MX2008016004A - 2-anilino-4-(heterociclo)amino-pirimidinas en calidad de inhibidores de la proteina quinasa c-alfa. - Google Patents
2-anilino-4-(heterociclo)amino-pirimidinas en calidad de inhibidores de la proteina quinasa c-alfa.Info
- Publication number
- MX2008016004A MX2008016004A MX2008016004A MX2008016004A MX2008016004A MX 2008016004 A MX2008016004 A MX 2008016004A MX 2008016004 A MX2008016004 A MX 2008016004A MX 2008016004 A MX2008016004 A MX 2008016004A MX 2008016004 A MX2008016004 A MX 2008016004A
- Authority
- MX
- Mexico
- Prior art keywords
- phenyl
- pyrimidine
- diamine
- biphenyl
- substituted
- Prior art date
Links
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- A61K31/33—Heterocyclic compounds
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Landscapes
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| PCT/US2007/071077 WO2007146981A2 (en) | 2006-06-15 | 2007-06-13 | 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase c-alpha |
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| WO2007146977A1 (en) | 2006-06-15 | 2007-12-21 | Boehringer Ingelheim International Gmbh | 2-anilino-4-aminoalkyleneaminopyrimidines |
| CN101686675A (zh) * | 2007-03-20 | 2010-03-31 | 史密丝克莱恩比彻姆公司 | 化合物 |
| WO2009012421A1 (en) * | 2007-07-17 | 2009-01-22 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
| WO2010083241A2 (en) * | 2009-01-14 | 2010-07-22 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for treatment of inflammatory disorders |
| JP5781942B2 (ja) * | 2009-01-14 | 2015-09-24 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物を用いた炎症性障害の治療法 |
| US8394951B2 (en) | 2009-01-15 | 2013-03-12 | Rigel Pharmaceuticals Inc. | Protein kinase C inhibitors and uses thereof |
| AR076024A1 (es) * | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
| JP2013506686A (ja) | 2009-09-30 | 2013-02-28 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | オートファジー阻害遺伝子産物の変調によりオートファジーを変調する方法 |
| CA2780759A1 (en) | 2009-12-01 | 2011-06-09 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| JP2013517273A (ja) * | 2010-01-13 | 2013-05-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 化合物および方法 |
| JP5607241B2 (ja) | 2010-05-21 | 2014-10-15 | ケミリア・エービー | 新規ピリミジン誘導体 |
| EP2688883B1 (en) | 2011-03-24 | 2016-05-18 | Noviga Research AB | Pyrimidine derivatives |
| WO2013092854A1 (en) | 2011-12-23 | 2013-06-27 | Cellzome Limited | Pyrimidine-2,4-diamine derivatives as kinase inhibitors |
| CN102746255A (zh) * | 2012-07-24 | 2012-10-24 | 安徽中医学院 | 具有抗肿瘤活性的化合物、制备方法及应用 |
| US10202356B2 (en) | 2013-03-14 | 2019-02-12 | Tolero Pharmaceuticals, Inc. | JAK2 and ALK2 inhibitors and methods for their use |
| CA2937447A1 (en) * | 2014-01-29 | 2015-08-06 | Vaxine Pty Ltd | New target for diabetes treatment and prevention. |
| WO2016060963A1 (en) * | 2014-10-14 | 2016-04-21 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| SG11201807010PA (en) * | 2016-02-22 | 2018-09-27 | Hoffmann La Roche | Process for the manufacture of 3-piperazin-1-yl-propylamine derivatives |
| EP3421485A1 (en) | 2017-06-30 | 2019-01-02 | Université de Strasbourg | Peptides for treatment and prevention of hyperglycaemia |
| CA3096984A1 (en) | 2018-04-05 | 2019-10-10 | Sumitomo Dainippon Pharma Oncology, Inc. | Axl kinase inhibitors and use of the same |
| MX2021000977A (es) | 2018-07-26 | 2021-04-12 | Sumitomo Pharma Oncology Inc | Metodos para tratar enfermedades asociadas con expresion anormal de receptor de activina a tipo 1 (acvr1) e inhibidores de acvr1 para uso en los mismos. |
| EP4295846A3 (en) | 2019-05-10 | 2024-02-28 | Deciphera Pharmaceuticals, LLC | Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| PE20220597A1 (es) | 2019-05-10 | 2022-04-22 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos |
| CA3143489A1 (en) | 2019-06-17 | 2020-12-24 | Deciphera Pharmaceuticals, Llc | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
| MX420195B (es) | 2019-07-22 | 2025-02-10 | Lupin Ltd | Compuestos macrocíclicos como agonistas de sting y métodos y usos de los mismos |
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| US2443305A (en) * | 1948-06-15 | Pyrimidine derivatives | ||
| DE833651C (de) | 1943-11-02 | 1952-03-10 | Ici Ltd | Verfahren zur Herstellung von neuen Pyrimidinabkoemmlingen |
| GB587550A (en) | 1944-09-25 | 1947-04-29 | Francis Henry Swinden Curd | New pyrimidine compounds |
| US3445467A (en) | 1964-05-25 | 1969-05-20 | Ciba Geigy Corp | Biphenyl diphenylalkane and diphenylether compounds,amino - substituted on the phenyl rings |
| FR2244520B1 (enExample) | 1973-07-06 | 1977-02-04 | Ugine Kuhlmann | |
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| ATE232521T1 (de) | 1998-03-27 | 2003-02-15 | Janssen Pharmaceutica Nv | Hiv hemmende pyrimidin derivate |
| EP0945442A1 (en) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted pyrimidine derivatives |
| EP1107957B1 (en) * | 1998-08-29 | 2006-10-18 | AstraZeneca AB | Pyrimidine compounds |
| KR20010108394A (ko) * | 1999-03-26 | 2001-12-07 | 다비드 에 질레스 | 신규 화합물 |
| GB9924092D0 (en) * | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
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| GB0016877D0 (en) * | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
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| WO2003032994A2 (de) | 2001-10-17 | 2003-04-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren |
| DE50212771D1 (de) * | 2001-10-17 | 2008-10-23 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
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| JP4423043B2 (ja) * | 2002-01-23 | 2010-03-03 | バイエル ファーマセチカル コーポレーション | Ｒｈｏ−キナーゼ阻害剤 |
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| TW200808705A (en) | 2006-06-15 | 2008-02-16 | Sanofi Aventis | Aryl- and heteroaryl-ethyl-acylguanidine derivatives, their preparation and their application in therapeutics |
| CL2009000600A1 (es) * | 2008-03-20 | 2010-05-07 | Bayer Cropscience Ag | Uso de compuestos de diaminopirimidina como agentes fitosanitarios; compuestos de diaminopirimidina; su procedimiento de preparacion; agente que los contiene; procedimiento para la preparacion de dicho agente; y procedimiento para combatir plagas de animales y/u hongos dañinos patogenos de plantas. |
| CN102089278A (zh) * | 2008-06-11 | 2011-06-08 | Irm责任有限公司 | 用于治疗疟疾的化合物和组合物 |
| CA2739491A1 (en) * | 2008-10-16 | 2010-04-22 | Schering Corporation | Azine derivatives and methods of use thereof |
| US20110071158A1 (en) | 2009-03-18 | 2011-03-24 | Boehringer Ingelheim International Gmbh | New compounds |
| US8410126B2 (en) | 2009-05-29 | 2013-04-02 | Boehringer Ingelheim International Gmbh | Pyrimidine inhibitors of PKTK2 |
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- 2007-06-13 JP JP2009515622A patent/JP2009540013A/ja active Pending
- 2007-06-13 CA CA002653777A patent/CA2653777A1/en not_active Abandoned
- 2007-06-13 AU AU2007257650A patent/AU2007257650A1/en not_active Abandoned
- 2007-06-13 KR KR1020097000717A patent/KR20090019011A/ko not_active Withdrawn
- 2007-06-13 US US11/762,394 patent/US20070293494A1/en not_active Abandoned
- 2007-06-13 EP EP07798482A patent/EP2054392A2/en not_active Withdrawn
- 2007-06-13 WO PCT/US2007/071077 patent/WO2007146981A2/en not_active Ceased
- 2007-06-13 CN CNA2007800303500A patent/CN101506175A/zh active Pending
- 2007-06-14 CL CL2007001749A patent/CL2007001749A1/es unknown
- 2007-06-14 TW TW096121541A patent/TW200815424A/zh unknown
- 2007-06-15 AR ARP070102631A patent/AR061380A1/es not_active Application Discontinuation
-
2008
- 2008-11-24 ZA ZA200809941A patent/ZA200809941B/xx unknown
- 2008-12-11 IL IL195864A patent/IL195864A0/en unknown
-
2009
- 2009-05-14 US US12/465,704 patent/US8354407B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009540013A (ja) | 2009-11-19 |
| CL2007001749A1 (es) | 2008-01-25 |
| CA2653777A1 (en) | 2007-12-21 |
| ZA200809941B (en) | 2009-07-29 |
| WO2007146981A3 (en) | 2008-02-21 |
| US20090227586A1 (en) | 2009-09-10 |
| CN101506175A (zh) | 2009-08-12 |
| AU2007257650A1 (en) | 2007-12-21 |
| RU2008152195A (ru) | 2010-07-20 |
| WO2007146981A2 (en) | 2007-12-21 |
| US20070293494A1 (en) | 2007-12-20 |
| AR061380A1 (es) | 2008-08-20 |
| BRPI0713696A2 (pt) | 2012-11-06 |
| US8354407B2 (en) | 2013-01-15 |
| EP2054392A2 (en) | 2009-05-06 |
| IL195864A0 (en) | 2009-09-01 |
| TW200815424A (en) | 2008-04-01 |
| KR20090019011A (ko) | 2009-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |