MX2007015848A - Variantes geneticas en el gen tcf7l2 como marcadores de diagnostico para el riesgo de diabetes mellitus tipo 2. - Google Patents
Variantes geneticas en el gen tcf7l2 como marcadores de diagnostico para el riesgo de diabetes mellitus tipo 2.Info
- Publication number
- MX2007015848A MX2007015848A MX2007015848A MX2007015848A MX2007015848A MX 2007015848 A MX2007015848 A MX 2007015848A MX 2007015848 A MX2007015848 A MX 2007015848A MX 2007015848 A MX2007015848 A MX 2007015848A MX 2007015848 A MX2007015848 A MX 2007015848A
- Authority
- MX
- Mexico
- Prior art keywords
- type
- risk
- diabetes mellitus
- genetic variants
- diagnostic markers
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69217405P | 2005-06-20 | 2005-06-20 | |
| US75715506P | 2006-01-06 | 2006-01-06 | |
| PCT/IS2006/000014 WO2006137085A1 (en) | 2005-06-20 | 2006-06-16 | Genetic variants in the tcf7l2 gene as diagnostic markers for risk of type 2 diabetes mellitus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007015848A true MX2007015848A (es) | 2008-04-22 |
Family
ID=37036993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007015848A MX2007015848A (es) | 2005-06-20 | 2006-06-16 | Variantes geneticas en el gen tcf7l2 como marcadores de diagnostico para el riesgo de diabetes mellitus tipo 2. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7585630B2 (enExample) |
| EP (1) | EP1907569B1 (enExample) |
| JP (1) | JP5301987B2 (enExample) |
| KR (1) | KR101374304B1 (enExample) |
| CN (1) | CN101238222B (enExample) |
| AU (1) | AU2006260477B2 (enExample) |
| BR (1) | BRPI0612301A2 (enExample) |
| CA (1) | CA2612475C (enExample) |
| EA (1) | EA016397B1 (enExample) |
| IL (1) | IL188147A (enExample) |
| MX (1) | MX2007015848A (enExample) |
| NO (1) | NO341910B1 (enExample) |
| NZ (1) | NZ564285A (enExample) |
| WO (1) | WO2006137085A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| KR101374304B1 (ko) * | 2005-06-20 | 2014-03-14 | 디코드 제네틱스 이에이치에프 | 타입 2 당뇨병의 위험에 대한 진단 마커인 tcf7l2유전자의 유전적 변이체 |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| EP2540725A1 (de) | 2006-05-04 | 2013-01-02 | Boehringer Ingelheim International GmbH | Polymorphe von 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| US20100086921A1 (en) * | 2006-11-30 | 2010-04-08 | Valgerdur Steinthorsdottir | Genetic susceptibility variants of type 2 diabetes mellitus |
| EP2057183A2 (en) * | 2007-03-01 | 2009-05-13 | Novetide Ltd. | High purity peptides |
| EP2155903A4 (en) * | 2007-04-30 | 2010-12-01 | Compugen Ltd | ALLELIC POLYMORPHISM ASSOCIATED WITH DIABETES |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| JP2012502081A (ja) | 2008-09-10 | 2012-01-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病及び関連症状の治療のための組み合わせ治療 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| MX2011006713A (es) | 2008-12-23 | 2011-07-13 | Boehringer Ingelheim Int | Formas salinas de compuesto organico. |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| US8796182B2 (en) | 2009-07-10 | 2014-08-05 | Decode Genetics Ehf. | Genetic markers associated with risk of diabetes mellitus |
| KR20120107080A (ko) * | 2009-11-27 | 2012-09-28 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 dpp-iv 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CN107961377B (zh) | 2010-05-05 | 2022-11-22 | 勃林格殷格翰国际有限公司 | 组合疗法 |
| KR20130093012A (ko) | 2010-06-24 | 2013-08-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| EP3517539B1 (en) | 2011-07-15 | 2022-12-14 | Boehringer Ingelheim International GmbH | Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
| WO2013171166A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp-4 inhibitor for use in the treatment of sirs and/or sepsis |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| EP2971163A4 (en) * | 2013-03-14 | 2017-03-22 | The Children's Hospital of Philadelphia | Tcf7l2 variant and methods of use thereof in diagnostic and drug screening assays |
| RU2521202C1 (ru) * | 2013-04-12 | 2014-06-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" | Способ прогнозирования риска развития сахарного диабета второго типа у больных гипертонической болезнью |
| JP6615109B2 (ja) | 2014-02-28 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Dpp−4阻害薬の医学的使用 |
| CN103882127B (zh) * | 2014-03-13 | 2016-03-16 | 河北联合大学 | 用于预测患2型糖尿病肾病发生风险的试剂盒 |
| WO2016201438A1 (en) * | 2015-06-11 | 2016-12-15 | The Children's Hospital Of Philadelphia | New targets modulated by a casual variant of type 2 diabetes (t2d) embedded within the tcf7l2 gene and methods of use thereof for identifying agents having efficacy for the treatment of type 2 diabetes and other metabolic disorders |
| MX390363B (es) | 2016-06-10 | 2025-03-20 | Boehringer Ingelheim Int | Combinacion de linagliptina y metformina |
| CN109182508A (zh) * | 2018-10-22 | 2019-01-11 | 北京华夏时代生物工程有限公司 | Tcf7l2基因单核苷酸多态性的荧光原位杂交测序方法 |
| TWI702292B (zh) * | 2018-12-28 | 2020-08-21 | 薩摩亞商康多富國際有限公司 | 個人化新陳代謝疾病保健食品組合的決定方法及非暫態電腦可讀取儲存媒體 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US5288611A (en) * | 1983-01-10 | 1994-02-22 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
| JPS60501339A (ja) * | 1983-01-10 | 1985-08-22 | ジエン−プロ−ブ インコ−ポレィテッド | 生物を検出、同定又は定量する方法およびキット |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| DE3534934A1 (de) * | 1985-10-01 | 1987-04-02 | Draegerwerk Ag | Kolorimetrisches gasdosimeter |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5256775A (en) * | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5424186A (en) * | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5264564A (en) * | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5837832A (en) * | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5858659A (en) * | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US6057117A (en) | 1996-04-04 | 2000-05-02 | Chiron Corporation | Identification and use of selective inhibitors of glycogen synthase kinase 3 |
| US6153618A (en) | 1996-10-11 | 2000-11-28 | Chiron Corporation | Inhibitors of glycogen synthase 3 kinase |
| WO1999065897A1 (en) | 1998-06-19 | 1999-12-23 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| US6512102B1 (en) | 1998-12-31 | 2003-01-28 | Chiron Corporation | Compositions and methods of diagnosis and treatment using casein kinase I |
| KR100688308B1 (ko) | 1999-12-17 | 2007-02-28 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 글리코겐 신타아제 키나제3의 피라진 기제 저해제 |
| WO2001044246A1 (en) | 1999-12-17 | 2001-06-21 | Chiron Corporation | Bicyclic inhibitors of glycogen synthase kinase 3 |
| JP2004504838A (ja) | 2000-07-27 | 2004-02-19 | カイロン コーポレイション | Gsk3ポリペプチド |
| AU785425B2 (en) * | 2001-03-30 | 2007-05-17 | Genetic Technologies Limited | Methods of genomic analysis |
| JP2004536113A (ja) | 2001-07-03 | 2004-12-02 | カイロン コーポレイション | チロシンキナーゼおよびセリン/スレオニンキナーゼのインヒビターとしてのインダゾールベンズイミダゾール化合物 |
| US20030170665A1 (en) * | 2001-08-04 | 2003-09-11 | Whitehead Institute For Biomedical Research | Haplotype map of the human genome and uses therefor |
| WO2003024447A1 (en) | 2001-09-20 | 2003-03-27 | Smithkline Beecham Corporation | Inhibitors of glycogen synthase kinase-3 |
| US20040072831A1 (en) | 2001-10-12 | 2004-04-15 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US20040023237A1 (en) * | 2001-11-26 | 2004-02-05 | Perelegen Sciences Inc. | Methods for genomic analysis |
| US6762185B1 (en) | 2002-03-01 | 2004-07-13 | Choongwae Pharma Corporation | Compounds useful for treatment of cancer, compositions containing the same, and methods of their use |
| EP1380644A1 (en) | 2002-07-08 | 2004-01-14 | Kylix B.V. | The use of specified TCF target genes to identify drugs for the treatment of cancer, in particular colorectal cancer, in which TCF/beta-catenin/WNT signalling plays a central role |
| BR0313743A (pt) | 2002-08-23 | 2005-07-05 | Chiron Corp | Benzimidazol quinolinonas e usos destas |
| EP1549144A4 (en) | 2002-10-04 | 2010-01-06 | Univ California | METHOD FOR THE TREATMENT OF CANCER BY INHIBITION OF THE WNT SIGNALING LINE |
| JP2006506988A (ja) * | 2002-11-01 | 2006-03-02 | デコード ジェネティクス イーエッチエフ. | 染色体5q35に位置したヒトII型糖尿病遺伝子−SLIT−3 |
| US20040146870A1 (en) * | 2003-01-27 | 2004-07-29 | Guochun Liao | Systems and methods for predicting specific genetic loci that affect phenotypic traits |
| CN1548553A (zh) * | 2003-05-21 | 2004-11-24 | 中国医学科学院基础医学研究所 | 用于预测2型糖尿病易感性的试剂盒及引物 |
| US6991110B2 (en) * | 2003-07-02 | 2006-01-31 | Inficon, Inc. | Package for storing sensor crystals and related method of use |
| KR20060121842A (ko) | 2003-08-28 | 2006-11-29 | 주식회사 중외제약 | β-카테닌/TCF에 의해 활성화되는 전사의 조절 |
| KR101374304B1 (ko) * | 2005-06-20 | 2014-03-14 | 디코드 제네틱스 이에이치에프 | 타입 2 당뇨병의 위험에 대한 진단 마커인 tcf7l2유전자의 유전적 변이체 |
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2006
- 2006-06-16 KR KR1020087001376A patent/KR101374304B1/ko not_active Expired - Fee Related
- 2006-06-16 JP JP2008517701A patent/JP5301987B2/ja not_active Expired - Fee Related
- 2006-06-16 CN CN2006800221296A patent/CN101238222B/zh not_active Expired - Fee Related
- 2006-06-16 BR BRPI0612301-5A patent/BRPI0612301A2/pt not_active Application Discontinuation
- 2006-06-16 CA CA2612475A patent/CA2612475C/en active Active
- 2006-06-16 US US11/454,296 patent/US7585630B2/en active Active
- 2006-06-16 WO PCT/IS2006/000014 patent/WO2006137085A1/en not_active Ceased
- 2006-06-16 EA EA200800087A patent/EA016397B1/ru not_active IP Right Cessation
- 2006-06-16 MX MX2007015848A patent/MX2007015848A/es active IP Right Grant
- 2006-06-16 NZ NZ564285A patent/NZ564285A/en not_active IP Right Cessation
- 2006-06-16 EP EP06745230.0A patent/EP1907569B1/en active Active
- 2006-06-16 AU AU2006260477A patent/AU2006260477B2/en not_active Ceased
-
2007
- 2007-12-13 IL IL188147A patent/IL188147A/en active IP Right Grant
-
2008
- 2008-01-21 NO NO20080389A patent/NO341910B1/no not_active IP Right Cessation
-
2009
- 2009-06-15 US US12/456,381 patent/US20090275043A1/en not_active Abandoned
-
2011
- 2011-11-11 US US13/294,802 patent/US20120149016A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR101374304B1 (ko) | 2014-03-14 |
| HK1117569A1 (en) | 2009-01-16 |
| AU2006260477A8 (en) | 2006-12-28 |
| NO20080389L (no) | 2008-01-21 |
| CN101238222B (zh) | 2013-04-10 |
| EP1907569A1 (en) | 2008-04-09 |
| EA200800087A1 (ru) | 2008-06-30 |
| AU2006260477B2 (en) | 2012-02-23 |
| KR20080051128A (ko) | 2008-06-10 |
| CN101238222A (zh) | 2008-08-06 |
| US20120149016A1 (en) | 2012-06-14 |
| JP5301987B2 (ja) | 2013-09-25 |
| US7585630B2 (en) | 2009-09-08 |
| NZ564285A (en) | 2010-03-26 |
| EP1907569B1 (en) | 2013-04-10 |
| JP2008546403A (ja) | 2008-12-25 |
| BRPI0612301A2 (pt) | 2009-01-27 |
| EA016397B1 (ru) | 2012-04-30 |
| AU2006260477A1 (en) | 2006-12-28 |
| US20090275043A1 (en) | 2009-11-05 |
| NO341910B1 (no) | 2018-02-19 |
| IL188147A (en) | 2013-02-28 |
| CA2612475A1 (en) | 2006-12-28 |
| WO2006137085A1 (en) | 2006-12-28 |
| US20060286588A1 (en) | 2006-12-21 |
| CA2612475C (en) | 2015-07-28 |
| IL188147A0 (en) | 2008-03-20 |
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