MX2009005578A - Derivados de aminoquinazolinas con propiedades reductoras de plaquetas de la sangre. - Google Patents
Derivados de aminoquinazolinas con propiedades reductoras de plaquetas de la sangre.Info
- Publication number
- MX2009005578A MX2009005578A MX2009005578A MX2009005578A MX2009005578A MX 2009005578 A MX2009005578 A MX 2009005578A MX 2009005578 A MX2009005578 A MX 2009005578A MX 2009005578 A MX2009005578 A MX 2009005578A MX 2009005578 A MX2009005578 A MX 2009005578A
- Authority
- MX
- Mexico
- Prior art keywords
- wuth
- blood platelet
- reducing properties
- platelet reducing
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención se refiere al descubrimiento de profármacos de análogos 3- ó 5-sustituidos del agente reductor de plaquetas selectivo anagrelida que tienen potencial reducido para efectos colaterales cardiovasculares y que por lo tanto deben conducir a acatamiento por el paciente y seguridad mejorados en el tratamiento de enfermedades mieloproliferativas; de manera más específica, la presente invención se refiere a profármacos de ciertos derivados de imidazoquinazolina que tienen utilidad como agentes reductores de plaquetas en humanos; los compuestos de la presente invención funcionan inhibiendo la formación de plaquetas de la sangre.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0623749.9A GB0623749D0 (en) | 2006-11-28 | 2006-11-28 | Substituted quinazolines |
PCT/GB2007/050698 WO2008065445A1 (en) | 2006-11-28 | 2007-11-19 | Amino quinazolines derivatives wuth blood platelet reducing properties |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005578A true MX2009005578A (es) | 2009-07-29 |
Family
ID=37671459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005578A MX2009005578A (es) | 2006-11-28 | 2007-11-19 | Derivados de aminoquinazolinas con propiedades reductoras de plaquetas de la sangre. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP2097390A1 (es) |
JP (1) | JP2010511031A (es) |
KR (1) | KR20090089865A (es) |
CN (1) | CN101558048B (es) |
AR (1) | AR064003A1 (es) |
AU (1) | AU2007327048B2 (es) |
BR (1) | BRPI0719568A2 (es) |
CA (1) | CA2670168A1 (es) |
EA (1) | EA017139B1 (es) |
GB (1) | GB0623749D0 (es) |
IL (1) | IL198808A0 (es) |
MX (1) | MX2009005578A (es) |
MY (1) | MY149620A (es) |
TW (1) | TW200829252A (es) |
WO (1) | WO2008065445A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0822970D0 (en) * | 2008-12-17 | 2009-01-21 | Shire Llc | Process for the preparation of anagrelide and analogues |
GB201004495D0 (en) | 2010-03-18 | 2010-05-05 | Shire Llc | Subtituted quinazolines |
CN103254197A (zh) * | 2013-05-29 | 2013-08-21 | 黑龙江大学 | 一种盐酸阿那格雷的制备方法 |
PL3236967T3 (pl) | 2014-12-22 | 2020-04-30 | Suda Pharmaceuticals Ltd | Zapobieganie i leczenie przerzutów u pacjentów z nadpłytkowością typu nowotworowego |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4146718A (en) * | 1978-04-10 | 1979-03-27 | Bristol-Myers Company | Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides |
US6194420B1 (en) * | 1999-11-30 | 2001-02-27 | Roberts Laboratories Inc. | 2-amino-5,6-dichloro-3,4-dihydroquinazoline, its method of making and using and pharmaceutical compositions thereof |
DE10301105B4 (de) * | 2003-01-09 | 2005-11-24 | Chemisch-Pharmazeutisches Labor, Rolf Sachse Gmbh | Verwendung von 2-Amino-2H-chinazolin-Derivaten zur Behandlung von myeloproliferativen Erkrankungen, Bluthochdruck und Bronchodilation |
EA010871B1 (ru) * | 2003-01-23 | 2008-12-30 | Шир Холдингз Аг | Трансдермальные составы и способы лечения тромбоцитемии |
US7700608B2 (en) * | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
-
2006
- 2006-11-28 GB GBGB0623749.9A patent/GB0623749D0/en not_active Ceased
-
2007
- 2007-11-19 WO PCT/GB2007/050698 patent/WO2008065445A1/en active Application Filing
- 2007-11-19 MY MYPI20092152A patent/MY149620A/en unknown
- 2007-11-19 MX MX2009005578A patent/MX2009005578A/es not_active Application Discontinuation
- 2007-11-19 KR KR1020097011681A patent/KR20090089865A/ko not_active Application Discontinuation
- 2007-11-19 JP JP2009538793A patent/JP2010511031A/ja active Pending
- 2007-11-19 BR BRPI0719568-0A patent/BRPI0719568A2/pt not_active IP Right Cessation
- 2007-11-19 EP EP07824910A patent/EP2097390A1/en not_active Withdrawn
- 2007-11-19 EA EA200900742A patent/EA017139B1/ru not_active IP Right Cessation
- 2007-11-19 CA CA002670168A patent/CA2670168A1/en not_active Abandoned
- 2007-11-19 AU AU2007327048A patent/AU2007327048B2/en not_active Ceased
- 2007-11-19 CN CN2007800442221A patent/CN101558048B/zh not_active Expired - Fee Related
- 2007-11-27 TW TW096145029A patent/TW200829252A/zh unknown
- 2007-11-28 AR ARP070105273A patent/AR064003A1/es unknown
-
2009
- 2009-05-19 IL IL198808A patent/IL198808A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0719568A2 (pt) | 2013-12-10 |
MY149620A (en) | 2013-09-13 |
JP2010511031A (ja) | 2010-04-08 |
EP2097390A1 (en) | 2009-09-09 |
TW200829252A (en) | 2008-07-16 |
AU2007327048B2 (en) | 2012-01-12 |
CN101558048B (zh) | 2012-07-25 |
WO2008065445A1 (en) | 2008-06-05 |
AU2007327048A1 (en) | 2008-06-05 |
EA017139B1 (ru) | 2012-10-30 |
IL198808A0 (en) | 2010-02-17 |
GB0623749D0 (en) | 2007-01-10 |
EA200900742A1 (ru) | 2010-08-30 |
AR064003A1 (es) | 2009-03-04 |
KR20090089865A (ko) | 2009-08-24 |
CA2670168A1 (en) | 2008-06-05 |
CN101558048A (zh) | 2009-10-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FA | Abandonment or withdrawal |