MD4546B1 - Produs de comicronizare cu conţinut de un modulator selectiv al receptorului de progesteron - Google Patents
Produs de comicronizare cu conţinut de un modulator selectiv al receptorului de progesteronInfo
- Publication number
- MD4546B1 MD4546B1 MDA20150054A MD20150054A MD4546B1 MD 4546 B1 MD4546 B1 MD 4546B1 MD A20150054 A MDA20150054 A MD A20150054A MD 20150054 A MD20150054 A MD 20150054A MD 4546 B1 MD4546 B1 MD 4546B1
- Authority
- MD
- Moldova
- Prior art keywords
- micronisation
- product
- receptor modulator
- selective progesterone
- micronisation product
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Invenţia se referă la un produs de comicronizare ce cuprinde un ingredient activ selectat din grupul format din modulatori selectivi ai receptorului de progesteron, metaboliţi ai acestora şi amestecuri de metaboliţi, şi un excipient polimeric în bază de N-vinil-2-pirolidonă.Invenţia de asemenea se referă la un procedeu de obţinere a produsului de comicronizare şi la o compoziţie farmaceutică ce conţine produsul de comicronizare menţionat.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1260605A FR2997628B1 (fr) | 2012-11-08 | 2012-11-08 | Produit de co-micronisation comprenant un modulateur selectif des recepteurs a la progesterone |
PCT/FR2013/052671 WO2014072647A1 (fr) | 2012-11-08 | 2013-11-07 | Produit de co-micronisation comprenant un modulateur selectif du recepteur a la progesterone |
Publications (4)
Publication Number | Publication Date |
---|---|
MD20150054A2 MD20150054A2 (ro) | 2015-10-31 |
MD4546B1 true MD4546B1 (ro) | 2018-01-31 |
MD4546B9 MD4546B9 (ro) | 2018-08-31 |
MD4546C1 MD4546C1 (ro) | 2019-03-31 |
Family
ID=47714259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20150054A MD4546C1 (ro) | 2012-11-08 | 2013-11-07 | Produs de comicronizare cu conţinut de un modulator selectiv al receptorului de progesteron |
Country Status (21)
Country | Link |
---|---|
US (1) | US20150258118A1 (ro) |
EP (1) | EP2916823B1 (ro) |
JP (1) | JP2015536969A (ro) |
CN (1) | CN105073098B (ro) |
CR (1) | CR20150298A (ro) |
CY (1) | CY1118884T1 (ro) |
DK (1) | DK2916823T3 (ro) |
EA (1) | EA029643B1 (ro) |
EC (1) | ECSP15022505A (ro) |
ES (1) | ES2625012T3 (ro) |
FR (1) | FR2997628B1 (ro) |
GE (1) | GEP201706648B (ro) |
HR (1) | HRP20170686T1 (ro) |
LT (1) | LT2916823T (ro) |
MD (1) | MD4546C1 (ro) |
PL (1) | PL2916823T3 (ro) |
PT (1) | PT2916823T (ro) |
RS (1) | RS55956B1 (ro) |
SI (1) | SI2916823T1 (ro) |
UA (1) | UA115573C2 (ro) |
WO (1) | WO2014072647A1 (ro) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106265533A (zh) * | 2016-10-10 | 2017-01-04 | 朱隆娅 | 一种阿德呋啉颗粒剂及其制备方法 |
FR3060389B1 (fr) * | 2016-12-20 | 2019-05-31 | Laboratoire Hra-Pharma | Comprime enrobe comprenant de l'ulipristal acetate ou un de ses metabolites |
EP3895691A1 (en) | 2020-04-15 | 2021-10-20 | LTS Lohmann Therapie-Systeme AG | Ulipristal acetate otf |
US11878025B2 (en) | 2021-09-06 | 2024-01-23 | Slayback Pharma Llc | Pharmaceutical compositions of mifepristone |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0422100A1 (en) * | 1988-06-23 | 1991-04-17 | Res Triangle Inst | 11-BETA SUBSTITUTED PROGESTERONE ANALOGS. |
EP0803250A1 (en) * | 1996-04-24 | 1997-10-29 | American Home Food Products, Inc. | Controlled release of steroids from sugar coatings |
EP1602662A1 (en) * | 2003-01-22 | 2005-12-07 | Crystal Pharma, S.A. | Method of obtaining 17alpha-acetoxy-11beta-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione |
WO2008067086A2 (en) * | 2006-10-24 | 2008-06-05 | Repros Therapeutics Inc. | Compositions and methods for suppressing endometrial proliferation |
WO2009134723A1 (en) * | 2008-04-28 | 2009-11-05 | Repros Therapeutics Inc. | Pregesteron antagonists such as cdb-4124 in the treatment of breast cancer |
US20100144692A1 (en) * | 2008-12-08 | 2010-06-10 | Laboratoire Hra Pharma | Ulipristal Acetate Tablets |
CN102871977A (zh) * | 2012-10-19 | 2013-01-16 | 北京紫竹药业有限公司 | 醋酸优力司特分散片及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004099442A (ja) * | 2002-09-04 | 2004-04-02 | Nisshin Pharma Inc | 難溶性薬物含有製剤およびその製造方法 |
JP5017109B2 (ja) | 2004-07-09 | 2012-09-05 | ザ・ポピュレイション・カウンシル,インコーポレイテッド | プロゲステロン受容体モジュレーターを含有する徐放性組成物 |
WO2008083192A2 (en) * | 2006-12-28 | 2008-07-10 | Repros Therapeutics Inc. | Methods and formulations for improved bioavailability of antiprogestins |
JP2008169135A (ja) * | 2007-01-11 | 2008-07-24 | Takada Seiyaku Kk | グリメピリド組成物の製造方法 |
US8299050B2 (en) * | 2008-01-29 | 2012-10-30 | Laboratoire Hra-Pharma | Method for treating uterine fibroids |
BRPI1014035A2 (pt) | 2009-04-14 | 2016-04-12 | Hra Pharma Lab | método para contracepção. |
EP2535114A4 (en) * | 2009-11-13 | 2015-11-18 | Moriroku Chemicals Company Ltd | PROCESS FOR PRODUCING FINE POWDER AND FINE POWDER PRODUCED ACCORDING TO THIS METHOD |
FR2988610B1 (fr) * | 2012-03-30 | 2014-10-31 | Effik | Progestatif co-micronise avec un polymere portant le groupe pyrrolidone, composition et utilisations |
-
2012
- 2012-11-08 FR FR1260605A patent/FR2997628B1/fr not_active Expired - Fee Related
-
2013
- 2013-07-11 UA UAA201505667A patent/UA115573C2/uk unknown
- 2013-11-07 CN CN201380069081.4A patent/CN105073098B/zh not_active Expired - Fee Related
- 2013-11-07 PT PT138016407T patent/PT2916823T/pt unknown
- 2013-11-07 ES ES13801640.7T patent/ES2625012T3/es active Active
- 2013-11-07 SI SI201330642T patent/SI2916823T1/sl unknown
- 2013-11-07 PL PL13801640T patent/PL2916823T3/pl unknown
- 2013-11-07 JP JP2015541215A patent/JP2015536969A/ja active Pending
- 2013-11-07 EP EP13801640.7A patent/EP2916823B1/fr active Active
- 2013-11-07 MD MDA20150054A patent/MD4546C1/ro not_active IP Right Cessation
- 2013-11-07 GE GEAP201313848A patent/GEP201706648B/en unknown
- 2013-11-07 LT LTEP13801640.7T patent/LT2916823T/lt unknown
- 2013-11-07 DK DK13801640.7T patent/DK2916823T3/en active
- 2013-11-07 WO PCT/FR2013/052671 patent/WO2014072647A1/fr active Application Filing
- 2013-11-07 EA EA201500514A patent/EA029643B1/ru not_active IP Right Cessation
- 2013-11-07 RS RS20170457A patent/RS55956B1/sr unknown
- 2013-11-07 US US14/441,054 patent/US20150258118A1/en not_active Abandoned
-
2015
- 2015-06-05 EC ECIEPI201522505A patent/ECSP15022505A/es unknown
- 2015-06-05 CR CR20150298A patent/CR20150298A/es unknown
-
2017
- 2017-05-08 HR HRP20170686TT patent/HRP20170686T1/hr unknown
- 2017-05-10 CY CY20171100500T patent/CY1118884T1/el unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0422100A1 (en) * | 1988-06-23 | 1991-04-17 | Res Triangle Inst | 11-BETA SUBSTITUTED PROGESTERONE ANALOGS. |
EP0803250A1 (en) * | 1996-04-24 | 1997-10-29 | American Home Food Products, Inc. | Controlled release of steroids from sugar coatings |
EP1602662A1 (en) * | 2003-01-22 | 2005-12-07 | Crystal Pharma, S.A. | Method of obtaining 17alpha-acetoxy-11beta-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione |
WO2008067086A2 (en) * | 2006-10-24 | 2008-06-05 | Repros Therapeutics Inc. | Compositions and methods for suppressing endometrial proliferation |
WO2009134723A1 (en) * | 2008-04-28 | 2009-11-05 | Repros Therapeutics Inc. | Pregesteron antagonists such as cdb-4124 in the treatment of breast cancer |
US20100144692A1 (en) * | 2008-12-08 | 2010-06-10 | Laboratoire Hra Pharma | Ulipristal Acetate Tablets |
WO2010066749A2 (en) * | 2008-12-08 | 2010-06-17 | Laboratoire Hra Pharma | Ulipristal acetate tablets |
CN102871977A (zh) * | 2012-10-19 | 2013-01-16 | 北京紫竹药业有限公司 | 醋酸优力司特分散片及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN105073098B (zh) | 2019-02-19 |
RS55956B1 (sr) | 2017-09-29 |
EP2916823A1 (fr) | 2015-09-16 |
HRP20170686T1 (hr) | 2017-09-08 |
CN105073098A (zh) | 2015-11-18 |
EA029643B1 (ru) | 2018-04-30 |
EP2916823B1 (fr) | 2017-02-15 |
PT2916823T (pt) | 2017-05-22 |
FR2997628A1 (fr) | 2014-05-09 |
MD4546B9 (ro) | 2018-08-31 |
CY1118884T1 (el) | 2018-01-10 |
PL2916823T3 (pl) | 2017-08-31 |
UA115573C2 (uk) | 2017-11-27 |
LT2916823T (lt) | 2017-07-25 |
US20150258118A1 (en) | 2015-09-17 |
MD4546C1 (ro) | 2019-03-31 |
EA201500514A1 (ru) | 2015-09-30 |
ES2625012T3 (es) | 2017-07-18 |
JP2015536969A (ja) | 2015-12-24 |
FR2997628B1 (fr) | 2015-01-16 |
MD20150054A2 (ro) | 2015-10-31 |
CR20150298A (es) | 2015-08-14 |
DK2916823T3 (en) | 2017-05-15 |
SI2916823T1 (sl) | 2017-08-31 |
ECSP15022505A (es) | 2016-01-29 |
WO2014072647A1 (fr) | 2014-05-15 |
GEP201706648B (en) | 2017-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |