ES8105967A1 - A procedure for the preparation of cyclhexadene derivatives. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the preparation of cyclhexadene derivatives. (Machine-translation by Google Translate, not legally binding)
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication date
Application filed by F Hoffmann La Roche AGfiledCriticalF Hoffmann La Roche AG
Priority to ES493541ApriorityCriticalpatent/ES493541A0/en
Publication of ES8105967A1publicationCriticalpatent/ES8105967A1/en
Publication of ES493541A0publicationCriticalpatent/ES493541A0/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PROCEDURE FOR THE OBTAINING OF CYCLOHEXADIENE DERIVATIVES FROM FORMULA (I), OF ITS ADDITIONAL SALTS OF ACID AND, EVENTUALLY, OF THE OPTIMALLY ACTIVE ENANTIOMERS, FORMULA IN WHICH ONE OF THE RADICALS R1 AND R4 ARE HYDROGEN HYDROGEN OR METHYL, R2 IS HYDROGEN, METHYL OR ETHYL, AND R3 IS METHYL OR ETHYL. IT IS BASED ON THE REACTION OF A COMPOUND OF FORMULA (II) WITH AN AMINE OF FORMULA R2NHR3, IN WHICH R1, R2, R3 AND R4 ARE THE SAME AS IN FORMULA (I), IN THE PRESENCE OF BOROHIDRIDE, REDUCING AGENT, IN A ORGANIC SOLVENT CONSTITUTED BY A LOWER ALCANOL AND AT A TEMPERATURE BETWEEN -10ºC AND 50 GC. THE RACEMATE OBTAINED CAN BE SOLVED BY KNOWN METHODS AND TRANSFORMED IN THE ACID ADDITION SALT. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THEIR ANALGESIC ACTIVITY. *FORMULA* (Machine-translation by Google Translate, not legally binding)
ES493541A1980-07-211980-07-21
A PROCEDURE FOR THE PREPARATION OF CYCLE-HEXADIENE DERIVATIVES
GrantedES493541A0
(en)
Improvements in the construction of appliances for the application of electroacupuncture (Machine-translation by Google Translate, not legally binding)