HUP0401523A3 - Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them - Google Patents

Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them

Info

Publication number
HUP0401523A3
HUP0401523A3 HU0401523A HUP0401523A HUP0401523A3 HU P0401523 A3 HUP0401523 A3 HU P0401523A3 HU 0401523 A HU0401523 A HU 0401523A HU P0401523 A HUP0401523 A HU P0401523A HU P0401523 A3 HUP0401523 A3 HU P0401523A3
Authority
HU
Hungary
Prior art keywords
indole
producing
pharmaceutical compositions
compositions containing
carboxamide derivatives
Prior art date
Application number
HU0401523A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Priority to HU0401523A priority Critical patent/HUP0401523A3/hu
Publication of HU0401523D0 publication Critical patent/HU0401523D0/hu
Priority to EP05764412A priority patent/EP1773770B1/en
Priority to US11/658,787 priority patent/US20090048303A1/en
Priority to EA200700365A priority patent/EA009981B1/ru
Priority to PCT/HU2005/000078 priority patent/WO2006010965A1/en
Priority to GEAP20059893A priority patent/GEP20094606B/en
Priority to AT05764412T priority patent/ATE427299T1/de
Priority to MX2007001052A priority patent/MX2007001052A/es
Priority to AP2006003840A priority patent/AP2006003840A0/xx
Priority to AU2005266160A priority patent/AU2005266160A1/en
Priority to BRPI0513932-5A priority patent/BRPI0513932A/pt
Priority to DE602005013675T priority patent/DE602005013675D1/de
Priority to KR1020077000263A priority patent/KR20070038502A/ko
Priority to JP2007523161A priority patent/JP2008508248A/ja
Priority to CA002574155A priority patent/CA2574155A1/en
Priority to CNA2005800247658A priority patent/CN1989103A/zh
Priority to IL179485A priority patent/IL179485A0/en
Publication of HUP0401523A2 publication Critical patent/HUP0401523A2/hu
Priority to ZA200700325A priority patent/ZA200700325B/en
Priority to TNP2007000016A priority patent/TNSN07016A1/en
Priority to MA29702A priority patent/MA28815B1/fr
Priority to NO20071109A priority patent/NO20071109L/no
Publication of HUP0401523A3 publication Critical patent/HUP0401523A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
HU0401523A 2004-07-29 2004-07-29 Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them HUP0401523A3 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
HU0401523A HUP0401523A3 (en) 2004-07-29 2004-07-29 Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them
CNA2005800247658A CN1989103A (zh) 2004-07-29 2005-07-21 作为nmda受体拮抗剂的吲哚－2－甲脒衍生物
BRPI0513932-5A BRPI0513932A (pt) 2004-07-29 2005-07-21 derivados de indol-2-carboxamidina como antagonistas de receptores de nmda
KR1020077000263A KR20070038502A (ko) 2004-07-29 2005-07-21 Ｎｍｄａ 수용체 길항물질인 인돌-2-카르복사미딘 유도체
EA200700365A EA009981B1 (ru) 2004-07-29 2005-07-21 Производные индол-2-карбоксамидина как антагонисты nmda рецептора
PCT/HU2005/000078 WO2006010965A1 (en) 2004-07-29 2005-07-21 Indole-2 -carboxamidine derivatives as nmda receptor antagonists
GEAP20059893A GEP20094606B (en) 2004-07-29 2005-07-21 Indole-2 -carboxamidine derivatives as nmda receptor antagonists
AT05764412T ATE427299T1 (de) 2004-07-29 2005-07-21 Indol-2-carboxamidin-derivate als antagonisten der nmda-rezeptoren
MX2007001052A MX2007001052A (es) 2004-07-29 2005-07-21 Nuevos derivados de indol-2-carboxamidina como antagonistas del receptor nmda.
AP2006003840A AP2006003840A0 (en) 2004-07-29 2005-07-21 Indole-2-carboxamidine derivatives as NMDA receptor antagonists
AU2005266160A AU2005266160A1 (en) 2004-07-29 2005-07-21 Indole-2 -carboxamidine derivatives as NMDA receptor antagonists
EP05764412A EP1773770B1 (en) 2004-07-29 2005-07-21 Indole-2-carboxamidine derivatives as nmda receptor antagonists
DE602005013675T DE602005013675D1 (de) 2004-07-29 2005-07-21 Indol-2-carboxamidin-derivate als antagonisten der nmda-rezeptoren
US11/658,787 US20090048303A1 (en) 2004-07-29 2005-07-21 Indole-2-carboxamidine derivatives as nmda receptor antago
JP2007523161A JP2008508248A (ja) 2004-07-29 2005-07-21 Ｎｍｄａ受容体アンタゴニストとしてのインドール−２−カルボキサミジン誘導体
CA002574155A CA2574155A1 (en) 2004-07-29 2005-07-21 Indole-2 -carboxamidine derivatives as nmda receptor antagonists
IL179485A IL179485A0 (en) 2004-07-29 2006-11-22 Indole-2 carboxamidine derivatives as nmda receptor antagonists
ZA200700325A ZA200700325B (en) 2004-07-29 2007-01-11 Indole-2-carboxamidine derivatives as NMDA receptor antagonists
TNP2007000016A TNSN07016A1 (en) 2004-07-29 2007-01-17 Indole-2-carboxamidine derivatives as nmda receptor antagonists
MA29702A MA28815B1 (fr) 2004-07-29 2007-02-22 Derives de indole-2-carboxamidine utilises comme antagonistes du recepteur nmda
NO20071109A NO20071109L (no) 2004-07-29 2007-02-27 Indol-2-karboksamidinderivater som NMDA-reseptorantagonister

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0401523A HUP0401523A3 (en) 2004-07-29 2004-07-29 Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them

Publications (3)

Publication Number Publication Date
HU0401523D0 HU0401523D0 (en) 2004-09-28
HUP0401523A2 HUP0401523A2 (en) 2006-11-28
HUP0401523A3 true HUP0401523A3 (en) 2007-05-02

Family

ID=89985408

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401523A HUP0401523A3 (en) 2004-07-29 2004-07-29 Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them

Country Status (21)

Country Link
US (1) US20090048303A1 (enExample)
EP (1) EP1773770B1 (enExample)
JP (1) JP2008508248A (enExample)
KR (1) KR20070038502A (enExample)
CN (1) CN1989103A (enExample)
AP (1) AP2006003840A0 (enExample)
AT (1) ATE427299T1 (enExample)
AU (1) AU2005266160A1 (enExample)
BR (1) BRPI0513932A (enExample)
CA (1) CA2574155A1 (enExample)
DE (1) DE602005013675D1 (enExample)
EA (1) EA009981B1 (enExample)
GE (1) GEP20094606B (enExample)
HU (1) HUP0401523A3 (enExample)
IL (1) IL179485A0 (enExample)
MA (1) MA28815B1 (enExample)
MX (1) MX2007001052A (enExample)
NO (1) NO20071109L (enExample)
TN (1) TNSN07016A1 (enExample)
WO (1) WO2006010965A1 (enExample)
ZA (1) ZA200700325B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
KR20120123089A (ko) 2010-02-16 2012-11-07 화이자 인코포레이티드 5-ＨＴ₄ 수용체의 부분 효능제인 (Ｒ)-4-((4-((4-(테트라히드로푸란-3-일옥시)벤조［ｄ］이속사졸-3-일옥시)메틸)피페리딘-1-일)메틸)테트라히드로-2Ｈ-피란-4-올
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
MX2012010470A (es) 2010-03-10 2012-10-09 Probiodrug Ag Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
CA2818308A1 (en) * 2010-11-18 2012-05-24 Yale University Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
JP2015517563A (ja) * 2012-05-22 2015-06-22 アウトイフオンイ トヘラペウトイクス リミテッド Ｋｖ３阻害剤としてのヒダントイン誘導体
JO3579B1 (ar) 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
US11230541B2 (en) 2017-07-28 2022-01-25 Takeda Pharmaceutical Company Limited Heterocyclic compound
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
US12637418B2 (en) 2019-01-24 2026-05-26 Takeda Pharmaceutical Company Limited Heterocyclic compounds as antagonist of NMDA
JP2021050161A (ja) 2019-09-25 2021-04-01 武田薬品工業株式会社 複素環化合物及びその用途
JP2021080177A (ja) 2019-11-14 2021-05-27 武田薬品工業株式会社 複素環化合物及びその用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9726388D0 (en) * 1997-12-12 1998-02-11 Cerebrus Ltd Chemical compounds
US6376530B1 (en) * 1999-05-10 2002-04-23 Merck & Co., Inc. Cyclic amidines useful as NMDA NR2B antagonists
US6319944B1 (en) * 1999-05-10 2001-11-20 Merck & Co., Inc. Aryl amidines, compositions containing such compounds and methods of use
GB0015488D0 (en) * 2000-06-23 2000-08-16 Merck Sharp & Dohme Therapeutic agents
HU227197B1 (en) * 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
JP2004253425A (ja) * 2003-02-18 2004-09-09 Tdk Corp 積層コンデンサ

Also Published As

Publication number Publication date
DE602005013675D1 (de) 2009-05-14
TNSN07016A1 (en) 2008-06-02
KR20070038502A (ko) 2007-04-10
AP2006003840A0 (en) 2006-12-31
JP2008508248A (ja) 2008-03-21
WO2006010965A1 (en) 2006-02-02
NO20071109L (no) 2007-02-27
US20090048303A1 (en) 2009-02-19
MX2007001052A (es) 2007-04-16
ZA200700325B (en) 2008-05-28
CN1989103A (zh) 2007-06-27
CA2574155A1 (en) 2006-02-02
AU2005266160A1 (en) 2006-02-02
MA28815B1 (fr) 2007-08-01
BRPI0513932A (pt) 2008-05-20
HU0401523D0 (en) 2004-09-28
EP1773770A1 (en) 2007-04-18
EA200700365A1 (ru) 2007-06-29
ATE427299T1 (de) 2009-04-15
GEP20094606B (en) 2009-02-10
EA009981B1 (ru) 2008-04-28
EP1773770B1 (en) 2009-04-01
IL179485A0 (en) 2007-05-15
HUP0401523A2 (en) 2006-11-28

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