MD430C2 - Procedeu de obţinere a interferonelor leucocitare umane - Google Patents
Procedeu de obţinere a interferonelor leucocitare umaneInfo
- Publication number
- MD430C2 MD430C2 MD95-0076A MD950076A MD430C2 MD 430 C2 MD430 C2 MD 430C2 MD 950076 A MD950076 A MD 950076A MD 430 C2 MD430 C2 MD 430C2
- Authority
- MD
- Moldova
- Prior art keywords
- pst
- pbr
- leucocytar
- interferone
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16498680A | 1980-07-01 | 1980-07-01 | |
US18490980A | 1980-09-08 | 1980-09-08 | |
US20557880A | 1980-11-10 | 1980-11-10 | |
US06/256,204 US6610830B1 (en) | 1980-07-01 | 1981-04-21 | Microbial production of mature human leukocyte interferons |
Publications (1)
Publication Number | Publication Date |
---|---|
MD430C2 true MD430C2 (ro) | 1996-06-30 |
Family
ID=27389083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD95-0076A MD430C2 (ro) | 1980-07-01 | 1994-12-30 | Procedeu de obţinere a interferonelor leucocitare umane |
Country Status (6)
Country | Link |
---|---|
US (2) | US6610830B1 (ko) |
KR (1) | KR860001558B1 (ko) |
CA (1) | CA1341583C (ko) |
GE (1) | GEP20074163B (ko) |
MD (1) | MD430C2 (ko) |
ZW (1) | ZW14781A1 (ko) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6835557B1 (en) * | 1980-01-08 | 2004-12-28 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides |
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
EP2213743A1 (en) | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7959910B2 (en) * | 2000-07-31 | 2011-06-14 | Biolex Therapeutics, Inc. | C-terminally truncated interferon alpha variants |
US7666995B2 (en) * | 2000-11-03 | 2010-02-23 | Pestka Biomedical Laboratories | Interferons, uses and compositions related thereto |
FR2822845B1 (fr) * | 2001-03-30 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques |
JP2005517648A (ja) * | 2001-12-07 | 2005-06-16 | インターミューン インコーポレイテッド | 肝炎ウイルス感染症を治療するための組成物および方法 |
EP2261250B1 (en) | 2001-12-21 | 2015-07-01 | Human Genome Sciences, Inc. | GCSF-Albumin fusion proteins |
KR101271635B1 (ko) * | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 알부민 융합 단백질 |
ATE386054T1 (de) * | 2002-08-31 | 2008-03-15 | Cj Corp | Glycosylierte humane interferon alpha isoform |
ES2343518T3 (es) * | 2002-09-09 | 2010-08-03 | Hanall Biopharma Co., Ltd. | Polipeptidos interferon alfa modificados resistentes a proteasas. |
US7314613B2 (en) * | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
WO2004046365A2 (en) * | 2002-11-18 | 2004-06-03 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
US20040136952A1 (en) * | 2002-12-26 | 2004-07-15 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
EA008866B1 (ru) | 2002-12-26 | 2007-08-31 | Маунтин Вью Фамэсьютикэлс, Инк. | ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
BRPI0507159A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos em feixe de quatro hélices humanos modificados e seus usos |
AU2005245918A1 (en) * | 2004-05-19 | 2005-12-01 | F. Hoffmann-La Roche Ag | Interferon-alpha polypeptides and conjugates |
US20060024272A1 (en) * | 2004-07-29 | 2006-02-02 | Large Scale Biology Corporation | C-terminally truncated interferon |
WO2006111745A2 (en) * | 2005-04-20 | 2006-10-26 | Viragen Incorporated | Composition and method for treating viral infection |
CN101501068A (zh) * | 2005-05-18 | 2009-08-05 | 马克西根公司 | 改进的α-干扰素多肽 |
KR20080021614A (ko) * | 2005-05-26 | 2008-03-07 | 쉐링 코포레이션 | 인터페론-IgG 융합체 |
SG165353A1 (en) * | 2005-06-03 | 2010-10-28 | Ambrx Inc | Improved human interferon molecules and their uses |
US7770595B2 (en) * | 2006-04-27 | 2010-08-10 | Sko Flo Industries, Inc. | Flow control valve |
US8679472B1 (en) | 2006-10-05 | 2014-03-25 | Merck, Sharp & Dohme Corp. | Crystal of human interferon alpha 2B in complex with zinc |
WO2008127711A2 (en) * | 2007-04-11 | 2008-10-23 | Pestka Biomedical Laboratories, Inc. | Interferons of rhesus and cynomolgus origin and uses thereof |
CN101675071B (zh) | 2007-05-02 | 2014-06-18 | Ambrx公司 | 经修饰干扰素β多肽和其用途 |
CA2694440A1 (en) * | 2007-07-25 | 2009-01-29 | Biolex Therapeutics, Inc. | Controlled release interferon drug products and treatment of hcv infection using same |
CN101636411B (zh) * | 2007-09-04 | 2013-01-09 | 厦门伯赛基因转录技术有限公司 | 聚乙二醇修饰的干扰素α2a及其制备方法和应用 |
NZ602170A (en) | 2008-02-08 | 2014-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
UA103492C2 (ru) | 2008-07-08 | 2013-10-25 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Ингибиторы пролиферации и активации переносчика сигнала и активатора транскрипции (stats) |
CN103732242A (zh) | 2011-06-23 | 2014-04-16 | 迪格纳生物技术公司 | 用与IFN-α2b组合的IFN-α5在患者群体中治疗慢性丙型肝炎 |
WO2013134138A1 (en) | 2012-03-03 | 2013-09-12 | Immungene, Inc. | Engineered antibody-interferon mutant fusion molecules |
EP2841574A2 (en) * | 2012-03-30 | 2015-03-04 | Krishnan, Archana Rajesh | Codon optimized sequence for an antiviral protein |
CU24554B1 (es) * | 2018-05-07 | 2021-11-04 | Ct Inmunologia Molecular | Proteínas de fusión compuestas por una muteína de interleucina 2 e interferón tipo 1 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT373279B (de) | 1977-11-08 | 1984-01-10 | Genentech Inc | Verfahren zur herstellung eines rekombinationsclonbildungstraegers |
US4411994A (en) | 1978-06-08 | 1983-10-25 | The President And Fellows Of Harvard College | Protein synthesis |
IN150740B (ko) * | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
US4503035B1 (en) | 1978-11-24 | 1996-03-19 | Hoffmann La Roche | Protein purification process and product |
US4332892A (en) | 1979-01-15 | 1982-06-01 | President And Fellows Of Harvard College | Protein synthesis |
ES479300A1 (es) | 1979-04-04 | 1979-07-01 | Cusi Lab | Procedimiento de obtencio de &-metil, 4(2'tienil carbonilz) fenil acetato de p-acetamido fenol. |
US4342832A (en) | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
US4418149A (en) | 1980-01-10 | 1983-11-29 | President And Fellows Of Harvard College | Fused hybrid gene |
US4810645A (en) | 1981-08-14 | 1989-03-07 | Hoffmann-La Roche Inc. | Microbial production of mature human leukocyte interferon K and L |
US4801685A (en) | 1981-08-14 | 1989-01-31 | Hoffmann-La Roche Inc. | Microbial production of mature human leukocyte interferon K and L |
-
1981
- 1981-04-21 US US06/256,204 patent/US6610830B1/en not_active Expired - Lifetime
- 1981-06-26 ZW ZW147/81A patent/ZW14781A1/xx unknown
- 1981-06-30 CA CA000380922A patent/CA1341583C/en not_active Expired - Fee Related
- 1981-07-01 KR KR1019810002386A patent/KR860001558B1/ko active
-
1988
- 1988-01-19 US US07/145,002 patent/US6482613B1/en not_active Expired - Lifetime
-
1994
- 1994-12-30 MD MD95-0076A patent/MD430C2/ro unknown
-
2006
- 2006-07-28 GE GEAP20069547A patent/GEP20074163B/en unknown
Non-Patent Citations (1)
Title |
---|
Shigekazu N. et al. Synthensin E. coli of a polypeptide with human leukocyte interferon activity. Nature, v. 284, March, 1980, p. 316-320. * |
Also Published As
Publication number | Publication date |
---|---|
CA1341583C (en) | 2008-11-18 |
US6610830B1 (en) | 2003-08-26 |
ZW14781A1 (en) | 1982-04-21 |
GEP20074163B (en) | 2007-07-10 |
KR830006422A (ko) | 1983-09-24 |
US6482613B1 (en) | 2002-11-19 |
KR860001558B1 (ko) | 1986-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MD430C2 (ro) | Procedeu de obţinere a interferonelor leucocitare umane | |
EP0653940A4 (en) | GLIALMITOGENIC FACTORS, THEIR PRODUCTION AND USE. | |
MD431C2 (ro) | Procedeu de obţinere a interferonului leucocitar | |
DK288183D0 (da) | Fremgangsmade til fremstilling af et oligonucleotidt terapeutisk middel | |
KR970000808B1 (en) | Human proapolipoprotein a-1 expression | |
MY101972A (en) | Primate interleukin - 4 | |
AU1348083A (en) | Dna sequences, recombinant dna molecules and preparations of cholera toxin | |
ZA859437B (en) | Dna sequence encoding a hirudin-like protein and process for preparing such protein | |
ES8602119A1 (es) | Metodo para preparar inmunoglobulinas en celulas hospedantes recombinantes | |
DK188582A (da) | Bacillus-kloningsvektorer rekombinations-dna-molekyler bacillus-vaerter transformeret dermed samt fremgangsmaader til ekspressionaf fremmede dna-sekvenser og fremstilling af polypeptideer som er kodede dermed | |
DE3586697D1 (en) | Aktive thymopentin-analoga. | |
LTIP1753A (en) | Dna sequences coding for proteins, biotechnological methods for the preparation of said proteins and pharmaceutical compositions containing said proteins | |
ES8706827A1 (es) | Procedimiento para preparar polipeptidos. | |
JPS615392B2 (ko) | ||
IL110942A0 (en) | Grb3-3 gene, its variants and their uses | |
GB9215232D0 (en) | Vaccines | |
GB2171703B (en) | Expression-secretion vector for gene expression and protein secretion, recombinant dna including the vector, and method of producing proteins by use of the re | |
DK0643719T3 (da) | Nukleinsyresekvenser, som koder for eller er komplementære til nukleinsyresekvenser, som koder for interleukin 9-receptor | |
ATE215123T1 (de) | Or-1, ein wais-rezeptor der nuklearen rezeptoren familie | |
WO1990003394A3 (fr) | Nouvelles lymphokines, sequences d'adn codant pour ces lymphokines et compositions pharmaceutiques contenant ces lymphokines | |
IT8521507A0 (it) | Vettore di clonaggio, molecole di dna ricombinante, ceppi di bacillus subtilis trasformati con dette molecole e metodi per l'espressione di geni eterologhi e produzione e secrezione di proteine codificate da detti geni. |