MX2009000672A - Compuestos con actividad inhibidora de las interacciones ubc13-uev, composiciones farmaceuticas y aplicaciones terapeuticas. - Google Patents
Compuestos con actividad inhibidora de las interacciones ubc13-uev, composiciones farmaceuticas y aplicaciones terapeuticas.Info
- Publication number
- MX2009000672A MX2009000672A MX2009000672A MX2009000672A MX2009000672A MX 2009000672 A MX2009000672 A MX 2009000672A MX 2009000672 A MX2009000672 A MX 2009000672A MX 2009000672 A MX2009000672 A MX 2009000672A MX 2009000672 A MX2009000672 A MX 2009000672A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- unsubstituted
- ethyl
- ubc13
- compound according
- Prior art date
Links
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
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- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| ES200601933A ES2293834B1 (es) | 2006-07-20 | 2006-07-20 | Compuesto con actividad inhibidora de las interacciones ubc13-uev, composiciones farmaceuticas que lo comprenden y sus aplicaciones terapeuticas. |
| PCT/ES2007/000120 WO2008009758A1 (es) | 2006-07-20 | 2007-03-07 | Compuestos con actividad inhibidora de las interacciones ubc13-uev, composiciones farmacéuticas y aplicaciones terapéuticas |
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| MX2009000672A true MX2009000672A (es) | 2009-02-04 |
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| ES (1) | ES2293834B1 (enExample) |
| MX (1) | MX2009000672A (enExample) |
| WO (1) | WO2008009758A1 (enExample) |
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| CA2611944A1 (en) | 2005-06-15 | 2006-12-28 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
| MX2011004859A (es) | 2008-11-07 | 2011-08-03 | Massachusetts Inst Technology | Lipidoides de aminoalcohol y usos de los mismos. |
| ES2727711T3 (es) | 2009-07-30 | 2019-10-18 | Spiral Therapeutics Inc | Compuestos inhibidores de Apaf-1 |
| NZ700688A (en) | 2009-12-01 | 2016-02-26 | Shire Human Genetic Therapies | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| WO2012173677A2 (en) * | 2011-03-23 | 2012-12-20 | Indiana University Research And Technology Corporation | Anticancer therapeutic agents |
| DK2691443T3 (da) | 2011-03-28 | 2021-05-03 | Massachusetts Inst Technology | Konjugerede lipomerer og anvendelser af disse |
| CN103906527B (zh) | 2011-06-08 | 2020-07-10 | 川斯勒佰尔公司 | Mrna递送的脂质纳米颗粒组合物和方法 |
| AU2012328570B2 (en) | 2011-10-27 | 2017-08-31 | Massachusetts Institute Of Technology | Amino acid derivatives functionalized on the n-terminus capable of forming drug encapsulating microspheres and uses thereof |
| US20130236504A1 (en) * | 2012-03-06 | 2013-09-12 | Medical University Of South Carolina | Delivery System for Enhancing Drug Efficacy |
| US20150267192A1 (en) | 2012-06-08 | 2015-09-24 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| WO2014028487A1 (en) | 2012-08-13 | 2014-02-20 | Massachusetts Institute Of Technology | Amine-containing lipidoids and uses thereof |
| ES2708561T3 (es) | 2013-03-14 | 2019-04-10 | Translate Bio Inc | Métodos para la purificación de ARN mensajero |
| EP2968586B1 (en) | 2013-03-14 | 2018-07-25 | Translate Bio, Inc. | Cftr mrna compositions and related methods and uses |
| US9315472B2 (en) | 2013-05-01 | 2016-04-19 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| EP3060258A1 (en) | 2013-10-22 | 2016-08-31 | Shire Human Genetic Therapies, Inc. | Mrna therapy for phenylketonuria |
| KR101988552B1 (ko) | 2013-10-22 | 2019-09-25 | 샤이어 휴먼 지네틱 테라피즈 인크. | 메신저 rna의 전달을 위한 지질 제형 |
| EP4276176A3 (en) | 2013-10-22 | 2024-01-10 | Translate Bio, Inc. | Mrna therapy for argininosuccinate synthetase deficiency |
| JP6295767B2 (ja) | 2014-03-25 | 2018-03-20 | 富士通株式会社 | スイッチ装置、情報処理システムおよびスイッチ装置の制御方法 |
| CA2944800A1 (en) | 2014-04-25 | 2015-10-29 | Shire Human Genetic Therapies, Inc. | Methods for purification of messenger rna |
| EP3148552B1 (en) | 2014-05-30 | 2019-07-31 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| KR102511554B1 (ko) | 2014-06-24 | 2023-03-16 | 샤이어 휴먼 지네틱 테라피즈 인크. | 핵산의 전달용 입체화학적으로 풍부한 조성물 |
| EP3164379A1 (en) | 2014-07-02 | 2017-05-10 | Massachusetts Institute of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| EP4248988A3 (en) | 2015-06-19 | 2023-11-29 | Massachusetts Institute of Technology | Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell |
| EA201991747A1 (ru) | 2017-02-27 | 2020-06-04 | Транслейт Био, Инк. | НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR |
| WO2018213476A1 (en) | 2017-05-16 | 2018-11-22 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr |
| WO2020041793A1 (en) | 2018-08-24 | 2020-02-27 | Translate Bio, Inc. | Methods for purification of messenger rna |
| EP3883592A1 (en) | 2018-11-21 | 2021-09-29 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr |
| WO2020252487A1 (en) * | 2019-06-14 | 2020-12-17 | Children's Hospital Medical Center | Rational therapeutic targeting of oncogenic immune signaling states in myeloid malignancies via the ubiquitin conjugating enzyme ube2n |
| KR20220017075A (ko) | 2020-08-04 | 2022-02-11 | 삼성전자주식회사 | 홈 화면을 복원하는 방법 및 이를 적용한 전자 장치 |
| US20250214975A1 (en) * | 2022-05-19 | 2025-07-03 | Ohio State Innovation Foundation | Peptidyl flavor modifiers |
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| DE4234295A1 (de) * | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| AU741802B2 (en) * | 1997-02-15 | 2001-12-13 | Millennium Pharmaceuticals, Inc. | Treatment of infarcts through inhibition of NF-kappaB |
| WO2002011750A2 (en) * | 2000-08-08 | 2002-02-14 | The Government Of The United States Of America, As Represented By The Secretary Of Health And Human | Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytic pathway |
| ES2169690B1 (es) * | 2000-10-06 | 2004-03-16 | Diverdrugs Sl | Trimeros de n-alquilglicina capaces de proteger a neuronas contra agresiones excitotoxicas, y composiciones que los contienen. |
| TW200538149A (en) | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
| ES2296484B1 (es) * | 2005-11-23 | 2009-04-01 | Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe (90%) | Composicion farmaceutica para inhibir la apoptosis. |
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2006
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2007
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- 2007-03-07 EP EP07730361.8A patent/EP2045251B1/en not_active Not-in-force
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2012
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| US8785430B2 (en) | 2014-07-22 |
| CN101506196A (zh) | 2009-08-12 |
| AU2007275073B2 (en) | 2012-06-07 |
| US20110160189A1 (en) | 2011-06-30 |
| ES2293834B1 (es) | 2009-02-16 |
| EP2045251A1 (en) | 2009-04-08 |
| US8252786B2 (en) | 2012-08-28 |
| CA2658327A1 (en) | 2008-01-24 |
| CN101506196B (zh) | 2013-11-20 |
| CA2658327C (en) | 2013-12-03 |
| US20130237529A1 (en) | 2013-09-12 |
| EP2045251A4 (en) | 2010-12-01 |
| ES2293834A1 (es) | 2008-03-16 |
| JP2009544600A (ja) | 2009-12-17 |
| EP2045251B1 (en) | 2015-11-18 |
| WO2008009758A1 (es) | 2008-01-24 |
| AU2007275073A1 (en) | 2008-01-24 |
| JP5203363B2 (ja) | 2013-06-05 |
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