MD4252C1 - Catena-(µ-nitrato)[µ-(2-hidroxibenziliden)-4-prop-2-en-1-iltiosemicarbazon-S]argint cu activitate antimicrobiană faţă de bacteriile Salmonella abony - Google Patents
Catena-(µ-nitrato)[µ-(2-hidroxibenziliden)-4-prop-2-en-1-iltiosemicarbazon-S]argint cu activitate antimicrobiană faţă de bacteriile Salmonella abony Download PDFInfo
- Publication number
- MD4252C1 MD4252C1 MDA20120044A MD20120044A MD4252C1 MD 4252 C1 MD4252 C1 MD 4252C1 MD A20120044 A MDA20120044 A MD A20120044A MD 20120044 A MD20120044 A MD 20120044A MD 4252 C1 MD4252 C1 MD 4252C1
- Authority
- MD
- Moldova
- Prior art keywords
- silver
- nitrato
- hydroxybenzylidene
- prop
- activity against
- Prior art date
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- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 12
- 241001148132 Salmonella enterica subsp. enterica serovar Abony Species 0.000 title claims abstract description 10
- 229910052709 silver Inorganic materials 0.000 title claims abstract description 9
- 239000004332 silver Substances 0.000 title claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 17
- 239000013081 microcrystal Substances 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 abstract description 7
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 abstract description 3
- 239000004599 antimicrobial Substances 0.000 abstract description 2
- 229910052723 transition metal Inorganic materials 0.000 abstract description 2
- 150000003624 transition metals Chemical class 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 10
- 244000005700 microbiome Species 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 125000004430 oxygen atom Chemical group O* 0.000 description 6
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical class OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 description 6
- 125000004429 atom Chemical group 0.000 description 5
- 150000003378 silver Chemical group 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 125000004434 sulfur atom Chemical group 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 229910002651 NO3 Inorganic materials 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical group [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- -1 monodeprotonated 2-formylpyridine dimethylphenylthiosemicarbazone Chemical class 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 241000193755 Bacillus cereus Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229910001961 silver nitrate Inorganic materials 0.000 description 2
- IGRCWJPBLWGNPX-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-(4-chlorophenyl)-n,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound C=1C=C(Cl)C=CC=1N(C)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl IGRCWJPBLWGNPX-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 235000003385 Diospyros ebenum Nutrition 0.000 description 1
- 241000792913 Ebenaceae Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229940006477 nitrate ion Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000013110 organic ligand Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 229940115939 shigella sonnei Drugs 0.000 description 1
- 229940100890 silver compound Drugs 0.000 description 1
- 150000003379 silver compounds Chemical class 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
- 150000003584 thiosemicarbazones Chemical class 0.000 description 1
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20120044A MD4252C1 (ro) | 2012-05-31 | 2012-05-31 | Catena-(µ-nitrato)[µ-(2-hidroxibenziliden)-4-prop-2-en-1-iltiosemicarbazon-S]argint cu activitate antimicrobiană faţă de bacteriile Salmonella abony |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20120044A MD4252C1 (ro) | 2012-05-31 | 2012-05-31 | Catena-(µ-nitrato)[µ-(2-hidroxibenziliden)-4-prop-2-en-1-iltiosemicarbazon-S]argint cu activitate antimicrobiană faţă de bacteriile Salmonella abony |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4252B1 MD4252B1 (en) | 2013-10-31 |
| MD4252C1 true MD4252C1 (ro) | 2014-05-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20120044A MD4252C1 (ro) | 2012-05-31 | 2012-05-31 | Catena-(µ-nitrato)[µ-(2-hidroxibenziliden)-4-prop-2-en-1-iltiosemicarbazon-S]argint cu activitate antimicrobiană faţă de bacteriile Salmonella abony |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4252C1 (mo) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU979359A1 (ru) * | 1981-07-20 | 1982-12-07 | Ордена Трудового Красного Знамени Институт Химии Ан Мсср | Производные @ -оксо-бис-([S-алкил-N @ ,N @ -ди(салицилиден)тиосемикарбазидато]железа(ш))и способ их получени |
| MD195B1 (ro) * | 1994-12-05 | 1995-05-31 | Univ De Stat De Medicina N Tes | Complexurile cuprului cu proprietati antistafilococice |
| MD1650F1 (en) * | 1999-12-06 | 2001-04-30 | Univ Nicolae Testemitanu | 3,5-Dibromsalicylidenethiosemicarbazidopyridinecopper possessing antistaphylococcia and antistreptococcia activity |
| MD1812B1 (en) * | 2000-12-29 | 2001-12-31 | Univ Nicolae Testemitanu | Copper complexes as bacteria and fungi inhibitors |
| MD2003B1 (en) * | 2001-01-10 | 2002-09-30 | Univ Nicolae Testemitanu | Copper chelate compounds(II) with antimicrobial and antimycotic activity |
| MD2942B2 (en) * | 2004-04-27 | 2005-12-31 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Di(-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper) |
| MD3032F1 (ro) * | 2005-10-31 | 2006-04-30 | Universitatea De Stat Din Moldova | Naftalidentiosemicarbazidati de cupru(II) care contin sulfanilamide |
| MD3124B1 (ro) * | 2005-05-25 | 2006-08-31 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Salicilidentiosemicarbazidati de cupru(II)care contin sulfanilamide |
| MD4112B1 (en) * | 2010-05-17 | 2011-05-31 | Univ De Stat Din Moldova | Coordinative compounds of copper with 4-(dimethylphenyl)-thiosemicarbazones of 2-formylpyridine |
-
2012
- 2012-05-31 MD MDA20120044A patent/MD4252C1/ro not_active IP Right Cessation
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU979359A1 (ru) * | 1981-07-20 | 1982-12-07 | Ордена Трудового Красного Знамени Институт Химии Ан Мсср | Производные @ -оксо-бис-([S-алкил-N @ ,N @ -ди(салицилиден)тиосемикарбазидато]железа(ш))и способ их получени |
| MD195B1 (ro) * | 1994-12-05 | 1995-05-31 | Univ De Stat De Medicina N Tes | Complexurile cuprului cu proprietati antistafilococice |
| MD1650F1 (en) * | 1999-12-06 | 2001-04-30 | Univ Nicolae Testemitanu | 3,5-Dibromsalicylidenethiosemicarbazidopyridinecopper possessing antistaphylococcia and antistreptococcia activity |
| MD1812B1 (en) * | 2000-12-29 | 2001-12-31 | Univ Nicolae Testemitanu | Copper complexes as bacteria and fungi inhibitors |
| MD2003B1 (en) * | 2001-01-10 | 2002-09-30 | Univ Nicolae Testemitanu | Copper chelate compounds(II) with antimicrobial and antimycotic activity |
| MD2942B2 (en) * | 2004-04-27 | 2005-12-31 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Di(-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper) |
| MD3124B1 (ro) * | 2005-05-25 | 2006-08-31 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Salicilidentiosemicarbazidati de cupru(II)care contin sulfanilamide |
| MD3032F1 (ro) * | 2005-10-31 | 2006-04-30 | Universitatea De Stat Din Moldova | Naftalidentiosemicarbazidati de cupru(II) care contin sulfanilamide |
| MD4112B1 (en) * | 2010-05-17 | 2011-05-31 | Univ De Stat Din Moldova | Coordinative compounds of copper with 4-(dimethylphenyl)-thiosemicarbazones of 2-formylpyridine |
Also Published As
| Publication number | Publication date |
|---|---|
| MD4252B1 (en) | 2013-10-31 |
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| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |