MX2007002437A - Metodo para el sanado de heridas utilizando antagonistas del receptor de adenosina a2b. - Google Patents
Metodo para el sanado de heridas utilizando antagonistas del receptor de adenosina a2b.Info
- Publication number
- MX2007002437A MX2007002437A MX2007002437A MX2007002437A MX2007002437A MX 2007002437 A MX2007002437 A MX 2007002437A MX 2007002437 A MX2007002437 A MX 2007002437A MX 2007002437 A MX2007002437 A MX 2007002437A MX 2007002437 A MX2007002437 A MX 2007002437A
- Authority
- MX
- Mexico
- Prior art keywords
- methyl
- optionally substituted
- phenyl
- dione
- trihydro
- Prior art date
Links
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 27
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- 125000000547 substituted alkyl group Chemical group 0.000 claims description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Veterinary Medicine (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2005/030838 WO2006028810A2 (en) | 2004-09-01 | 2005-08-30 | Method of wound healing using a2b adenosine receptor antagonists |
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| RU2357969C2 (ru) | 2003-08-25 | 2009-06-10 | АДЕНОЗАЙН ТЕРАПЬЮТИКС, ЭлЭлСи | Новые замещенные 8-гетероарилксантины и фармацевтическая композиция на их основе |
| NZ589657A (en) | 2004-10-15 | 2012-06-29 | Gilead Palo Alto Inc | Method of preventing and treating airway remodeling and pulmonary inflammation using A2B adenosine receptor antagonists |
| WO2006091936A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines |
| US7579348B2 (en) * | 2005-02-25 | 2009-08-25 | Pgxhealth, Llc | Derivatives of 8-substituted xanthines |
| WO2006091898A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Pyrazolyl substituted xanthines |
| NZ564326A (en) * | 2005-06-16 | 2010-01-29 | Cv Therapeutics Inc | Prodrugs of A2B adenosine receptor antagonists |
| US7884100B2 (en) | 2006-06-16 | 2011-02-08 | Pgxhealth, Llc | Substituted 8-[6-amino-3-pyridyl]xanthines |
| US7767685B2 (en) * | 2006-06-29 | 2010-08-03 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2B receptor antagonists |
| EP2268641B1 (en) * | 2008-03-26 | 2014-09-03 | Advinus Therapeutics Pvt. Ltd. | Heterocyclic compounds as adenosine receptor antagonist |
| CA3093234A1 (en) | 2018-03-05 | 2019-09-12 | Teon Therapeutics, Inc. | Adenosine receptor antagonists and uses thereof |
| CN108864114B (zh) * | 2018-06-04 | 2020-11-06 | 应世生物科技(南京)有限公司 | 选择性a2a受体拮抗剂 |
| US20230365564A1 (en) * | 2020-09-04 | 2023-11-16 | Teon Therapeutics, Inc. | Cocrystals of an adenosine a2b receptor antagonist |
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| US4452788A (en) * | 1982-04-21 | 1984-06-05 | Warner-Lambert Company | Substituted 8-phenylxanthines |
| US4593095A (en) * | 1983-02-18 | 1986-06-03 | The Johns Hopkins University | Xanthine derivatives |
| US4558051A (en) * | 1983-10-11 | 1985-12-10 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same |
| GB8510758D0 (en) * | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
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| DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
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| US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
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-
2005
- 2005-08-30 CA CA002578702A patent/CA2578702A1/en not_active Abandoned
- 2005-08-30 PT PT05811901T patent/PT1789053E/pt unknown
- 2005-08-30 US US11/216,506 patent/US20060058322A1/en not_active Abandoned
- 2005-08-30 NZ NZ553487A patent/NZ553487A/en not_active IP Right Cessation
- 2005-08-30 WO PCT/US2005/030838 patent/WO2006028810A2/en not_active Ceased
- 2005-08-30 ES ES05811901T patent/ES2387653T3/es not_active Expired - Lifetime
- 2005-08-30 EP EP05811901A patent/EP1789053B1/en not_active Expired - Lifetime
- 2005-08-30 SI SI200531557T patent/SI1789053T1/sl unknown
- 2005-08-30 PL PL05811901T patent/PL1789053T3/pl unknown
- 2005-08-30 RS RS20120390A patent/RS52455B/sr unknown
- 2005-08-30 MX MX2007002437A patent/MX2007002437A/es active IP Right Grant
- 2005-08-30 KR KR1020077004993A patent/KR101247528B1/ko not_active Expired - Lifetime
- 2005-08-30 CN CN2005800355648A patent/CN101043889B/zh not_active Expired - Lifetime
- 2005-08-30 DK DK05811901.7T patent/DK1789053T3/da active
- 2005-08-30 JP JP2007530269A patent/JP4929173B2/ja not_active Expired - Lifetime
- 2005-08-30 AU AU2005282860A patent/AU2005282860B2/en not_active Expired
- 2005-08-30 RU RU2007107605/04A patent/RU2385322C2/ru active
- 2005-08-30 HR HRP20120712TT patent/HRP20120712T1/hr unknown
-
2007
- 2007-02-28 IL IL181634A patent/IL181634A/en active IP Right Grant
- 2007-02-28 ZA ZA200701777A patent/ZA200701777B/xx unknown
- 2007-03-30 NO NO20071718A patent/NO20071718L/no not_active Application Discontinuation
-
2011
- 2011-09-07 JP JP2011195497A patent/JP2011246492A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NZ553487A (en) | 2010-09-30 |
| RU2007107605A (ru) | 2008-09-10 |
| DK1789053T3 (da) | 2012-08-06 |
| CA2578702A1 (en) | 2006-03-16 |
| HK1107261A1 (en) | 2008-04-03 |
| JP4929173B2 (ja) | 2012-05-09 |
| IL181634A0 (en) | 2007-07-04 |
| RS52455B (sr) | 2013-02-28 |
| ES2387653T3 (es) | 2012-09-27 |
| CN101043889B (zh) | 2010-11-03 |
| WO2006028810A2 (en) | 2006-03-16 |
| US20060058322A1 (en) | 2006-03-16 |
| EP1789053A2 (en) | 2007-05-30 |
| IL181634A (en) | 2015-05-31 |
| PT1789053E (pt) | 2012-08-09 |
| AU2005282860B2 (en) | 2012-03-22 |
| CN101043889A (zh) | 2007-09-26 |
| KR101247528B1 (ko) | 2013-04-15 |
| RU2385322C2 (ru) | 2010-03-27 |
| WO2006028810A3 (en) | 2006-09-28 |
| ZA200701777B (en) | 2008-09-25 |
| SI1789053T1 (sl) | 2012-09-28 |
| HRP20120712T1 (hr) | 2012-10-31 |
| NO20071718L (no) | 2007-03-30 |
| AU2005282860A1 (en) | 2006-03-16 |
| KR20070047816A (ko) | 2007-05-07 |
| PL1789053T3 (pl) | 2012-12-31 |
| JP2008511654A (ja) | 2008-04-17 |
| JP2011246492A (ja) | 2011-12-08 |
| EP1789053B1 (en) | 2012-06-13 |
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