MX2007001052A - Nuevos derivados de indol-2-carboxamidina como antagonistas del receptor nmda. - Google Patents
Nuevos derivados de indol-2-carboxamidina como antagonistas del receptor nmda.Info
- Publication number
- MX2007001052A MX2007001052A MX2007001052A MX2007001052A MX2007001052A MX 2007001052 A MX2007001052 A MX 2007001052A MX 2007001052 A MX2007001052 A MX 2007001052A MX 2007001052 A MX2007001052 A MX 2007001052A MX 2007001052 A MX2007001052 A MX 2007001052A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- indole
- carboxamidine
- alkyl
- compounds
- Prior art date
Links
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0401523A HUP0401523A3 (en) | 2004-07-29 | 2004-07-29 | Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them |
| PCT/HU2005/000078 WO2006010965A1 (en) | 2004-07-29 | 2005-07-21 | Indole-2 -carboxamidine derivatives as nmda receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007001052A true MX2007001052A (es) | 2007-04-16 |
Family
ID=89985408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007001052A MX2007001052A (es) | 2004-07-29 | 2005-07-21 | Nuevos derivados de indol-2-carboxamidina como antagonistas del receptor nmda. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20090048303A1 (enExample) |
| EP (1) | EP1773770B1 (enExample) |
| JP (1) | JP2008508248A (enExample) |
| KR (1) | KR20070038502A (enExample) |
| CN (1) | CN1989103A (enExample) |
| AP (1) | AP2006003840A0 (enExample) |
| AT (1) | ATE427299T1 (enExample) |
| AU (1) | AU2005266160A1 (enExample) |
| BR (1) | BRPI0513932A (enExample) |
| CA (1) | CA2574155A1 (enExample) |
| DE (1) | DE602005013675D1 (enExample) |
| EA (1) | EA009981B1 (enExample) |
| GE (1) | GEP20094606B (enExample) |
| HU (1) | HUP0401523A3 (enExample) |
| IL (1) | IL179485A0 (enExample) |
| MA (1) | MA28815B1 (enExample) |
| MX (1) | MX2007001052A (enExample) |
| NO (1) | NO20071109L (enExample) |
| TN (1) | TNSN07016A1 (enExample) |
| WO (1) | WO2006010965A1 (enExample) |
| ZA (1) | ZA200700325B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| AU2011216950A1 (en) | 2010-02-16 | 2012-08-23 | Pfizer Inc. | (R)-4-((4-((4-(tetrahydrofuran-3-yloxy) benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol, a partial agonist of 5-HT4 receptors |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| CA2789440C (en) | 2010-03-10 | 2020-03-24 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| PE20140406A1 (es) * | 2010-11-18 | 2014-04-16 | Univ Yale | Moleculas bifuncionales con actividad de reclutamiento de anticuerpos y actividad inhibitoria inicial contra el virus de la inmunodeficiencia humana |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| BR112014028718A2 (pt) * | 2012-05-22 | 2017-06-27 | Autifony Therapeutics Ltd | derivados de hidantoína como inibidores de kv3 |
| JO3579B1 (ar) | 2014-09-26 | 2020-07-05 | Luc Therapeutics Inc | مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول |
| US11230541B2 (en) | 2017-07-28 | 2022-01-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9726388D0 (en) * | 1997-12-12 | 1998-02-11 | Cerebrus Ltd | Chemical compounds |
| US6376530B1 (en) * | 1999-05-10 | 2002-04-23 | Merck & Co., Inc. | Cyclic amidines useful as NMDA NR2B antagonists |
| US6319944B1 (en) * | 1999-05-10 | 2001-11-20 | Merck & Co., Inc. | Aryl amidines, compositions containing such compounds and methods of use |
| GB0015488D0 (en) * | 2000-06-23 | 2000-08-16 | Merck Sharp & Dohme | Therapeutic agents |
| HU227197B1 (en) * | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| JP2004253425A (ja) * | 2003-02-18 | 2004-09-09 | Tdk Corp | 積層コンデンサ |
-
2004
- 2004-07-29 HU HU0401523A patent/HUP0401523A3/hu unknown
-
2005
- 2005-07-21 EP EP05764412A patent/EP1773770B1/en not_active Expired - Lifetime
- 2005-07-21 KR KR1020077000263A patent/KR20070038502A/ko not_active Withdrawn
- 2005-07-21 US US11/658,787 patent/US20090048303A1/en not_active Abandoned
- 2005-07-21 AP AP2006003840A patent/AP2006003840A0/xx unknown
- 2005-07-21 MX MX2007001052A patent/MX2007001052A/es active IP Right Grant
- 2005-07-21 AT AT05764412T patent/ATE427299T1/de not_active IP Right Cessation
- 2005-07-21 EA EA200700365A patent/EA009981B1/ru not_active IP Right Cessation
- 2005-07-21 CN CNA2005800247658A patent/CN1989103A/zh active Pending
- 2005-07-21 GE GEAP20059893A patent/GEP20094606B/en unknown
- 2005-07-21 WO PCT/HU2005/000078 patent/WO2006010965A1/en not_active Ceased
- 2005-07-21 AU AU2005266160A patent/AU2005266160A1/en not_active Abandoned
- 2005-07-21 DE DE602005013675T patent/DE602005013675D1/de not_active Expired - Fee Related
- 2005-07-21 BR BRPI0513932-5A patent/BRPI0513932A/pt not_active IP Right Cessation
- 2005-07-21 CA CA002574155A patent/CA2574155A1/en not_active Abandoned
- 2005-07-21 JP JP2007523161A patent/JP2008508248A/ja not_active Withdrawn
-
2006
- 2006-11-22 IL IL179485A patent/IL179485A0/en unknown
-
2007
- 2007-01-11 ZA ZA200700325A patent/ZA200700325B/en unknown
- 2007-01-17 TN TNP2007000016A patent/TNSN07016A1/en unknown
- 2007-02-22 MA MA29702A patent/MA28815B1/fr unknown
- 2007-02-27 NO NO20071109A patent/NO20071109L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005013675D1 (de) | 2009-05-14 |
| EP1773770A1 (en) | 2007-04-18 |
| BRPI0513932A (pt) | 2008-05-20 |
| TNSN07016A1 (en) | 2008-06-02 |
| AU2005266160A1 (en) | 2006-02-02 |
| US20090048303A1 (en) | 2009-02-19 |
| HU0401523D0 (en) | 2004-09-28 |
| EP1773770B1 (en) | 2009-04-01 |
| HUP0401523A2 (en) | 2006-11-28 |
| KR20070038502A (ko) | 2007-04-10 |
| MA28815B1 (fr) | 2007-08-01 |
| CN1989103A (zh) | 2007-06-27 |
| CA2574155A1 (en) | 2006-02-02 |
| IL179485A0 (en) | 2007-05-15 |
| AP2006003840A0 (en) | 2006-12-31 |
| HUP0401523A3 (en) | 2007-05-02 |
| ATE427299T1 (de) | 2009-04-15 |
| WO2006010965A1 (en) | 2006-02-02 |
| EA200700365A1 (ru) | 2007-06-29 |
| GEP20094606B (en) | 2009-02-10 |
| NO20071109L (no) | 2007-02-27 |
| EA009981B1 (ru) | 2008-04-28 |
| JP2008508248A (ja) | 2008-03-21 |
| ZA200700325B (en) | 2008-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |