MD4851B1 - Utilizarea derivatului de glutarimidă pentru depăşirea rezistenţei la steroizi - Google Patents
Utilizarea derivatului de glutarimidă pentru depăşirea rezistenţei la steroiziInfo
- Publication number
- MD4851B1 MD4851B1 MDA20210032A MD20210032A MD4851B1 MD 4851 B1 MD4851 B1 MD 4851B1 MD A20210032 A MDA20210032 A MD A20210032A MD 20210032 A MD20210032 A MD 20210032A MD 4851 B1 MD4851 B1 MD 4851B1
- Authority
- MD
- Moldova
- Prior art keywords
- steroids
- overcoming resistance
- glutarimide derivative
- patients
- treating
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title abstract 2
- KNCYXPMJDCCGSJ-UHFFFAOYSA-N piperidine-2,6-dione Chemical class O=C1CCCC(=O)N1 KNCYXPMJDCCGSJ-UHFFFAOYSA-N 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- -1 1-(2-(1H-imidazol-4-yl)ethyl)piperidine-2,6-dione compound Chemical class 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 abstract 1
- 102000008070 Interferon-gamma Human genes 0.000 abstract 1
- 108010074328 Interferon-gamma Proteins 0.000 abstract 1
- 208000021386 Sjogren Syndrome Diseases 0.000 abstract 1
- 201000009594 Systemic Scleroderma Diseases 0.000 abstract 1
- 206010042953 Systemic sclerosis Diseases 0.000 abstract 1
- 230000001594 aberrant effect Effects 0.000 abstract 1
- 201000001981 dermatomyositis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 229960003130 interferon gamma Drugs 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Invenţia se referă la medicină, în particular, la un medicament nou, eficient pentru tratamentul bolilor, asociate cu semnalizarea aberantă a interferonului gamma, cum ar fi sindromul Sjogren, dermatomiozita, lupusul eritematos sistemic sau scleroza sistemică, precum şi în tratamentul pacienţilor, care suferă de tuse, şi tratamentul tulburărilor la pacienţii cu rezistenţă la steroizi, cum ar fi bolile tractului gastro-intestinal, prin utilizarea compusului 1-(2-(1H-imidazol-4-il)etil)piperidin-2,6-dionă:.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2018141291A RU2712281C1 (ru) | 2018-11-23 | 2018-11-23 | Применение производного глутаримида для преодоления резистентности к стероидам и терапии заболеваний, ассоциированных с аберрантным сигналингом интерферона гамма |
PCT/RU2019/050225 WO2020106191A1 (ru) | 2018-11-23 | 2019-11-22 | Производное глутаримида для преодоления резистентности к стероидам |
Publications (3)
Publication Number | Publication Date |
---|---|
MD20210032A2 MD20210032A2 (ro) | 2021-09-30 |
MD4851B1 true MD4851B1 (ro) | 2023-04-30 |
MD4851C1 MD4851C1 (ro) | 2023-11-30 |
Family
ID=69624712
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20210050A MD4844C1 (ro) | 2018-11-23 | 2019-11-22 | Utilizare a derivatului de glutarimidă pentru depăşirea rezistenţei la steroizi |
MDA20210032A MD4851C1 (ro) | 2018-11-23 | 2019-11-22 | Utilizarea derivatului de glutarimidă pentru depăşirea rezistenţei la steroizi |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20210050A MD4844C1 (ro) | 2018-11-23 | 2019-11-22 | Utilizare a derivatului de glutarimidă pentru depăşirea rezistenţei la steroizi |
Country Status (18)
Country | Link |
---|---|
US (1) | US20220362230A1 (ro) |
EP (2) | EP3884945A4 (ro) |
JP (2) | JP2022508167A (ro) |
KR (2) | KR20210095652A (ro) |
CN (2) | CN113164464A (ro) |
AU (2) | AU2019384626A1 (ro) |
BR (1) | BR112021009801A2 (ro) |
CA (1) | CA3120882A1 (ro) |
CL (2) | CL2021001316A1 (ro) |
EA (1) | EA201992646A1 (ro) |
GE (1) | GEP20237467B (ro) |
IL (2) | IL297533A (ro) |
MD (2) | MD4844C1 (ro) |
MX (2) | MX2021006032A (ro) |
PH (1) | PH12021551152A1 (ro) |
RU (1) | RU2712281C1 (ro) |
WO (1) | WO2020106191A1 (ro) |
ZA (2) | ZA202104247B (ro) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023177329A1 (ru) * | 2022-03-18 | 2023-09-21 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Применение 1-(2-(1н-имидазол-4-ил)этил)пиперидин-2,6-диона для лечения кашля, вызванного вирусными инфекциями |
WO2023191666A1 (ru) * | 2022-03-29 | 2023-10-05 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Кристаллическая форма 1-(2-(1н-имидазол-4-ил)этил)пиперидин-2,6-диона и ее применение |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE9111874U1 (ro) * | 1991-09-23 | 1991-11-21 | Haag, Richard, 7181 Satteldorf, De | |
CA2129114A1 (en) * | 1992-02-07 | 1993-08-19 | Albert M. Kligman | Methods of treating inflammatory dermatoses |
US7544772B2 (en) * | 2001-06-26 | 2009-06-09 | Biomarck Pharmaceuticals, Ltd. | Methods for regulating inflammatory mediators and peptides useful therein |
US20040220155A1 (en) * | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
RU2404792C1 (ru) * | 2009-05-20 | 2010-11-27 | Общество с ограниченной ответственностью Научно-производственное предприятие "БИОНОКС" | Средство для преодоления стероидной резистентности |
BR112013020498A2 (pt) * | 2011-02-10 | 2016-08-09 | Genqual Corp | método para determinar a capacidade de resposta a inibidores e para tratamento de um sujeito |
CN110229140B (zh) * | 2013-04-12 | 2022-06-10 | 制药有限责任公司 | 戊二酰亚胺衍生物、其用途、基于所述衍生物的药物组合物及戊二酰亚胺衍生物的制备方法 |
RU2552929C1 (ru) * | 2013-11-14 | 2015-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний |
-
2018
- 2018-11-23 RU RU2018141291A patent/RU2712281C1/ru active
-
2019
- 2019-11-22 JP JP2021528866A patent/JP2022508167A/ja active Pending
- 2019-11-22 EP EP19886166.8A patent/EP3884945A4/en active Pending
- 2019-11-22 BR BR112021009801A patent/BR112021009801A2/pt unknown
- 2019-11-22 US US17/296,539 patent/US20220362230A1/en active Pending
- 2019-11-22 AU AU2019384626A patent/AU2019384626A1/en active Pending
- 2019-11-22 CN CN201980076564.4A patent/CN113164464A/zh active Pending
- 2019-11-22 CN CN202210260820.9A patent/CN114652721A/zh active Pending
- 2019-11-22 EP EP22210617.1A patent/EP4218758A3/en active Pending
- 2019-11-22 CA CA3120882A patent/CA3120882A1/en active Pending
- 2019-11-22 WO PCT/RU2019/050225 patent/WO2020106191A1/ru active Application Filing
- 2019-11-22 MX MX2021006032A patent/MX2021006032A/es unknown
- 2019-11-22 IL IL297533A patent/IL297533A/en unknown
- 2019-11-22 KR KR1020217019084A patent/KR20210095652A/ko unknown
- 2019-11-22 KR KR1020227040632A patent/KR20220162821A/ko active Application Filing
- 2019-11-22 MD MDA20210050A patent/MD4844C1/ro active IP Right Grant
- 2019-11-22 GE GEAP201915712A patent/GEP20237467B/en unknown
- 2019-11-22 MD MDA20210032A patent/MD4851C1/ro active IP Right Grant
- 2019-11-22 EA EA201992646A patent/EA201992646A1/ru unknown
-
2021
- 2021-05-19 CL CL2021001316A patent/CL2021001316A1/es unknown
- 2021-05-20 IL IL283317A patent/IL283317A/en unknown
- 2021-05-20 PH PH12021551152A patent/PH12021551152A1/en unknown
- 2021-05-21 MX MX2022013503A patent/MX2022013503A/es unknown
- 2021-06-21 ZA ZA2021/04247A patent/ZA202104247B/en unknown
-
2022
- 2022-03-21 CL CL2022000683A patent/CL2022000683A1/es unknown
- 2022-09-21 ZA ZA2022/10444A patent/ZA202210444B/en unknown
- 2022-10-21 AU AU2022256212A patent/AU2022256212A1/en active Pending
- 2022-11-17 JP JP2022184210A patent/JP2023015333A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MD20210032A2 (ro) | 2021-09-30 |
ZA202104247B (en) | 2023-03-29 |
MD4844C1 (ro) | 2023-09-30 |
AU2019384626A1 (en) | 2021-07-15 |
RU2712281C1 (ru) | 2020-01-28 |
JP2022508167A (ja) | 2022-01-19 |
CN114652721A (zh) | 2022-06-24 |
ZA202210444B (en) | 2023-01-25 |
GEP20237467B (en) | 2023-02-10 |
BR112021009801A2 (pt) | 2022-03-03 |
AU2022256212A1 (en) | 2022-12-08 |
EP4218758A3 (en) | 2023-08-23 |
CA3120882A1 (en) | 2020-05-28 |
MD20210050A2 (ro) | 2021-12-31 |
JP2023015333A (ja) | 2023-01-31 |
EP4218758A2 (en) | 2023-08-02 |
WO2020106191A1 (ru) | 2020-05-28 |
KR20210095652A (ko) | 2021-08-02 |
IL297533A (en) | 2022-12-01 |
CN113164464A (zh) | 2021-07-23 |
MX2021006032A (es) | 2021-07-06 |
MD4851C1 (ro) | 2023-11-30 |
US20220362230A1 (en) | 2022-11-17 |
MX2022013503A (es) | 2022-11-16 |
PH12021551152A1 (en) | 2021-10-25 |
EA201992646A1 (ru) | 2020-05-31 |
CL2021001316A1 (es) | 2021-10-29 |
MD4844B1 (ro) | 2023-02-28 |
IL283317A (en) | 2021-07-29 |
EP3884945A4 (en) | 2022-11-23 |
KR20220162821A (ko) | 2022-12-08 |
EP3884945A1 (en) | 2021-09-29 |
CL2022000683A1 (es) | 2022-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB9A | Change of applicant (patent for invention) |
Owner name: LTD VALENTA-INTELLEKT, RU UL. RYABINOVAYA, D. 26 BUILDING 10, CAB. 6-26, MOSCOW, 121471, FEDERATIA RUSA;IP NEBOLSIN VLADIMIR EVGHENIEVICH, RU STR. GOLITSYNSKAYA, 457, ISTRINSKIY R-N, D. BORZYE, MOSKOVSKAYA OBL., 143581, FEDERATIA RUSA Free format text: PREVIOUS APPLICANT: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU "PHARMENTERPRISES",RU 121205, MOSCOW, MOZHAISKY MUNICIPAL DISTRICT, TERRITORY OF THE SKOLKOVO INNOVATION CENTER, BOLSHOY BOULEVARD, HOUSE 42, BUILDING 1, FLOOR 3, ROOM 1280, FEDERATIA RUSA |
|
FG4A | Patent for invention issued |