MD4275C1 - Procedeu de sinteză a ivabradinei şi a sărurilor sale de adiţie cu un acid farmaceutic acceptabil - Google Patents

Procedeu de sinteză a ivabradinei şi a sărurilor sale de adiţie cu un acid farmaceutic acceptabil

Info

Publication number
MD4275C1
MD4275C1 MDA20120123A MD20120123A MD4275C1 MD 4275 C1 MD4275 C1 MD 4275C1 MD A20120123 A MDA20120123 A MD A20120123A MD 20120123 A MD20120123 A MD 20120123A MD 4275 C1 MD4275 C1 MD 4275C1
Authority
MD
Moldova
Prior art keywords
ivabradine
synthesis
pharmaceutically acceptable
addition salts
acceptable acid
Prior art date
Application number
MDA20120123A
Other languages
English (en)
Russian (ru)
Other versions
MD4275B1 (ro
Inventor
Жан-Люк Рено
Николас ПАННЕТЬЕ
Сильвен ГАЙЯР
Жан-Пьер Лекув
Люсиль Весс-Людо
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47355960&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD4275(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of MD4275B1 publication Critical patent/MD4275B1/ro
Publication of MD4275C1 publication Critical patent/MD4275C1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Invenţia se referă la un procedeu de sinteză a ivabradinei cu formula (I), a sărurilor sale de adiţie cu un acid farmaceutic acceptabil şi a hidraţilor acestora:.Procedeul, conform invenţiei, constă în aceea că compusul cu formula (V):se supune unei reacţii de aminare reductivă cu amina cu formula (VI):,în prezenţa acidului formic şi a trietilaminei, în absenţa solventului sau într-un solvent alcoolic.
MDA20120123A 2011-12-20 2012-12-14 Procedeu de sinteză a ivabradinei şi a sărurilor sale de adiţie cu un acid farmaceutic acceptabil MD4275C1 (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1103934A FR2984320B1 (fr) 2011-12-20 2011-12-20 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number Publication Date
MD4275B1 MD4275B1 (ro) 2014-02-28
MD4275C1 true MD4275C1 (ro) 2014-09-30

Family

ID=47355960

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20120123A MD4275C1 (ro) 2011-12-20 2012-12-14 Procedeu de sinteză a ivabradinei şi a sărurilor sale de adiţie cu un acid farmaceutic acceptabil

Country Status (35)

Country Link
US (1) US8507668B2 (ro)
EP (1) EP2607354B1 (ro)
JP (1) JP5531084B2 (ro)
KR (1) KR101479986B1 (ro)
CN (1) CN103172567B (ro)
AR (1) AR089325A1 (ro)
AU (1) AU2012261583B2 (ro)
BR (1) BR102012032562A2 (ro)
CA (1) CA2798633C (ro)
CL (1) CL2012003579A1 (ro)
CY (1) CY1115620T1 (ro)
DK (1) DK2607354T3 (ro)
EA (1) EA021713B1 (ro)
ES (1) ES2516290T3 (ro)
FR (1) FR2984320B1 (ro)
GE (1) GEP20156245B (ro)
HK (1) HK1186734A1 (ro)
HR (1) HRP20140839T1 (ro)
JO (1) JO3083B1 (ro)
MA (1) MA34868B1 (ro)
MD (1) MD4275C1 (ro)
MX (1) MX2012014321A (ro)
MY (1) MY160928A (ro)
PE (1) PE20131325A1 (ro)
PL (1) PL2607354T3 (ro)
PT (1) PT2607354E (ro)
RS (1) RS53470B (ro)
SA (1) SA112340106B1 (ro)
SG (1) SG191498A1 (ro)
SI (1) SI2607354T1 (ro)
TW (1) TWI440628B (ro)
UA (1) UA111156C2 (ro)
UY (1) UY34508A (ro)
WO (1) WO2013093333A1 (ro)
ZA (1) ZA201209369B (ro)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0534859A1 (fr) * 1991-09-27 1993-03-31 Adir Et Compagnie 3-Benzazépin-zones substituées par un groupe benzocyclobutyl- ou indanyl-alkyl-amino-alkyle, utiles dans le traitement des affections cardiovasculaires
EP1589005A1 (fr) * 2004-04-13 2005-10-26 Les Laboratoires Servier Procédé de synthèse de l'ivabradine et de ses sels d'addition à un acide pharmaceutiquement acceptable
EP2036892A1 (fr) * 2007-09-11 2009-03-18 Les Laboratoires Servier Dérivés de 1,2,4,5-tétrahydro-3H-benzazépines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP2202225A1 (fr) * 2008-12-24 2010-06-30 Les Laboratoires Servier Nouveau procédé de synthèse de l'ivabradine et de ses sels d'addition à un acide pharmaceutiquemenet acceptable
US20110294999A1 (en) * 2009-02-04 2011-12-01 Les Laboratoires Servier Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
JP5632279B2 (ja) * 2007-05-30 2014-11-26 アイエヌディー−スイフト ラボラトリーズ リミテッド 塩酸イバブラジンの調製方法及びポリモルフ
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
PL2398808T3 (pl) * 2009-02-17 2014-04-30 Mallinckrodt Llc Sposób redukcyjnego alkilowania normorfinanów
ME00986B (me) * 2009-03-31 2012-06-20 Servier Lab Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0534859A1 (fr) * 1991-09-27 1993-03-31 Adir Et Compagnie 3-Benzazépin-zones substituées par un groupe benzocyclobutyl- ou indanyl-alkyl-amino-alkyle, utiles dans le traitement des affections cardiovasculaires
EP1589005A1 (fr) * 2004-04-13 2005-10-26 Les Laboratoires Servier Procédé de synthèse de l'ivabradine et de ses sels d'addition à un acide pharmaceutiquement acceptable
EP2036892A1 (fr) * 2007-09-11 2009-03-18 Les Laboratoires Servier Dérivés de 1,2,4,5-tétrahydro-3H-benzazépines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP2202225A1 (fr) * 2008-12-24 2010-06-30 Les Laboratoires Servier Nouveau procédé de synthèse de l'ivabradine et de ses sels d'addition à un acide pharmaceutiquemenet acceptable
US20110294999A1 (en) * 2009-02-04 2011-12-01 Les Laboratoires Servier Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Also Published As

Publication number Publication date
NZ604890A (en) 2014-03-28
CA2798633C (fr) 2014-08-19
CN103172567B (zh) 2015-08-12
RS53470B (en) 2014-12-31
CL2012003579A1 (es) 2014-09-05
CA2798633A1 (fr) 2013-06-20
SA112340106B1 (ar) 2015-07-09
EP2607354A1 (fr) 2013-06-26
KR20130071389A (ko) 2013-06-28
AU2012261583A1 (en) 2013-07-04
ZA201209369B (en) 2013-08-28
EA201201571A1 (ru) 2013-07-30
US20130158257A1 (en) 2013-06-20
BR102012032562A2 (pt) 2013-11-12
HRP20140839T1 (hr) 2014-10-24
GEP20156245B (en) 2015-02-10
CN103172567A (zh) 2013-06-26
EP2607354B1 (fr) 2014-07-16
DK2607354T3 (da) 2014-10-13
SI2607354T1 (sl) 2014-10-30
FR2984320A1 (fr) 2013-06-21
FR2984320B1 (fr) 2013-11-29
TW201331183A (zh) 2013-08-01
PE20131325A1 (es) 2013-11-15
KR101479986B1 (ko) 2015-01-08
ES2516290T3 (es) 2014-10-30
MX2012014321A (es) 2013-06-19
MD4275B1 (ro) 2014-02-28
JP2013129656A (ja) 2013-07-04
EA021713B1 (ru) 2015-08-31
PL2607354T3 (pl) 2014-10-31
JP5531084B2 (ja) 2014-06-25
PT2607354E (pt) 2014-08-27
CY1115620T1 (el) 2017-01-04
WO2013093333A1 (fr) 2013-06-27
TWI440628B (zh) 2014-06-11
HK1186734A1 (en) 2014-03-21
MA34868B1 (fr) 2014-02-01
UY34508A (es) 2013-06-28
SG191498A1 (en) 2013-07-31
MY160928A (en) 2017-03-31
US8507668B2 (en) 2013-08-13
JO3083B1 (ar) 2017-03-15
UA111156C2 (uk) 2016-04-11
AR089325A1 (es) 2014-08-13
AU2012261583B2 (en) 2014-01-16

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees