MD87C2 - The process for obtaining the N-[2-(4-fluorphenyl)-1 methyl]-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts. - Google Patents

The process for obtaining the N-[2-(4-fluorphenyl)-1 methyl]-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts.

Info

Publication number
MD87C2
MD87C2 MD94-0136A MD940136A MD87C2 MD 87 C2 MD87 C2 MD 87C2 MD 940136 A MD940136 A MD 940136A MD 87 C2 MD87 C2 MD 87C2
Authority
MD
Moldova
Prior art keywords
obtaining
isomer
methyl
product
propynylamine
Prior art date
Application number
MD94-0136A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD87B1 (en
Inventor
Zoltan Ecsery
Jozsef Knoll
Eva Somfai
Torok Zoltan
Eva Szinnyei
Karoly Moszolits
Original Assignee
Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU842124A external-priority patent/HU207282B/en
Application filed by Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt.
Publication of MD87B1 publication Critical patent/MD87B1/en
Publication of MD87C2 publication Critical patent/MD87C2/en

Links

Abstract

The invention relates to the amines, in particular to the obtaining process of theN-[2-(4-fluorphenyl)-1 methyl]-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts, having the antideprisive action and inhibiting absorbing biogenesis amines, which could be used in medicine. The purpose of the invention consists in creation of a new more active compound of this group. The synthesis was happening in the reaction results of the derivative phenyl isopropyl of general formula:X - CH(CH3)-CH2-C=CH-CH=CY-CH=CH,in which X is haloid, tozylate, Y-is fluor, NO2 with amine of general formula HNR1R2, in which R1 is CH2-C-CH, hydrogen; R2 is fluor, methyl.If R1 is H, the obtaining product was treated with HCşC-CH2şBr, if Y-is NO2, product was reduced and then the obtaining derivative amine is diazotize in the medium of the fluoboric acid with the following degradation of fluoborate diazonium with cupric chloride.The special product is evolved in racement form, L-isomer or his salt. The components was selective inhibiting of the MAO-B type (tyraminase ferment) inhibited the catecholamine and secondary action absorbtion of the monoamines (for example tyramines) and neurons protection from the toxin and selective acting endogenous (6-OHDA) and exogenous (MTPT) with LD50ş60-64 mg/kg toxicity.
MD94-0136A 1984-05-31 1985-05-31 The process for obtaining the N-[2-(4-fluorphenyl)-1 methyl]-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts. MD87C2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU842124A HU207282B (en) 1984-05-31 1984-05-31 Process for producing phenyl-alkyl-amine derivatives and pharmaceutical compositions containing them
PCT/HU1985/000035 WO1985005617A1 (en) 1984-05-31 1985-05-31 Phenylisopropylamine derivative and its preparation
SU864015073A SU1487810A3 (en) 1984-05-31 1986-01-30 Method of producing n-/2-(4-fluorophenyl))-1-methyl/-ethyl-n-methyl-n-propylniamine
SU864027666A SU1549477A3 (en) 1984-05-31 1986-06-16 Method of producing n-/2-(4-fluorophenyl)-1-methyl/ethyl-n-methyl-n-propynylamine as racemate or its l-isomer or its salts

Publications (2)

Publication Number Publication Date
MD87B1 MD87B1 (en) 1994-11-30
MD87C2 true MD87C2 (en) 1995-03-31

Family

ID=27269988

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0136A MD87C2 (en) 1984-05-31 1985-05-31 The process for obtaining the N-[2-(4-fluorphenyl)-1 methyl]-ethyl-N-propynylamine in kind of racemate or his L-isomer, and his salts.

Country Status (1)

Country Link
MD (1) MD87C2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485874A (en) * 1966-05-04 1969-12-23 Chinoin Gyogyszer Es Vegyeszet Ortho and para bromophenyl isopropyl methylamines
CH524568A (en) * 1965-02-08 1972-06-30 Chinoin Gyogyszer Es Vegyeszet N-(Lower alkyl)-phenylisopropylamines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH524568A (en) * 1965-02-08 1972-06-30 Chinoin Gyogyszer Es Vegyeszet N-(Lower alkyl)-phenylisopropylamines
US3485874A (en) * 1966-05-04 1969-12-23 Chinoin Gyogyszer Es Vegyeszet Ortho and para bromophenyl isopropyl methylamines

Also Published As

Publication number Publication date
MD87B1 (en) 1994-11-30

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20050530