6 o -R4-COOH, en donde R4 es alquileno (C1-C20) recto o ramificado, alquenileno (C1-C20) recto o ramificado, alquinileno (C1- C20) recto o ramificado, cicloalquil (C3-C20), o azetidinil opcionalmente substituido;R1 y R2 son seleccionados, de forma independiente, a partir del grupo que consiste de hidrógeno, CF3, halógeno, alquil (C1-C20), alcoxi (C1-C20), alquil substituido con cicloalquil (C3-C20), alcoxi substituido con cicloalquil (C3-C20), alquenil (C2-C20), alquenil (C2-C20) substituido con aril, alquinil (C2- C20), alquinil (C2-C20) substituido con aril, aril, alquil (C1-C20) substituido con aril, alquil (C2-C20) substituido con heteroanil, alcoxi substituido con aril, alcoxi substituido con heteroaril, aril substituido con alquil, arilalquil, arilalquil substituido con aril, arilalquil substituido con arilalquil, CN y -O-indolizinil; en donde tales grupos R1 y R2 pueden ser opcionalmente substituidos con uno o más substituyentes seleccionados, de forma independiente, a partir de alquil (C1-C20), CF3, halógeno, hidroxi, alcoxi (C1-C20), OCF3, y CN; en donde uno o más de los átomos de carbono en los grupos R1 o R2 pueden ser independientemente reemplazados con oxígeno que no es de peróxido, azufre o NR8;en donde R8 es hidrógeno o el grupo alquil (C1-C20); en donde uno de R1 y R2 es diferente de hidrógeno; y en donde los grupos alquil, alquenil, y alquinil en R1 y R2 son opcionalmente substituidos con oxo o halógeno; cada R5 es independientemente H, alquil (C1-C3) opcionalmente substituido, o fenil opcionalmente substituido con -C(O)-O-alquil(C1-C3); cada R6 es independientemente H o alquil (C1-C2) opcionalmente substituido; ...1.- A compound of the Formula I in which D is H, N (R5) 2 or OR6, X is CH, C (CH3) or N; Y is CH2, O, S or NR3; wherein R3 is hydrogen, or straight or branched (C1-C10) alkyl; A is H, hydroxy, -CH2OH, -CH (OH) CH3, -C (O) -OCH3, -C (OH) (CH3) 2, -O (CH2) t-COOH, -C (O) -NR6 , - (CH2) -P (= O) (OR7) (OR7) optionally substituted, - (CH2) nOP (= O) (OR7) (OR7) optionally substituted, - (CH2) n- P (= O) ( OR7) (R7) optionally substituted, -CH = CH-P (= O) (OR7) (OR7), C (O) -NHCH3, CN, COOR6 or -R4-COOH, where R4 is alkylene (C1-C20) ) straight or branched, straight or branched alkenylene (C1-C20), straight or branched (C1-C20) alkynylene, cycloalkyl (C3-C20), or optionally substituted azetidinyl; R1 and R2 are independently selected from group consisting of hydrogen, CF3, halogen, (C1-C20) alkyl, (C1-C20) alkoxy, alkyl substituted with cycloalkyl (C3-C20), alkoxy substituted with cycloalkyl (C3-C20), alkenyl (C2-C20) , alkenyl (C2-C20) substituted with aryl, alkynyl (C2-C20), alkynyl (C2-C20) substituted with aryl, aryl, alkyl (C1-C20) substituted with aryl, alkyl (C2-C20) substituted with heteroanil, aryl substituted alkoxy, hete substituted alkoxy roaryl, aryl substituted with alkyl, arylalkyl, arylalkyl substituted with aryl, arylalkyl substituted with arylalkyl, CN and -O-indolizinyl; wherein such R1 and R2 groups may be optionally substituted with one or more substituents independently selected from alkyl (C1-C20), CF3, halogen, hydroxy, (C1-C20) alkoxy, OCF3, and CN; wherein one or more of the carbon atoms in the R1 or R2 groups can be independently replaced with oxygen that is not peroxide, sulfur or NR8, wherein R8 is hydrogen or the (C1-C20) alkyl group; wherein one of R1 and R2 is different from hydrogen; and wherein the alkyl, alkenyl, and alkynyl groups in R1 and R2 are optionally substituted with oxo or halogen; each R5 is independently H, optionally substituted (C1-C3) alkyl, or phenyl optionally substituted with -C (O) -O-(C1-C3) alkyl; each R6 is independently H or optionally substituted (C1-C2) alkyl; ...

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