MX2009003645A - N-substituted-azacyclylamines as histamine-3 antagonists. - Google Patents
N-substituted-azacyclylamines as histamine-3 antagonists.Info
- Publication number
- MX2009003645A MX2009003645A MX2009003645A MX2009003645A MX2009003645A MX 2009003645 A MX2009003645 A MX 2009003645A MX 2009003645 A MX2009003645 A MX 2009003645A MX 2009003645 A MX2009003645 A MX 2009003645A MX 2009003645 A MX2009003645 A MX 2009003645A
- Authority
- MX
- Mexico
- Prior art keywords
- histamine
- azacyclylamines
- antagonists
- substituted
- variables
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor: (I) wherein the variables are described in the specification.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85014306P | 2006-10-06 | 2006-10-06 | |
PCT/US2007/021474 WO2008045371A2 (en) | 2006-10-06 | 2007-10-05 | N-substituted-azacyclylamines as histamine-3 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009003645A true MX2009003645A (en) | 2009-04-22 |
Family
ID=39166787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009003645A MX2009003645A (en) | 2006-10-06 | 2007-10-05 | N-substituted-azacyclylamines as histamine-3 antagonists. |
Country Status (13)
Country | Link |
---|---|
US (1) | US7935719B2 (en) |
EP (1) | EP2074088A2 (en) |
JP (1) | JP2010505851A (en) |
CN (1) | CN101583596A (en) |
AR (1) | AR063147A1 (en) |
AU (1) | AU2007307105A1 (en) |
BR (1) | BRPI0719950A2 (en) |
CA (1) | CA2665071A1 (en) |
CL (1) | CL2007002899A1 (en) |
MX (1) | MX2009003645A (en) |
PE (1) | PE20081152A1 (en) |
TW (1) | TW200831077A (en) |
WO (1) | WO2008045371A2 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009530274A (en) * | 2006-03-15 | 2009-08-27 | ワイス | N-substituted azacyclylamine compounds as histamine-3 antagonists |
AU2007254232A1 (en) | 2006-05-19 | 2007-11-29 | Wyeth | N-benzoyl-and N-benzylpyrrolidin-3-ylamines as histamine-3 antagonists |
PE20081152A1 (en) | 2006-10-06 | 2008-08-10 | Wyeth Corp | N-SUBSTITUTED AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS |
PE20090720A1 (en) * | 2007-05-24 | 2009-06-11 | Wyeth Corp | DERIVATIVES OF AZACICLYLBENZAMIDE AS ANTAGONISTS OF HISTAMINE-3 |
PE20090812A1 (en) | 2007-07-16 | 2009-06-14 | Wyeth Corp | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS |
EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
US8367679B2 (en) | 2008-12-09 | 2013-02-05 | Merck Sharp & Dohme Corp. | Biaryl carboxamides |
BRPI1011258A2 (en) * | 2009-06-26 | 2016-03-22 | Sanofi Sa | fumarate salts, use thereof, pharmaceutical composition comprising them and processes for preparing said composition and 2- (cyclohexylmethyl) -n- {2 - [(2s) -1-methylporrolidin-2-difumarate monohydrate yl] ethyl} -1,2,3,4-tetrahydroisoquinoline-7-sulfonamide |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
CN104447567B (en) * | 2014-11-02 | 2016-06-29 | 湖南华腾制药有限公司 | A kind of preparation method of 1 substituted benzimidazole derivant |
JP2018526452A (en) | 2015-09-03 | 2018-09-13 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ | DYRK1A small molecule inhibitor and use thereof |
EP3986886A2 (en) * | 2019-06-19 | 2022-04-27 | Grünenthal GmbH | Substituted pyrrolidine amides v |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
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GB1416872A (en) | 1972-03-10 | 1975-12-10 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
US3933829A (en) * | 1974-08-22 | 1976-01-20 | John Wyeth & Brother Limited | 4-Aminoquinoline derivatives |
US4166853A (en) * | 1978-05-05 | 1979-09-04 | The Upjohn Company | Antihypertensive 7-trifluoromethyl-4-aminoquinolones |
US4159331A (en) * | 1978-05-05 | 1979-06-26 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
DK0650476T3 (en) | 1993-04-07 | 2002-07-22 | Otsuka Pharma Co Ltd | Peripheral vasodilating agent containing N-acylated 4-aminopiperidine derivatives as active ingredients |
JPH08225535A (en) | 1994-11-15 | 1996-09-03 | Dai Ichi Seiyaku Co Ltd | Indazole derivative |
IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
ES2210747T3 (en) | 1997-05-01 | 2004-07-01 | Eli Lilly And Company | ANTITROMBOTIC AGENTS. |
WO2001042224A1 (en) | 1999-12-09 | 2001-06-14 | Mitsubishi Pharma Corporation | Carboxyamido derivatives |
ES2325477T3 (en) | 2000-03-31 | 2009-09-07 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | INDOLES REPLACED BY PHENYLL AS ANTAGONISTS OF HISTAMINE RECEIVER H3. |
WO2002046168A1 (en) * | 2000-12-07 | 2002-06-13 | Astrazeneca Ab | Therapeutic benzimidazole compounds |
HN2002000156A (en) | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | BENZAMIDE THIAZOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS TO INHIBIT THE PROLIFERATION OF CELLS AND METHODS FOR THEIR USE. |
ATE447404T1 (en) | 2002-03-29 | 2009-11-15 | Novartis Vaccines & Diagnostic | SUBSTITUTED BENZAZOLES AND THEIR USE AS RAF-KINASE INHIBITORS |
US7276505B2 (en) * | 2003-03-14 | 2007-10-02 | Medigene Limited | Immunomodulating heterocyclic compounds |
CN104193750B (en) * | 2004-05-14 | 2018-04-27 | 千禧药品公司 | Suppress mitotic Compounds and methods for by suppressing aurora kinase |
TW200602314A (en) | 2004-05-28 | 2006-01-16 | Tanabe Seiyaku Co | A novel pyrrolidine compound and a process for preparing the same |
US20060014733A1 (en) | 2004-07-19 | 2006-01-19 | Pfizer Inc | Histamine-3 agonists and antagonists |
DK1786790T3 (en) | 2004-07-26 | 2009-07-20 | Lilly Co Eli | Oxazole derivatives such as histamine H3 receptor substances, preparation and therapeutic applications |
ES2534605T3 (en) * | 2004-08-23 | 2015-04-24 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
UY29149A1 (en) | 2004-10-07 | 2006-05-31 | Boehringer Ingelheim Int | TIAZOLIL-DIHIDRO-INDAZOLES |
US7381732B2 (en) * | 2004-10-26 | 2008-06-03 | Bristol-Myers Squibb Company | Pyrazolobenzamides and derivatives as factor Xa inhibitors |
WO2006078775A1 (en) * | 2005-01-21 | 2006-07-27 | Schering Corporation | Imidazole and benzimidazole derivatives useful as histamine h3 antagonists |
JP2008537953A (en) * | 2005-04-15 | 2008-10-02 | エラン ファーマシューティカルズ,インコーポレイテッド | Novel compounds useful for bradykinin B1 receptor antagonism |
DE102005055515A1 (en) | 2005-07-26 | 2007-02-01 | Huf Hülsbeck & Fürst Gmbh & Co. Kg | Sensor arrangement and method for detecting the resting of an operator body part on an actuating point of a motor vehicle closing device with a sensor-assisted evaluation of the output signal of a proximity sensor |
JP2009530274A (en) | 2006-03-15 | 2009-08-27 | ワイス | N-substituted azacyclylamine compounds as histamine-3 antagonists |
JP2009531320A (en) * | 2006-03-20 | 2009-09-03 | グラクソ グループ リミテッド | Compounds that potentiate AMPA receptors and their use in medicine |
US20070238718A1 (en) | 2006-04-06 | 2007-10-11 | Matthias Grauert | Thiazolyl-dihydro-indazole |
PE20081152A1 (en) | 2006-10-06 | 2008-08-10 | Wyeth Corp | N-SUBSTITUTED AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS |
-
2007
- 2007-10-03 PE PE2007001333A patent/PE20081152A1/en not_active Application Discontinuation
- 2007-10-04 AR ARP070104419A patent/AR063147A1/en unknown
- 2007-10-05 MX MX2009003645A patent/MX2009003645A/en not_active Application Discontinuation
- 2007-10-05 CN CNA2007800373471A patent/CN101583596A/en active Pending
- 2007-10-05 EP EP07839332A patent/EP2074088A2/en not_active Withdrawn
- 2007-10-05 AU AU2007307105A patent/AU2007307105A1/en not_active Abandoned
- 2007-10-05 TW TW096137597A patent/TW200831077A/en unknown
- 2007-10-05 WO PCT/US2007/021474 patent/WO2008045371A2/en active Application Filing
- 2007-10-05 US US11/867,830 patent/US7935719B2/en not_active Expired - Fee Related
- 2007-10-05 CL CL2007002899A patent/CL2007002899A1/en unknown
- 2007-10-05 JP JP2009531479A patent/JP2010505851A/en not_active Withdrawn
- 2007-10-05 CA CA002665071A patent/CA2665071A1/en not_active Abandoned
- 2007-10-05 BR BRPI0719950-3A patent/BRPI0719950A2/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2008045371A2 (en) | 2008-04-17 |
CN101583596A (en) | 2009-11-18 |
US7935719B2 (en) | 2011-05-03 |
CL2007002899A1 (en) | 2008-01-11 |
AU2007307105A1 (en) | 2008-04-17 |
AR063147A1 (en) | 2008-12-30 |
WO2008045371A3 (en) | 2008-06-19 |
US20080119458A1 (en) | 2008-05-22 |
JP2010505851A (en) | 2010-02-25 |
TW200831077A (en) | 2008-08-01 |
EP2074088A2 (en) | 2009-07-01 |
CA2665071A1 (en) | 2008-04-17 |
PE20081152A1 (en) | 2008-08-10 |
BRPI0719950A2 (en) | 2014-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |