MD87C2 - The process for obtaining the N-[2-(4-fluorphenyl)-1 methyl]-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts. - Google Patents
The process for obtaining the N-[2-(4-fluorphenyl)-1 methyl]-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts.Info
- Publication number
- MD87C2 MD87C2 MD94-0136A MD940136A MD87C2 MD 87 C2 MD87 C2 MD 87C2 MD 940136 A MD940136 A MD 940136A MD 87 C2 MD87 C2 MD 87C2
- Authority
- MD
- Moldova
- Prior art keywords
- obtaining
- isomer
- methyl
- product
- propynylamine
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to the amines, in particular to the obtaining process of theN-[2-(4-fluorphenyl)-1 methyl]-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts, having the antideprisive action and inhibiting absorbing biogenesis amines, which could be used in medicine. The purpose of the invention consists in creation of a new more active compound of this group. The synthesis was happening in the reaction results of the derivative phenyl isopropyl of general formula:X - CH(CH3)-CH2-C=CH-CH=CY-CH=CH,in which X is haloid, tozylate, Y-is fluor, NO2 with amine of general formula HNR1R2, in which R1 is CH2-C-CH, hydrogen; R2 is fluor, methyl.If R1 is H, the obtaining product was treated with HCşC-CH2şBr, if Y-is NO2, product was reduced and then the obtaining derivative amine is diazotize in the medium of the fluoboric acid with the following degradation of fluoborate diazonium with cupric chloride.The special product is evolved in racement form, L-isomer or his salt. The components was selective inhibiting of the MAO-B type (tyraminase ferment) inhibited the catecholamine and secondary action absorbtion of the monoamines (for example tyramines) and neurons protection from the toxin and selective acting endogenous (6-OHDA) and exogenous (MTPT) with LD50ş60-64 mg/kg toxicity.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU842124A HU207282B (en) | 1984-05-31 | 1984-05-31 | Process for producing phenyl-alkyl-amine derivatives and pharmaceutical compositions containing them |
PCT/HU1985/000035 WO1985005617A1 (en) | 1984-05-31 | 1985-05-31 | Phenylisopropylamine derivative and its preparation |
SU864015073A SU1487810A3 (en) | 1984-05-31 | 1986-01-30 | Method of producing n-/2-(4-fluorophenyl))-1-methyl/-ethyl-n-methyl-n-propylniamine |
SU864027666A SU1549477A3 (en) | 1984-05-31 | 1986-06-16 | Method of producing n-/2-(4-fluorophenyl)-1-methyl/ethyl-n-methyl-n-propynylamine as racemate or its l-isomer or its salts |
Publications (2)
Publication Number | Publication Date |
---|---|
MD87B1 MD87B1 (en) | 1994-11-30 |
MD87C2 true MD87C2 (en) | 1995-03-31 |
Family
ID=27269988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD94-0136A MD87C2 (en) | 1984-05-31 | 1985-05-31 | The process for obtaining the N-[2-(4-fluorphenyl)-1 methyl]-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts. |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD87C2 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3485874A (en) * | 1966-05-04 | 1969-12-23 | Chinoin Gyogyszer Es Vegyeszet | Ortho and para bromophenyl isopropyl methylamines |
CH524568A (en) * | 1965-02-08 | 1972-06-30 | Chinoin Gyogyszer Es Vegyeszet | N-(Lower alkyl)-phenylisopropylamines |
-
1985
- 1985-05-31 MD MD94-0136A patent/MD87C2/en active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH524568A (en) * | 1965-02-08 | 1972-06-30 | Chinoin Gyogyszer Es Vegyeszet | N-(Lower alkyl)-phenylisopropylamines |
US3485874A (en) * | 1966-05-04 | 1969-12-23 | Chinoin Gyogyszer Es Vegyeszet | Ortho and para bromophenyl isopropyl methylamines |
Also Published As
Publication number | Publication date |
---|---|
MD87B1 (en) | 1994-11-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Hibasami et al. | Dicyclohexylamine, a potent inhibitor of spermidine synthase in mammalian cells | |
ATE20467T1 (en) | TROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR MANUFACTURE, AND THEIR PHARMACEUTICAL COMPOSITIONS. | |
PT94925A (en) | METHOD FOR THE PREPARATION OF TIAZOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
CA1273019C (en) | Enkephalinase inhibitors | |
ES8401941A1 (en) | Spiro-(4,(3+n))-2-aza-alkan-3-carboxylic-acid derivatives, process for their preparation,agents containing them and their use. | |
ES420209A1 (en) | Certain 4-amino-6-aryl-pyrimidines | |
NZ333550A (en) | Matrix metalloproteinase inhibitors for inhibiting the release of TNF | |
DE69632854D1 (en) | ACTIVE SUBSTANCE TO PROTECT ORGANIC OR TISSUE | |
ATE59033T1 (en) | N-CONTAINING HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM. | |
ES8800658A1 (en) | PROCEDURE FOR THE SYNTHESIS OF OMEGAAMINATED ACID DERIVATIVES (Machine-translation by Google Translate, not legally binding) | |
GB1036280A (en) | Imidazolidine derivatives and a process for the manufacture thereof | |
MD87C2 (en) | The process for obtaining the N-[2-(4-fluorphenyl)-1 methyl]-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts. | |
RU96101800A (en) | AMIDA DERIVATIVES OF PHENYLCYCLOGAXYLICARBONIC ACID, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERES AND THEIR SALT, PHARMACEUTICAL COMPOSITION WITH ANTI-ARTERIOCLEROTIC AND ANTI-RETENCY | |
ES381534A2 (en) | A procedure for the preparation of new derivatives of 1-phenyl-2-aminoetanol. (Machine-translation by Google Translate, not legally binding) | |
GB1168080A (en) | New N-Propynyl Methylamines and their Salts, and process for preparation thereof | |
ATE153500T1 (en) | METHOD FOR INHIBITING FIBROSIS | |
ES8500899A1 (en) | Mercaptoacetic acid and 3-mercaptopropionic acid amide derivatives for use in treatment of a human or animal body, some new derivatives and pharmaceutical compositions containing them. | |
ES446126A1 (en) | 2-(phenoxyalkylthio)imidazoles and congeners | |
Smissman et al. | Specificity in enzyme inhibition. 3. Synthesis of 5-substituted-2, 2-dimethyl-4-imidazolidinones as inhibitors of tyrosine decarboxylase and histidine decarboxylase | |
GB1090252A (en) | Dibenzothiazine derivatives | |
RU94044457A (en) | Use of benzthiophenes for hirsutism and alopecia inhibition | |
GB1438268A (en) | Antidepressant | |
IL69448A (en) | Process for combating phytopathogenic fungi with azolylphenoxy-tetrahydrofuran-2-ylidene methane derivatives | |
MD88C2 (en) | The process for obtaining the the N-(2-(4-fluorphenyl)-1 methyl)-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts. | |
JPS5731616A (en) | Relaxing agent for muscle comprising benzofurancarboxylic acid amide |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20050530 |