MD384C2 - Procedeu de obţinere a derivaţilor aminotiazolici ai cefalosporinei - Google Patents
Procedeu de obţinere a derivaţilor aminotiazolici ai cefalosporineiInfo
- Publication number
- MD384C2 MD384C2 MD94-0373A MD940373A MD384C2 MD 384 C2 MD384 C2 MD 384C2 MD 940373 A MD940373 A MD 940373A MD 384 C2 MD384 C2 MD 384C2
- Authority
- MD
- Moldova
- Prior art keywords
- cephalosporin
- activation
- alkyl
- acid
- group
- Prior art date
Links
- -1 cephalosporin aminothiazole derivatives Chemical class 0.000 title abstract 6
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 230000004913 activation Effects 0.000 abstract 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000005494 condensation Effects 0.000 abstract 2
- 238000009833 condensation Methods 0.000 abstract 2
- 229910052700 potassium Inorganic materials 0.000 abstract 2
- 239000011591 potassium Substances 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000001720 action spectrum Methods 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 244000144987 brood Species 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
Derivaţii aminotiazolilici ai cefalosporinei manifestă o acţiune bactericidă puternică şi se utilizează în medicină ca antibiotice actuale cu un spectru larg de acţiune. Procedeu de obţinere a derivaţilor aminotiazolilici ai cefalosporinei cu formula generală:în care X reprezintă atomul de hidrogen, acetoxigrupa, grupa piridilică nesubstituită, grupa 2-metil-5,6-dioxo-1,2,5,6-tetrahidro-1,2,4-triazintiolică-3, R1 reprezintă grupa metilică sau alcanocarboxilică a acizilor inferiori cu 1-4 atomi de carbon, opţional sub formă de ester, de preferinţă ester terţ. butilic, R2 reprezintă atomul de hidrogen, sodiu sau potasiu, grupa amonică, sililică, alchilică sau alchilarilică inferioară, prin activarea cu acid Z-2-/2-amino-tiazolil-4/-2-alcoxiiminoacetic şi condensarea formei active obţinute a acidului cu săruri de sodiu, potasiu, amoniu sau cu ester sililic, alchilic sau alchilarilic cu 1-20 atomi de carbon, derivaţi ai acidului 7-aminocefalosporinic, activarea acidului Z-2-/2-aminotiazolil-4/-2-alcoxiiminoacetic se realizează în nitrilul alifatic prin tratarea cu un reagent, obţinut din dimetilformamidă şi clorură de tionil, la temperatura 273-233oK, după ce forma activă astfel preparată se supune condensării; drept nitril alifatic se foloseşte acetonitrilul şi activarea se efectuează la temperatura 253-2480K.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD94-0373A MD384C2 (ro) | 1994-11-11 | 1994-11-11 | Procedeu de obţinere a derivaţilor aminotiazolici ai cefalosporinei |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD94-0373A MD384C2 (ro) | 1994-11-11 | 1994-11-11 | Procedeu de obţinere a derivaţilor aminotiazolici ai cefalosporinei |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD384C2 true MD384C2 (ro) | 1996-07-31 |
Family
ID=62142683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0373A MD384C2 (ro) | 1994-11-11 | 1994-11-11 | Procedeu de obţinere a derivaţilor aminotiazolici ai cefalosporinei |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD384C2 (ro) |
-
1994
- 1994-11-11 MD MD94-0373A patent/MD384C2/ro unknown
Non-Patent Citations (1)
| Title |
|---|
| Brevet nr.2053893, GB, Int.cl. C 07 D 501/20, 1981. * |
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