MX2009001351A - Compuestos bioactivos multifuncionales. - Google Patents

Compuestos bioactivos multifuncionales.

Info

Publication number
MX2009001351A
MX2009001351A MX2009001351A MX2009001351A MX2009001351A MX 2009001351 A MX2009001351 A MX 2009001351A MX 2009001351 A MX2009001351 A MX 2009001351A MX 2009001351 A MX2009001351 A MX 2009001351A MX 2009001351 A MX2009001351 A MX 2009001351A
Authority
MX
Mexico
Prior art keywords
bioactive compounds
multifunctional bioactive
immune
disorders
multifunctional
Prior art date
Application number
MX2009001351A
Other languages
English (en)
Inventor
Vladislav I Deigin
Original Assignee
Manus Pharmaceuticals Canada L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Manus Pharmaceuticals Canada L filed Critical Manus Pharmaceuticals Canada L
Publication of MX2009001351A publication Critical patent/MX2009001351A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invención describe compuestos bioactivos multifuncionales de la fórmula (I) constituidos de una parte inmuno-reguladora enlazada a una porción estabilizadora y composiciones farmacéuticas del mismo, útiles en el tratamiento de trastornos inmune y trastornos hemopoyéticos tal como citopema inmune, mieloma múltiple, leucosis de linfoide crónica, linfomas linfocíticos, linfosarcomas.
MX2009001351A 2006-08-04 2007-08-01 Compuestos bioactivos multifuncionales. MX2009001351A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83542806P 2006-08-04 2006-08-04
PCT/CA2007/001357 WO2008014613A1 (en) 2006-08-04 2007-08-01 Multifunctional bioactive compounds

Publications (1)

Publication Number Publication Date
MX2009001351A true MX2009001351A (es) 2009-05-11

Family

ID=38996830

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009001351A MX2009001351A (es) 2006-08-04 2007-08-01 Compuestos bioactivos multifuncionales.

Country Status (11)

Country Link
US (2) US8637521B2 (es)
EP (1) EP2046778B1 (es)
JP (1) JP5357022B2 (es)
CN (1) CN101511823B (es)
AU (1) AU2007280995C1 (es)
BR (1) BRPI0714616A2 (es)
CA (1) CA2659875C (es)
EA (1) EA018548B1 (es)
HK (1) HK1124608A1 (es)
MX (1) MX2009001351A (es)
WO (1) WO2008014613A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
ES2425392T3 (es) 2002-03-20 2013-10-15 Mannkind Corporation Cartucho para un aparato de inhalación
CN101010305B (zh) 2004-08-20 2010-08-11 曼金德公司 二酮哌嗪合成的催化反应
KR101644250B1 (ko) 2004-08-23 2016-07-29 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
AU2006290227B2 (en) 2005-09-14 2012-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
DK1986679T3 (da) 2006-02-22 2017-11-20 Mannkind Corp Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof
CA2571645A1 (en) * 2006-12-19 2008-06-19 Apotex Technologies Inc. Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CA2728230C (en) 2008-06-13 2017-10-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
AU2009259883B2 (en) 2008-06-20 2015-02-05 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
EP2862854A1 (en) * 2008-12-29 2015-04-22 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
JP2012515214A (ja) 2009-01-14 2012-07-05 トヘ サルク インストイトウテ フオル ビオルオギクアル ストウドイエス スクリーニング方法、及びアミロイド病に対し保護する化合物
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
SG176738A1 (en) 2009-06-12 2012-01-30 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
AU2010282169A1 (en) * 2009-08-10 2012-03-08 Immunotech Developments Inc. Vaccine having a peptide adjuvant for eliciting a specific immune response to treat viral infection and other conditions
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
EP2582421A1 (en) 2010-06-21 2013-04-24 MannKind Corporation Dry powder drug delivery system and methods
ES2625858T3 (es) 2011-04-01 2017-07-20 Mannkind Corporation Paquete de tipo blíster para cartuchos farmacéuticos
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CA2852536A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
DK2812372T3 (en) 2012-02-09 2018-11-05 Novus Int Inc HETEROATOM WITH CYCLIC DIMERS
WO2013166110A1 (en) * 2012-05-02 2013-11-07 Yale University Tlr-agonist-conjugated antibody recruiting molecules (tlr_arms)
WO2014012069A2 (en) 2012-07-12 2014-01-16 Mannkind Corporation Dry powder drug delivery systems and methods
US9452143B2 (en) 2012-07-12 2016-09-27 Novus International, Inc. Matrix and layer compositions for protection of bioactives
WO2014016787A2 (en) * 2012-07-24 2014-01-30 Pharma Bio Llc Peptide-based compounds and uses thereof to treat beta-amyloid accumulation
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
BR112016000937A8 (pt) 2013-07-18 2021-06-22 Mannkind Corp formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
CN110054619A (zh) * 2018-01-18 2019-07-26 西北农林科技大学 新型二酮哌嗪类组蛋白去乙酰化酶抑制剂
WO2020041965A1 (en) * 2018-08-28 2020-03-05 Lingdong Technology (Beijing) Co., Ltd Self-driving systems with inventory holder

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006261A (en) * 1973-09-28 1977-02-01 Firmenich S.A. Flavoring with mixtures of theobromine and cyclic dipeptides
US4289759A (en) * 1980-06-23 1981-09-15 Ortho Pharmaceutical Corporation Immunoregulatory diketopiperazine compounds
US4331595A (en) * 1980-06-23 1982-05-25 Ortho Pharmaceutical Corporation Immunoregulatory diketopiperazine compounds
GB8427735D0 (en) * 1984-11-02 1984-12-12 Fujisawa Pharmaceutical Co Piperazine compound
DE3909379A1 (de) 1989-03-22 1990-09-27 Cassella Ag Thienylpiperazine, verfahren zu ihrer herstellung, ihre verwendung sowie diese enthaltende arzneimittel und deren herstellung
US5693338A (en) * 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US6331318B1 (en) * 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
FR2677361A1 (fr) 1991-06-04 1992-12-11 Adir Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
JPH07503456A (ja) 1991-10-28 1995-04-13 サイトラン・リミテッド 医薬的ジペプチド組成物およびその使用法
US5352461A (en) * 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
FR2722787B1 (fr) * 1994-07-21 1996-10-11 Univ Claude Bernard Lyon Composes a activite anthelminthique: dicetopiperazines, precurseurs et analogues
US6103699A (en) * 1996-06-07 2000-08-15 Immunotech Developments Inc. Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
US6060452A (en) * 1996-03-13 2000-05-09 Cytran, Inc. Analogs of L-Glu-L-Trp having pharmacological activity
US5932579A (en) * 1996-06-18 1999-08-03 Affymax Technologies N.V. Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use
JPH10226615A (ja) * 1997-02-18 1998-08-25 Pola Chem Ind Inc アスパラギン酸フェニルアラニン環状ジペプタイド誘導体を含有する組成物
US7026322B2 (en) * 1998-11-12 2006-04-11 Nereus Pharmaceuticals, Inc. Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
DE19937721A1 (de) 1999-08-10 2001-02-15 Max Planck Gesellschaft Neue Diketopiperazine
US6974478B2 (en) 1999-10-22 2005-12-13 Archus Orthopedics, Inc. Prostheses, systems and methods for replacement of natural facet joints with artificial facet joint surfaces
JP2001247566A (ja) * 2000-03-03 2001-09-11 Marine Biotechnol Inst Co Ltd 新規抗カビ活性物質およびその製造法
CN101632669B (zh) * 2000-08-04 2011-05-18 Dmi生物科学公司 二酮基哌嗪和包含它们的组合物的使用方法
US20030171379A1 (en) * 2001-12-28 2003-09-11 Jacobs Robert S. Methods of treating, preventing, or inhibiting inflammation with Mactanamide compounds
JP3846409B2 (ja) 2002-02-15 2006-11-15 株式会社村田製作所 弾性表面波装置、通信装置
KR20120091266A (ko) * 2003-05-15 2012-08-17 디엠아이 바이오사이언시스, 인크 Ｔ-세포 매개성 질환의 치료 방법
KR101644250B1 (ko) * 2004-08-23 2016-07-29 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염

Also Published As

Publication number Publication date
US20140179708A1 (en) 2014-06-26
US9108931B2 (en) 2015-08-18
EA200970178A1 (ru) 2009-08-28
AU2007280995A1 (en) 2008-02-07
CA2659875C (en) 2015-01-27
EP2046778A4 (en) 2010-09-08
CA2659875A1 (en) 2008-02-07
EA018548B1 (ru) 2013-08-30
AU2007280995C1 (en) 2013-05-23
CN101511823B (zh) 2014-07-30
JP2009545534A (ja) 2009-12-24
AU2007280995B2 (en) 2012-05-03
US20100048586A1 (en) 2010-02-25
WO2008014613A1 (en) 2008-02-07
JP5357022B2 (ja) 2013-12-04
CN101511823A (zh) 2009-08-19
HK1124608A1 (en) 2009-07-17
US8637521B2 (en) 2014-01-28
BRPI0714616A2 (pt) 2013-06-11
EP2046778A1 (en) 2009-04-15
EP2046778B1 (en) 2013-12-04

Similar Documents

Publication Publication Date Title
MX2009001351A (es) Compuestos bioactivos multifuncionales.
MX2010005136A (es) Prevencion y tratamiento de infecciones secundarias tras una infeccion viral.
SG145693A1 (en) Amino acid prodrugs
MX2011012366A (es) Mezclas fungicidas sinergeticas.
GEP20146125B (en) Aminopyrimidines as syk inhibitors
PH12013500913A1 (en) Substituted-quinoxaline-type-piperidine compounds and the uses thereof
EA201070238A1 (ru) Соединения пиримидина
TW200612892A (en) Novel compounds
HK1133787A1 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2010142766A3 (en) Pyrimidine derivatives as zap-70 inhibitors
MY158974A (en) Prodrugs comprising an exendin linker conjugate
GEP20156285B (en) Compounds and compositions as trk inhibitors
WO2008064018A8 (en) Thienopyrimidinones for treatment of inflammatory disorders and cancers
GB0625648D0 (en) Compounds
WO2007070598A8 (en) Nucleotide and oligonucleotide prodrugs
TN2012000011A1 (en) Prodrugs comprising an insulin linker conjugate
WO2009147205A3 (en) Synergistic fungicidal mixtures
UA103198C2 (en) Squaramide derivatives as cxcr2 antagonists
MX2010009561A (es) Compuestos amida, composiciones y usos de los mismos.
TN2011000291A1 (en) Purine compounds
WO2008061724A3 (en) Compositions comprising carnosic acid 12-methylether
MX2010003002A (es) Analogos de azacitidina y sus usos.
UA103181C2 (ru) Соединения, которые ингибируют дипептидилпептидазу-iv и фармацевтическая композиция, которая содержит их как активный агент
MX2012006490A (es) Inhibidores azociclicos de hidrolasa de amidas de acidos grasos.
GEP20125547B (en) (aza) indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor

Legal Events

Date Code Title Description
HH Correction or change in general
FG Grant or registration