MX2008011018A - Inhibidores de receptor sigma. - Google Patents
Inhibidores de receptor sigma.Info
- Publication number
- MX2008011018A MX2008011018A MX2008011018A MX2008011018A MX2008011018A MX 2008011018 A MX2008011018 A MX 2008011018A MX 2008011018 A MX2008011018 A MX 2008011018A MX 2008011018 A MX2008011018 A MX 2008011018A MX 2008011018 A MX2008011018 A MX 2008011018A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- unsubstituted
- cyclohexyl
- pyrazol
- yloxy
- Prior art date
Links
- 108010085082 sigma receptors Proteins 0.000 title abstract description 5
- 239000003112 inhibitor Substances 0.000 title description 5
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- 238000011282 treatment Methods 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 15
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- 238000011321 prophylaxis Methods 0.000 claims abstract description 7
- 230000008569 process Effects 0.000 claims abstract description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 56
- 125000000217 alkyl group Chemical group 0.000 claims description 54
- -1 pyrrolidin-l-yl Chemical group 0.000 claims description 52
- 125000003118 aryl group Chemical group 0.000 claims description 45
- 229910052739 hydrogen Inorganic materials 0.000 claims description 45
- 239000001257 hydrogen Substances 0.000 claims description 43
- 229910052736 halogen Inorganic materials 0.000 claims description 40
- 150000002367 halogens Chemical class 0.000 claims description 40
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 39
- 125000003342 alkenyl group Chemical group 0.000 claims description 37
- 150000003839 salts Chemical class 0.000 claims description 36
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 29
- 125000004432 carbon atom Chemical group C* 0.000 claims description 29
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- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 28
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 24
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 17
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 16
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 16
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
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Classifications
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06004198A EP1829866A1 (en) | 2006-03-02 | 2006-03-02 | Sigma receptor inhibitors |
| PCT/EP2007/001826 WO2007098963A1 (en) | 2006-03-02 | 2007-03-02 | Sigma receptor inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008011018A true MX2008011018A (es) | 2009-01-07 |
Family
ID=36372388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008011018A MX2008011018A (es) | 2006-03-02 | 2007-03-02 | Inhibidores de receptor sigma. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8088812B2 (enExample) |
| EP (2) | EP1829866A1 (enExample) |
| JP (1) | JP2009528317A (enExample) |
| CN (1) | CN101395138B (enExample) |
| CA (1) | CA2640753A1 (enExample) |
| ES (1) | ES2392193T3 (enExample) |
| MX (1) | MX2008011018A (enExample) |
| PT (1) | PT1996554E (enExample) |
| WO (1) | WO2007098963A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2395003A1 (en) * | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazole compounds as sigma receptor inhibitors |
| EP2415471A1 (en) * | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| EP2631236A1 (en) * | 2012-02-21 | 2013-08-28 | Laboratorios Del. Dr. Esteve, S.A. | Substituted pyrazolo[1,5-a]pyridines, their preparation and use as medicaments |
| MX2016007285A (es) | 2013-12-17 | 2016-08-04 | Esteve Labor Dr | Combinaciones de inhibidores de la captacion de serotonina-norepinefrina (irsn) y ligandos de receptores sigma. |
| EP3328365A1 (en) * | 2015-07-31 | 2018-06-06 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma receptor ligands in dyslipidemia |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2301250A1 (fr) | 1975-02-21 | 1976-09-17 | Bellon Labor Sa Roger | Nouveaux diaryl-1, 4o-aminoalcoxy-3 pyrazoles et leurs sels |
| FR2460299A1 (fr) | 1979-07-05 | 1981-01-23 | Bellon Labor Sa Roger | Nouveaux derives du pyrazole et leur application therapeutique |
| FR2472564A1 (fr) | 1979-12-31 | 1981-07-03 | Bellon Labor Sa Roger | Nouveaux aryl-1 arylsulfonyl-4 1h-pyrazolols-3, et procede pour les preparer |
| GB8917069D0 (en) | 1989-07-26 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
| IL96507A0 (en) | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| WO1991009594A1 (en) | 1989-12-28 | 1991-07-11 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| EP0445974A3 (en) | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
| NZ243065A (en) | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| DE4341749A1 (de) * | 1993-12-08 | 1995-06-14 | Kali Chemie Pharma Gmbh | 3-(Phenylalkylaminoalkyloxy)-5-phenylpyrazol- Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US5547967A (en) * | 1993-12-08 | 1996-08-20 | Kali-Chemie Pharma Gmbh | (Phenylalkylaminoalkyloxy)-heteroaryl-compounds, processes and intermediates for their production and pharmaceutical compositions containing them |
| GB9824310D0 (en) * | 1998-11-05 | 1998-12-30 | Univ London | Activators of soluble guanylate cyclase |
| US6492529B1 (en) | 2000-01-18 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Bis pyrazole-1H-pyrazole intermediates and their synthesis |
| US6884804B2 (en) | 2001-05-16 | 2005-04-26 | Vertex Pharmaceuticals Incorporated | Inhibitors of Src and other protein kinases |
| WO2002102387A1 (en) | 2001-06-18 | 2002-12-27 | H. Lundbeck A/S | Treatment of neuropathic pain |
| WO2004016592A1 (en) | 2002-08-14 | 2004-02-26 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| TW200413351A (en) | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
| WO2005023247A1 (en) * | 2003-09-03 | 2005-03-17 | Smithkline Beecham Corporation | Compounds and methods |
| CA2550257A1 (en) * | 2003-12-18 | 2005-07-07 | Cv Therapeutics, Inc. | 1-akan-2-ol substituted piperazine and piperidine compounds |
| MX2007001530A (es) * | 2004-08-09 | 2007-04-23 | Abbott Gmbh & Co Kg | Compuestos de 4-piperazinil-pirimidina adecuados para tratar trastornos que responde a la modulacion del receptor dopamina d3. |
| BRPI0514692A (pt) * | 2004-08-27 | 2008-06-17 | Esteve Labor Dr | inibidores do receptor sigma |
| US8202872B2 (en) * | 2006-03-01 | 2012-06-19 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
-
2006
- 2006-03-02 EP EP06004198A patent/EP1829866A1/en not_active Withdrawn
-
2007
- 2007-03-02 PT PT07723021T patent/PT1996554E/pt unknown
- 2007-03-02 WO PCT/EP2007/001826 patent/WO2007098963A1/en not_active Ceased
- 2007-03-02 CN CN2007800074821A patent/CN101395138B/zh not_active Expired - Fee Related
- 2007-03-02 JP JP2008556725A patent/JP2009528317A/ja active Pending
- 2007-03-02 MX MX2008011018A patent/MX2008011018A/es active IP Right Grant
- 2007-03-02 CA CA002640753A patent/CA2640753A1/en not_active Abandoned
- 2007-03-02 EP EP07723021A patent/EP1996554B1/en not_active Not-in-force
- 2007-03-02 ES ES07723021T patent/ES2392193T3/es active Active
- 2007-03-02 US US12/281,314 patent/US8088812B2/en not_active Expired - Fee Related
-
2011
- 2011-11-14 US US13/295,315 patent/US20120059006A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1829866A1 (en) | 2007-09-05 |
| JP2009528317A (ja) | 2009-08-06 |
| CA2640753A1 (en) | 2007-09-07 |
| HK1124055A1 (en) | 2009-07-03 |
| ES2392193T3 (es) | 2012-12-05 |
| CN101395138B (zh) | 2012-10-31 |
| US20120059006A1 (en) | 2012-03-08 |
| EP1996554B1 (en) | 2012-08-08 |
| EP1996554A1 (en) | 2008-12-03 |
| PT1996554E (pt) | 2012-11-02 |
| CN101395138A (zh) | 2009-03-25 |
| WO2007098963A1 (en) | 2007-09-07 |
| US20090247525A1 (en) | 2009-10-01 |
| US8088812B2 (en) | 2012-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |