MX2007011512A - Compuestos que tienen actividad para corregir procesamiento de cftr-mutante y usos de los mismos. - Google Patents
Compuestos que tienen actividad para corregir procesamiento de cftr-mutante y usos de los mismos.Info
- Publication number
- MX2007011512A MX2007011512A MX2007011512A MX2007011512A MX2007011512A MX 2007011512 A MX2007011512 A MX 2007011512A MX 2007011512 A MX2007011512 A MX 2007011512A MX 2007011512 A MX2007011512 A MX 2007011512A MX 2007011512 A MX2007011512 A MX 2007011512A
- Authority
- MX
- Mexico
- Prior art keywords
- containing compounds
- compounds
- activity
- mutant
- cftr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66350105P | 2005-03-18 | 2005-03-18 | |
PCT/US2006/008267 WO2006101740A2 (en) | 2005-03-18 | 2006-03-08 | Compounds having activity in correcting mutant-cftr processing and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007011512A true MX2007011512A (es) | 2007-12-07 |
Family
ID=37024308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007011512A MX2007011512A (es) | 2005-03-18 | 2006-03-08 | Compuestos que tienen actividad para corregir procesamiento de cftr-mutante y usos de los mismos. |
Country Status (12)
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
PL1773816T3 (pl) | 2004-06-24 | 2015-06-30 | Vertex Pharma | Modulatory transporterów posiadających kasetę wiążącą ATP |
CA2635214A1 (en) * | 2005-12-27 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Compounds useful in cftr assays and methods therewith |
WO2007079139A2 (en) | 2005-12-28 | 2007-07-12 | Vertex Pharmaceuticals, Inc. | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
PL2007756T3 (pl) | 2006-04-07 | 2016-01-29 | Vertex Pharma | Modulatory transporterów posiadających kasetę wiążącą ATP |
US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
CN101096363B (zh) * | 2006-06-27 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途 |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
US8283351B2 (en) | 2007-04-02 | 2012-10-09 | Institute For Oneworld Health | Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof |
CN101687851B (zh) | 2007-05-07 | 2013-02-27 | 诺瓦提斯公司 | 有机化合物 |
US20110177999A1 (en) * | 2007-08-09 | 2011-07-21 | Vertex Pharmaceuticals Incorporated | Therapeutic Combinations Useful in Treating CFTR Related Diseases |
NZ585236A (en) | 2007-10-09 | 2012-03-30 | Merck Patent Gmbh | Pyridine derivatives useful as glucokinase activators |
WO2009051909A1 (en) * | 2007-10-16 | 2009-04-23 | The Regents Of The University Of California | Compounds having activity in correcting mutant-cftr cellular processing and uses thereof |
US8507524B2 (en) | 2007-11-16 | 2013-08-13 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette-transporters |
BRPI0821039B8 (pt) | 2007-12-07 | 2021-05-25 | Vertex Pharma | formas sólidas de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico, processo de preparação das mesmas, composições farmacêuticas compreendendo as mesmas e usos |
AU2008334629B2 (en) | 2007-12-10 | 2012-04-12 | Novartis Ag | Organic compounds |
AU2009231993B2 (en) | 2008-03-31 | 2013-10-10 | Vertex Pharmaceuticals Incorporated | Pyridyl derivatives as CFTR modulators |
WO2009131951A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising isoxazole derivatives |
US8207205B2 (en) * | 2008-04-21 | 2012-06-26 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
US20100099677A1 (en) * | 2008-04-21 | 2010-04-22 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Thiazole Derivatives |
US8236808B2 (en) | 2008-06-10 | 2012-08-07 | Novartis Ag | Pyrazine derivatives as ENAC blockers |
US20120058918A1 (en) * | 2009-02-02 | 2012-03-08 | Chromocell Corporation | Cell lines expressing cftr and methods of using them |
EP2408750B1 (en) | 2009-03-20 | 2015-08-26 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
US8343976B2 (en) | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
US10253020B2 (en) | 2009-06-12 | 2019-04-09 | Abivax | Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging |
JP2013508414A (ja) | 2009-10-22 | 2013-03-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症および他の慢性疾患の治療のための組成物 |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
CN109081804B (zh) | 2010-03-25 | 2021-12-10 | 弗特克斯药品有限公司 | 环丙烷甲酰胺的固体形式 |
JP2013523833A (ja) | 2010-04-07 | 2013-06-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | 3−(6−(1−(2,2−ジフルオロベンゾ[d][1,3]ジオキソール−5−イル)シクロプロパンカルボキサミド)−3−メチルピリジン−2−イル)安息香酸の医薬組成物およびその投与 |
WO2011127290A2 (en) | 2010-04-07 | 2011-10-13 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
SG184987A1 (en) | 2010-04-22 | 2012-11-29 | Vertex Pharma | Process of producing cycloalkylcarboxamido-indole compounds |
US8563593B2 (en) | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
AU2011293658B2 (en) | 2010-08-23 | 2015-03-05 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof |
EP2826771B1 (en) | 2010-09-14 | 2018-12-12 | Instytut Biochemii I Biofizyki Polskiej Akademii Nauk | Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction |
US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
CA2754237A1 (en) | 2011-05-27 | 2012-11-27 | The Regents Of The University Of California | Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof |
WO2012166654A1 (en) * | 2011-05-27 | 2012-12-06 | The Regents Of The University Of California | Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof |
US8883473B2 (en) | 2011-06-29 | 2014-11-11 | Janssen Pharmaceutica N.V. | Methods of treatment using allosteric processing inhibitors for matrix metalloproteinases |
WO2013003358A2 (en) | 2011-06-29 | 2013-01-03 | Janssen Pharmaceutica Nv | Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases |
CA2840202A1 (en) | 2011-06-29 | 2013-01-03 | Janssen Pharmaceutica Nv | Crystal structure of the pro form of a matrix metalloproteinase and an allosteric processing inhibitor |
CA2852991C (en) | 2011-11-08 | 2019-12-31 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
CA3128556A1 (en) | 2012-01-25 | 2013-08-01 | Vertex Pharmaceuticals Incorporated | Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
CA2865519C (en) | 2012-02-27 | 2018-01-02 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl0-5-hydroxyphenyl-1]-1,4-dihydro-4-oxoquinolone-3-carboxamide for treating cystic fibrosis |
US8809340B2 (en) | 2012-03-19 | 2014-08-19 | Novartis Ag | Crystalline form |
WO2014014841A1 (en) | 2012-07-16 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof |
HRP20181740T4 (hr) | 2012-11-02 | 2024-01-05 | Vertex Pharmaceuticals Incorporated | Farmaceutski pripravci za liječenje bolesti koje su posredovane s cftr |
ITMI20122065A1 (it) | 2012-12-03 | 2014-06-04 | Univ Padova | Uso dei correttori del cftr nel trattamento delle patologie del muscolo striato |
EP2757161A1 (en) | 2013-01-17 | 2014-07-23 | Splicos | miRNA-124 as a biomarker of viral infection |
GB201405991D0 (en) * | 2014-04-03 | 2014-05-21 | Cambridge Entpr Ltd | Novel compounds |
SI3424534T1 (sl) | 2014-04-15 | 2021-08-31 | Vertex Pharmaceutical Incorporated | Farmacevtski sestavki za zdravljenje bolezni, ki jih povzroča regulator transmembranske prevodnosti pri cistični fibrozi |
EP2974729A1 (en) | 2014-07-17 | 2016-01-20 | Abivax | Quinoline derivatives for use in the treatment of inflammatory diseases |
RU2020134082A (ru) | 2014-10-06 | 2020-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Модуляторы регулятора трансмембранной проводимости при муковисцидозе |
MX370450B (es) | 2014-10-07 | 2019-12-13 | Vertex Pharma | Co-cristales de moduladores de regulador de conductancia de transmembrana en fibrosis quistica. |
CA2969587A1 (en) | 2014-12-05 | 2016-06-09 | Centre National De La Recherche Scientifique (Cnrs) | Compounds for treating cystic fibrosis |
US10828288B2 (en) | 2015-01-27 | 2020-11-10 | Rutgers, The State University Of New Jersey | Hydrazone derivatives for the treatment of cancer |
US10729671B2 (en) | 2015-01-27 | 2020-08-04 | Rutgers, The State University Of New Jersey | Zinc complexes of hydrazones and (thio)semicarbazones and their use for the treatment of cancer |
WO2016123246A1 (en) | 2015-01-27 | 2016-08-04 | Rutgers, The State University Of New Jersey | (thio, oxo and seleno) semicarbazone complexes with zinc and their use for treating cancer |
WO2016123242A1 (en) | 2015-01-27 | 2016-08-04 | Rutgers, The State University Of New Jersey | (thio)semicarbazone derivatives and their use for treating cancer |
BR112017016205A2 (pt) | 2015-02-09 | 2018-03-27 | Romani Luigina | thymosin alpha 1 para uso no tratamento de fibrose cística |
ITUB20153714A1 (it) * | 2015-09-18 | 2017-03-18 | Luigina Romani | Timosina alfa 1 per l?uso nel trattamento della fibrosi cistica. |
WO2017060880A1 (en) * | 2015-10-09 | 2017-04-13 | AbbVie S.à.r.l. | Potentiator-corrector combinations useful in the treatment of cystic fibrosis |
CA3088229A1 (en) | 2018-01-11 | 2019-07-18 | Genethon | Combination treatment of sarcoglycanopathies |
KR20210088532A (ko) | 2018-09-09 | 2021-07-14 | 카나트파마 아게 | 뇌혈관 상태를 치료하기 위한 cftr 조절제의 용도 |
KR102399037B1 (ko) * | 2020-01-06 | 2022-05-17 | 성균관대학교산학협력단 | 아민화된 아진의 신규한 제조방법 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4501750A (en) * | 1981-01-13 | 1985-02-26 | Mitsui Toatsu Kaguku Kabushiki Kaisha | Thiazole compounds, a process for preparing same and a pharmaceutical composition containing the thiazole compounds |
JPS649935A (en) | 1987-06-30 | 1989-01-13 | Kyowa Hakko Kogyo Kk | Remedy for hepatopathy |
EP0519449A1 (en) | 1991-06-21 | 1992-12-23 | Boehringer Mannheim Italia S.P.A. | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract |
US6262096B1 (en) | 1997-11-12 | 2001-07-17 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
EP1353676A4 (en) * | 2000-12-29 | 2006-05-31 | Alteon Inc | METHOD FOR THE TREATMENT OF FIBROUS OR OTHER INDICATIONS |
HN2002000156A (es) | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
SE0201837D0 (sv) | 2002-06-14 | 2002-06-14 | Astrazeneca Ab | Chemical compounds |
US7329682B2 (en) * | 2003-04-03 | 2008-02-12 | Ewha University-Industry Collaboration Foundation | Method for inhibiting 5-lipoxygenase using a benzoxazole derivative |
WO2004098510A2 (en) | 2003-04-30 | 2004-11-18 | Beth Israel Deaconess Medical Center | Cystic fibrosis therapy |
US7696244B2 (en) * | 2003-05-16 | 2010-04-13 | The Regents Of The University Of California | Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof |
-
2006
- 2006-03-08 BR BRPI0608453-2A patent/BRPI0608453A2/pt not_active Application Discontinuation
- 2006-03-08 RU RU2007138584/04A patent/RU2007138584A/ru not_active Application Discontinuation
- 2006-03-08 CA CA002600869A patent/CA2600869A1/en not_active Abandoned
- 2006-03-08 US US11/908,591 patent/US8143295B2/en active Active
- 2006-03-08 WO PCT/US2006/008267 patent/WO2006101740A2/en active Application Filing
- 2006-03-08 MX MX2007011512A patent/MX2007011512A/es not_active Application Discontinuation
- 2006-03-08 JP JP2008501913A patent/JP2008538107A/ja not_active Withdrawn
- 2006-03-08 CN CNA2006800150356A patent/CN101605543A/zh active Pending
- 2006-03-08 EP EP06737438A patent/EP1863522A4/en not_active Withdrawn
- 2006-03-08 AU AU2006227833A patent/AU2006227833A1/en not_active Abandoned
- 2006-03-08 KR KR1020077024001A patent/KR20070114820A/ko not_active Application Discontinuation
-
2007
- 2007-09-17 IL IL185999A patent/IL185999A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20080318984A1 (en) | 2008-12-25 |
AU2006227833A1 (en) | 2006-09-28 |
BRPI0608453A2 (pt) | 2009-12-29 |
CA2600869A1 (en) | 2006-09-28 |
EP1863522A4 (en) | 2010-11-10 |
WO2006101740A2 (en) | 2006-09-28 |
US8143295B2 (en) | 2012-03-27 |
JP2008538107A (ja) | 2008-10-09 |
CN101605543A (zh) | 2009-12-16 |
KR20070114820A (ko) | 2007-12-04 |
WO2006101740A3 (en) | 2009-06-04 |
EP1863522A2 (en) | 2007-12-12 |
IL185999A0 (en) | 2008-08-07 |
RU2007138584A (ru) | 2009-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |