MD384C2 - Process for cephalosporin aminothiazole derivatives obtaining - Google Patents
Process for cephalosporin aminothiazole derivatives obtainingInfo
- Publication number
- MD384C2 MD384C2 MD94-0373A MD940373A MD384C2 MD 384 C2 MD384 C2 MD 384C2 MD 940373 A MD940373 A MD 940373A MD 384 C2 MD384 C2 MD 384C2
- Authority
- MD
- Moldova
- Prior art keywords
- cephalosporin
- activation
- alkyl
- acid
- group
- Prior art date
Links
- -1 cephalosporin aminothiazole derivatives Chemical class 0.000 title abstract 6
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 230000004913 activation Effects 0.000 abstract 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000005494 condensation Effects 0.000 abstract 2
- 238000009833 condensation Methods 0.000 abstract 2
- 229910052700 potassium Inorganic materials 0.000 abstract 2
- 239000011591 potassium Substances 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000001720 action spectrum Methods 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 244000144987 brood Species 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
The cephalosporin aminothiazole derivatives reveal a strong bactericidal action and are used in medicine as up-to-date antibiotics with a brood action spectrum. The process for cephalosporin aminonothiazole derivatives obtaining is of general formula:wherein X means hydrogen atom, acetoxy group, unsubstituted pyridyl group, 2-methyl-5,6-dioxo-1,2,5,6 - tetrahydro - 1,2,4-triazine-thiol-3-group,R1 - means methyl or alkane carboxyl groupof lower acids with 1-4 hydrogen atoms, possibly in the form of alcohol ester, preferably tret butyl ester,R2 - means hydrogen atom, natrium or potassium, ammonium, silyle, alkyl or lower alkylaryl group, by activation of Z-2-(2-aminothiazole-4)-2-alcoxyimuno-acetic acid and condensation of the obtained acid active form with natrium, potassium, ammonium salts or silyle, alkyl or alkyl-aryl esters with 1-20 hydrogen atoms of 7 - aminocephalosporin acid derivatives, the activation of Z-2-(2-amino-thiazole-4)-2-alcoxyimunoacetic acid is produced into the aliphatic nitrile by reagent treatment, obtained of dimethylformamide and thionyl chloride at a temperature of 273 - 233°K, after that the prepares so active form is exposed to condensation; as aliphatic nitrile is used acetonitrile and the activation is produced at a temperature of 253-248°K.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD94-0373A MD384C2 (en) | 1994-11-11 | 1994-11-11 | Process for cephalosporin aminothiazole derivatives obtaining |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD94-0373A MD384C2 (en) | 1994-11-11 | 1994-11-11 | Process for cephalosporin aminothiazole derivatives obtaining |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD384C2 true MD384C2 (en) | 1996-07-31 |
Family
ID=62142683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0373A MD384C2 (en) | 1994-11-11 | 1994-11-11 | Process for cephalosporin aminothiazole derivatives obtaining |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD384C2 (en) |
-
1994
- 1994-11-11 MD MD94-0373A patent/MD384C2/en unknown
Non-Patent Citations (1)
| Title |
|---|
| Brevet nr.2053893, GB, Int.cl. C 07 D 501/20, 1981. * |
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