MX19785A - Acidos aminoalcandifosfonicos n-substituidos y procedimiento para su preparacion. - Google Patents

Acidos aminoalcandifosfonicos n-substituidos y procedimiento para su preparacion.

Info

Publication number
MX19785A
MX19785A MX19785A MX1978590A MX19785A MX 19785 A MX19785 A MX 19785A MX 19785 A MX19785 A MX 19785A MX 1978590 A MX1978590 A MX 1978590A MX 19785 A MX19785 A MX 19785A
Authority
MX
Mexico
Prior art keywords
aminoalcandifosphonic
acids
substituted
preparation procedure
formula
Prior art date
Application number
MX19785A
Other languages
English (en)
Inventor
Knut A Jaeggi
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of MX19785A publication Critical patent/MX19785A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)

Abstract

6Los compuestos de la fórmula (I) y las sales de los mismos, por tanto, son excelentemente apropiados para usarse como compuestos activos para el tratamiento de enfermedades que pueden ser asociadas con las alteraciones del metabolismo de calcio por ejemplo los procedimientos inflamatorios en los procedimientos degenerativos de las articulaciones en cartílago articular, osteoporosis, periodontitis, hiperparatiroidismo y los depósitos de calcio en los vasos sanguíneos o en los implantes prostéticos.
MX19785A 1989-03-08 1990-03-06 Acidos aminoalcandifosfonicos n-substituidos y procedimiento para su preparacion. MX19785A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH86689 1989-03-08

Publications (1)

Publication Number Publication Date
MX19785A true MX19785A (es) 1994-03-31

Family

ID=4197009

Family Applications (1)

Application Number Title Priority Date Filing Date
MX19785A MX19785A (es) 1989-03-08 1990-03-06 Acidos aminoalcandifosfonicos n-substituidos y procedimiento para su preparacion.

Country Status (21)

Country Link
US (1) US5036058A (es)
EP (1) EP0387194B1 (es)
JP (1) JPH02279689A (es)
KR (1) KR900014413A (es)
AT (1) ATE117308T1 (es)
AU (1) AU629298B2 (es)
CA (1) CA2011586A1 (es)
DD (1) DD297824A5 (es)
DE (1) DE59008275D1 (es)
DK (1) DK0387194T3 (es)
ES (1) ES2067010T3 (es)
FI (1) FI95264C (es)
HU (1) HU206120B (es)
IE (1) IE64984B1 (es)
IL (1) IL93586A (es)
MX (1) MX19785A (es)
NO (1) NO174152C (es)
NZ (1) NZ232805A (es)
PH (1) PH26923A (es)
PT (1) PT93353B (es)
ZA (1) ZA901742B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4015715A1 (de) * 1990-05-16 1991-11-21 Bayer Ag Neuartige oligophosphate mit antiviraler wirkung
IE912115A1 (en) * 1990-06-25 1992-01-01 Takeda Chemical Industries Ltd Bisphosphonic acid derivatives, their production and use
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
ATE133677T1 (de) * 1990-12-19 1996-02-15 Takeda Chemical Industries Ltd Bisphosphonsäurederivate, ihre produktion und ihre verwendung
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
EP0531253B1 (en) * 1991-08-27 1997-01-08 Ciba-Geigy Ag N-substituted aminomethanediphosphonic acids
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5283057A (en) * 1992-04-24 1994-02-01 The Procter & Gamble Company Risedronate in oral compositions
JP2006176499A (ja) * 2004-11-25 2006-07-06 Nippon Seibutsu Seizai:Kk 眼疾患治療剤
FR2926081B1 (fr) * 2008-01-03 2010-02-19 Univ Nantes Derives d'acide hydroxy-bisphosphonique comme vecteur ciblant le tissu osseux
FR2973378B1 (fr) * 2011-03-28 2013-10-04 Atlanthera Derives d'acide hydroxybisphosphonique bifonctionnels

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
GB8419489D0 (en) * 1984-07-31 1984-09-05 Leo Pharm Prod Ltd Chemical compounds
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
IT1187828B (it) * 1985-05-24 1987-12-23 Gentili Ist Spa Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
EP0243173B1 (en) * 1986-04-24 1991-06-26 Fujisawa Pharmaceutical Co., Ltd. New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
GB8618259D0 (en) * 1986-07-25 1986-09-03 Leo Pharm Prod Ltd Pharmaceutical compositions
ATE64397T1 (de) * 1986-11-21 1991-06-15 Ciba Geigy Ag Aromatisch substituierte azacycloalkylalkandiphosphons|uren.
US4933472A (en) * 1988-04-08 1990-06-12 Yamanouchi Pharmaceutical Co., Ltd. Substituted aminomethylenebis(phosphonic acid) derivatives

Also Published As

Publication number Publication date
NO174152C (no) 1994-03-23
IE64984B1 (en) 1995-09-20
ES2067010T3 (es) 1995-03-16
NZ232805A (en) 1992-06-25
PT93353A (pt) 1990-11-07
JPH02279689A (ja) 1990-11-15
KR900014413A (ko) 1990-10-23
DD297824A5 (de) 1992-01-23
AU629298B2 (en) 1992-10-01
NO901077L (no) 1990-09-10
AU4988490A (en) 1990-09-13
PT93353B (pt) 1996-02-29
EP0387194B1 (de) 1995-01-18
US5036058A (en) 1991-07-30
HUT53112A (en) 1990-09-28
ATE117308T1 (de) 1995-02-15
PH26923A (en) 1992-12-03
ZA901742B (en) 1990-10-31
DK0387194T3 (da) 1995-03-20
HU206120B (en) 1992-08-28
NO174152B (no) 1993-12-13
CA2011586A1 (en) 1990-09-08
NO901077D0 (no) 1990-03-07
FI95264B (fi) 1995-09-29
HU901348D0 (en) 1990-05-28
EP0387194A1 (de) 1990-09-12
IE900809L (en) 1990-09-08
IL93586A0 (en) 1990-12-23
FI901103A0 (fi) 1990-03-05
DE59008275D1 (de) 1995-03-02
FI95264C (fi) 1996-01-10
IL93586A (en) 1995-06-29

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