DOP2009000149A - AGONIST AND ANTAGONIST COMPOUNDS OF THE SPHINGOSINE-1-PHOSPHATE RECEPTOR - Google Patents

AGONIST AND ANTAGONIST COMPOUNDS OF THE SPHINGOSINE-1-PHOSPHATE RECEPTOR

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Publication number
DOP2009000149A
DOP2009000149A DO2009000149A DO2009000149A DOP2009000149A DO P2009000149 A DOP2009000149 A DO P2009000149A DO 2009000149 A DO2009000149 A DO 2009000149A DO 2009000149 A DO2009000149 A DO 2009000149A DO P2009000149 A DOP2009000149 A DO P2009000149A
Authority
DO
Dominican Republic
Prior art keywords
sphingosine
agonist
antagonist compounds
phosphate receptor
receptor family
Prior art date
Application number
DO2009000149A
Other languages
Spanish (es)
Inventor
Grier A Wallace
Eric C Breinlinger
Kevin P Cusack
Shannon R Fix-Stenzel
Thomas D Gordon
Adrian D Hobson
Martin E Hayes
Graham K Ansell
Pintipa Grongsaard
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39562856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2009000149(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of DOP2009000149A publication Critical patent/DOP2009000149A/en

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    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
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    • C07F9/40—Esters thereof
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    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
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    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Abstract

La presente invención se refiere a agentes novedosos, potentes y selectivos que son agonistas o antagonistas de los uno o més receptores individuales de la familia de receptores SIP. Los compuestos de la invención son útiles como agentews terapéuticos por el tratamiento de trastornos clínicos asociados con el agonismo o antagonismo de receptores individuales de la familia de receptore S1P.The present invention relates to novel, potent and selective agents that are agonists or antagonists of the one or more individual receptors of the SIP receptor family. The compounds of the invention are useful as therapeutic agents for the treatment of clinical disorders associated with agonism or antagonism of individual receptors of the S1P receptor family.

DO2009000149A 2006-12-21 2009-06-19 AGONIST AND ANTAGONIST COMPOUNDS OF THE SPHINGOSINE-1-PHOSPHATE RECEPTOR DOP2009000149A (en)

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