ME01719B - Inhibitori cxcr1/2 kao adjuvansi u transplantaciji pankreasnih ostrvaca - Google Patents
Inhibitori cxcr1/2 kao adjuvansi u transplantaciji pankreasnih ostrvacaInfo
- Publication number
- ME01719B ME01719B MEP-2014-24A MEP2414A ME01719B ME 01719 B ME01719 B ME 01719B ME P2414 A MEP2414 A ME P2414A ME 01719 B ME01719 B ME 01719B
- Authority
- ME
- Montenegro
- Prior art keywords
- inhibitor
- pancreatic islet
- cxcr1
- medicament
- inhibitor according
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims 10
- 210000004153 islets of langerhan Anatomy 0.000 title claims 5
- 239000002671 adjuvant Substances 0.000 title claims 2
- 239000003814 drug Substances 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- -1 4-isobutylphenyl Chemical group 0.000 claims 1
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 claims 1
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims 1
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 claims 1
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172364A EP2308484A1 (en) | 2009-10-06 | 2009-10-06 | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| EP10761018.0A EP2485723B1 (en) | 2009-10-06 | 2010-10-06 | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| PCT/EP2010/064921 WO2011042466A1 (en) | 2009-10-06 | 2010-10-06 | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01719B true ME01719B (me) | 2014-09-20 |
Family
ID=41818891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2014-24A ME01719B (me) | 2009-10-06 | 2010-10-06 | Inhibitori cxcr1/2 kao adjuvansi u transplantaciji pankreasnih ostrvaca |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20120202884A1 (enExample) |
| EP (2) | EP2308484A1 (enExample) |
| JP (2) | JP5834010B2 (enExample) |
| KR (2) | KR101817912B1 (enExample) |
| CN (2) | CN104906572A (enExample) |
| AU (1) | AU2010305385B2 (enExample) |
| BR (1) | BR112012007991B8 (enExample) |
| CA (1) | CA2775902C (enExample) |
| CY (1) | CY1115018T1 (enExample) |
| DK (1) | DK2485723T3 (enExample) |
| EA (1) | EA021298B1 (enExample) |
| ES (1) | ES2451349T3 (enExample) |
| HK (1) | HK1213777A1 (enExample) |
| HR (1) | HRP20140202T1 (enExample) |
| IL (1) | IL219037A (enExample) |
| ME (1) | ME01719B (enExample) |
| MX (1) | MX2012004082A (enExample) |
| NZ (1) | NZ599172A (enExample) |
| PL (1) | PL2485723T3 (enExample) |
| PT (1) | PT2485723E (enExample) |
| RS (1) | RS53249B (enExample) |
| SI (1) | SI2485723T1 (enExample) |
| SM (1) | SMT201400033B (enExample) |
| WO (1) | WO2011042466A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2308485A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| EP2308484A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| CN103159652B (zh) * | 2011-12-19 | 2016-06-08 | 天津市国际生物医药联合研究院 | 亚磺酰胺类化合物的制备及其应用 |
| CN105722972A (zh) | 2013-06-18 | 2016-06-29 | 纽约大学 | 参与金黄色葡萄球菌杀白细胞素的细胞毒性的细胞因素：新型治疗靶点 |
| CN109890364B (zh) | 2016-10-03 | 2023-10-17 | 儿童医疗中心公司 | 糖尿病肾病的预防和治疗 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1303249B1 (it) | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
| US20020042370A1 (en) * | 2000-04-14 | 2002-04-11 | Millennium Pharmaceuticals, Inc. | Method of treating graft rejection using inhibitors of CCR2 function |
| WO2001078708A1 (en) * | 2000-04-14 | 2001-10-25 | Millennium Pharmaceuticals, Inc. | Treating graft rejection with cxcr3 inhibitors |
| ITMI20010206A1 (it) | 2001-02-02 | 2002-08-02 | Dompe Spa | Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz |
| PT1776336E (pt) * | 2004-03-23 | 2009-12-18 | Dompe Spa | Derivados de ácido 2-fenilpropiónico e composições farmacêuticas que os contêm |
| EP1579859B1 (en) | 2004-03-25 | 2006-12-13 | DOMPE' pha.r.ma s.p.a. | Use of N-(2-aryl-propionyl)-sulfonamides for the treatment of spinal cord injury |
| US20050261762A1 (en) * | 2004-05-21 | 2005-11-24 | Medtronic Vascular, Inc. | Medical devices to prevent or inhibit restenosis |
| TWI400232B (zh) * | 2004-09-13 | 2013-07-01 | Ono Pharmaceutical Co | 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑 |
| JP5232144B2 (ja) * | 2006-06-28 | 2013-07-10 | サノフイ | Ｃｘｃｒ２阻害剤 |
| JP2010504996A (ja) * | 2006-09-26 | 2010-02-18 | ケース ウエスタン リザーブ ユニバーシティ | サイトカインシグナリング |
| WO2009117706A2 (en) | 2008-03-20 | 2009-09-24 | Carolus Therapeutics, Inc. | Methods of treatment using anti-mif antibodies |
| EP2308484A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
-
2009
- 2009-10-06 EP EP09172364A patent/EP2308484A1/en not_active Withdrawn
-
2010
- 2010-10-06 ME MEP-2014-24A patent/ME01719B/me unknown
- 2010-10-06 DK DK10761018.0T patent/DK2485723T3/en active
- 2010-10-06 KR KR1020177015626A patent/KR101817912B1/ko not_active Expired - Fee Related
- 2010-10-06 EA EA201270513A patent/EA021298B1/ru unknown
- 2010-10-06 CN CN201510089937.5A patent/CN104906572A/zh active Pending
- 2010-10-06 HR HRP20140202AT patent/HRP20140202T1/hr unknown
- 2010-10-06 JP JP2012532579A patent/JP5834010B2/ja not_active Expired - Fee Related
- 2010-10-06 RS RS20140102A patent/RS53249B/sr unknown
- 2010-10-06 MX MX2012004082A patent/MX2012004082A/es active IP Right Grant
- 2010-10-06 PT PT107610180T patent/PT2485723E/pt unknown
- 2010-10-06 CN CN201080045208.5A patent/CN102665703B/zh not_active Expired - Fee Related
- 2010-10-06 ES ES10761018.0T patent/ES2451349T3/es active Active
- 2010-10-06 AU AU2010305385A patent/AU2010305385B2/en not_active Ceased
- 2010-10-06 CA CA2775902A patent/CA2775902C/en not_active Expired - Fee Related
- 2010-10-06 KR KR1020127010732A patent/KR101759362B1/ko not_active Expired - Fee Related
- 2010-10-06 US US13/500,544 patent/US20120202884A1/en not_active Abandoned
- 2010-10-06 PL PL10761018T patent/PL2485723T3/pl unknown
- 2010-10-06 SI SI201030553T patent/SI2485723T1/sl unknown
- 2010-10-06 WO PCT/EP2010/064921 patent/WO2011042466A1/en not_active Ceased
- 2010-10-06 NZ NZ599172A patent/NZ599172A/en not_active IP Right Cessation
- 2010-10-06 EP EP10761018.0A patent/EP2485723B1/en active Active
- 2010-10-06 BR BR112012007991A patent/BR112012007991B8/pt not_active IP Right Cessation
-
2012
- 2012-04-04 IL IL219037A patent/IL219037A/en active IP Right Grant
-
2014
- 2014-03-07 CY CY20141100185T patent/CY1115018T1/el unknown
- 2014-03-19 SM SM201400033T patent/SMT201400033B/xx unknown
-
2015
- 2015-04-06 JP JP2015077750A patent/JP6097328B2/ja not_active Expired - Fee Related
-
2016
- 2016-02-18 HK HK16101720.7A patent/HK1213777A1/zh unknown
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