MY149620A - Amino quinazolines derivatives with blood platelet reducing properties - Google Patents
Amino quinazolines derivatives with blood platelet reducing propertiesInfo
- Publication number
- MY149620A MY149620A MYPI20092152A MYPI20092152A MY149620A MY 149620 A MY149620 A MY 149620A MY PI20092152 A MYPI20092152 A MY PI20092152A MY PI20092152 A MYPI20092152 A MY PI20092152A MY 149620 A MY149620 A MY 149620A
- Authority
- MY
- Malaysia
- Prior art keywords
- blood platelet
- reducing properties
- platelet reducing
- derivatives
- prodrugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
THIS INVENTION RELATES TO THE DISCOVERY OF PRODRUGS OF 3-OR 5-SUBSTITUTED ANALOGUES OF THE SELECTIVE PLATELET LOWERING AGENT ANAGRELIDE WHICH HAVE REDUCED POTENTIAL FOR CARDIOVASCULAR SIDE-EFFECTS AND WHICH SHOULD THEREFORE LEAD TO IMPROVED PATIENT COMPLIANCE AND SAFETY IN THE TREATMENT OF MYELOPROLIFERATIVE DISEASES. MORE SPECIFICALLY, THE PRESENT INVENTION RELATES TO PRODRUGS OF CERTAIN IMIDAZOQUINAZOLINE DERIVATIVES WHICH HAVE UTILITY AS PLATELET LOWERING AGENTS IN HUMANS. THE COMPOUNDS OF THE PRESENT INVENTION FUNCTION BY INHIBITING THE FORMATION OF BLOOD PLATELET.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0623749.9A GB0623749D0 (en) | 2006-11-28 | 2006-11-28 | Substituted quinazolines |
Publications (1)
Publication Number | Publication Date |
---|---|
MY149620A true MY149620A (en) | 2013-09-13 |
Family
ID=37671459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI20092152A MY149620A (en) | 2006-11-28 | 2007-11-19 | Amino quinazolines derivatives with blood platelet reducing properties |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP2097390A1 (en) |
JP (1) | JP2010511031A (en) |
KR (1) | KR20090089865A (en) |
CN (1) | CN101558048B (en) |
AR (1) | AR064003A1 (en) |
AU (1) | AU2007327048B2 (en) |
BR (1) | BRPI0719568A2 (en) |
CA (1) | CA2670168A1 (en) |
EA (1) | EA017139B1 (en) |
GB (1) | GB0623749D0 (en) |
IL (1) | IL198808A0 (en) |
MX (1) | MX2009005578A (en) |
MY (1) | MY149620A (en) |
TW (1) | TW200829252A (en) |
WO (1) | WO2008065445A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0822970D0 (en) * | 2008-12-17 | 2009-01-21 | Shire Llc | Process for the preparation of anagrelide and analogues |
GB201004495D0 (en) | 2010-03-18 | 2010-05-05 | Shire Llc | Subtituted quinazolines |
CN103254197A (en) * | 2013-05-29 | 2013-08-21 | 黑龙江大学 | Preparation method of anagrelide hydrochloride |
EP3236967B1 (en) | 2014-12-22 | 2019-10-16 | SUDA Pharmaceuticals Ltd | Prevention and treatment of metastatic disease in thrombocytotic cancer patients |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4146718A (en) * | 1978-04-10 | 1979-03-27 | Bristol-Myers Company | Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides |
US6194420B1 (en) * | 1999-11-30 | 2001-02-27 | Roberts Laboratories Inc. | 2-amino-5,6-dichloro-3,4-dihydroquinazoline, its method of making and using and pharmaceutical compositions thereof |
DE10301105B4 (en) * | 2003-01-09 | 2005-11-24 | Chemisch-Pharmazeutisches Labor, Rolf Sachse Gmbh | Use of 2-amino-2H-quinazoline derivatives for the treatment of myeloproliferative disorders, hypertension and bronchodilation |
WO2004064841A1 (en) * | 2003-01-23 | 2004-08-05 | Shire Holdings Ag | Formulation and methods for the treatment of thrombocythemia |
US7700608B2 (en) * | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
-
2006
- 2006-11-28 GB GBGB0623749.9A patent/GB0623749D0/en not_active Ceased
-
2007
- 2007-11-19 CA CA002670168A patent/CA2670168A1/en not_active Abandoned
- 2007-11-19 MX MX2009005578A patent/MX2009005578A/en not_active Application Discontinuation
- 2007-11-19 EA EA200900742A patent/EA017139B1/en not_active IP Right Cessation
- 2007-11-19 BR BRPI0719568-0A patent/BRPI0719568A2/en not_active IP Right Cessation
- 2007-11-19 MY MYPI20092152A patent/MY149620A/en unknown
- 2007-11-19 AU AU2007327048A patent/AU2007327048B2/en not_active Ceased
- 2007-11-19 WO PCT/GB2007/050698 patent/WO2008065445A1/en active Application Filing
- 2007-11-19 KR KR1020097011681A patent/KR20090089865A/en not_active Application Discontinuation
- 2007-11-19 JP JP2009538793A patent/JP2010511031A/en active Pending
- 2007-11-19 CN CN2007800442221A patent/CN101558048B/en not_active Expired - Fee Related
- 2007-11-19 EP EP07824910A patent/EP2097390A1/en not_active Withdrawn
- 2007-11-27 TW TW096145029A patent/TW200829252A/en unknown
- 2007-11-28 AR ARP070105273A patent/AR064003A1/en unknown
-
2009
- 2009-05-19 IL IL198808A patent/IL198808A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2009005578A (en) | 2009-07-29 |
CN101558048A (en) | 2009-10-14 |
EA200900742A1 (en) | 2010-08-30 |
AU2007327048B2 (en) | 2012-01-12 |
AR064003A1 (en) | 2009-03-04 |
TW200829252A (en) | 2008-07-16 |
BRPI0719568A2 (en) | 2013-12-10 |
IL198808A0 (en) | 2010-02-17 |
EA017139B1 (en) | 2012-10-30 |
JP2010511031A (en) | 2010-04-08 |
WO2008065445A1 (en) | 2008-06-05 |
CN101558048B (en) | 2012-07-25 |
EP2097390A1 (en) | 2009-09-09 |
CA2670168A1 (en) | 2008-06-05 |
AU2007327048A1 (en) | 2008-06-05 |
GB0623749D0 (en) | 2007-01-10 |
KR20090089865A (en) | 2009-08-24 |
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