MD3443010T2 - Noi anticorpi anti-SIRPa și aplicațiile lor terapeutice - Google Patents
Noi anticorpi anti-SIRPa și aplicațiile lor terapeutice Download PDFInfo
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- MD3443010T2 MD3443010T2 MDE20190221T MDE20190221T MD3443010T2 MD 3443010 T2 MD3443010 T2 MD 3443010T2 MD E20190221 T MDE20190221 T MD E20190221T MD E20190221 T MDE20190221 T MD E20190221T MD 3443010 T2 MD3443010 T2 MD 3443010T2
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| EP4438626A3 (en) * | 2016-04-14 | 2024-12-04 | OSE Immunotherapeutics | New anti-sirpa antibodies and their therapeutic applications |
| JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
| MX2020000957A (es) * | 2017-07-26 | 2020-07-22 | Forty Seven Inc | Anticuerpos anti-sirp-alfa y metodos relacionados. |
| WO2019073080A1 (en) | 2017-10-13 | 2019-04-18 | Ose Immunotherapeutics | ANTI-SIRPA MODIFIED ANTIBODIES AND USES THEREOF |
| KR20210006338A (ko) | 2018-03-13 | 2021-01-18 | 오제 이뮈노테라프틱스 | 항-인간 SIRPa v1 항체의 이용 및 항-SIRPa v1 항체를 생산하는 방법 |
| BR112020018927A2 (pt) | 2018-03-21 | 2021-01-05 | ALX Oncology Inc. | Anticorpos contra proteína alfa reguladora de sinal e métodos de uso |
| MY205933A (en) | 2018-09-27 | 2024-11-21 | Celgene Corp | Sirp-alpha binding proteins and methods of use thereof |
| US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
| CN118178645A (zh) | 2019-10-18 | 2024-06-14 | 四十七公司 | 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法 |
| US20210147568A1 (en) | 2019-10-31 | 2021-05-20 | Forty Seven, Inc. | Anti-cd47 based treatment of blood cancer |
| CN112574310B (zh) * | 2020-12-11 | 2023-05-05 | 浙江博锐生物制药有限公司 | 抗SIRPα抗体及其用途 |
| KR102896511B1 (ko) * | 2022-09-07 | 2025-12-08 | 주식회사 시프트바이오 | SIRPα 변이체에 특이적으로 결합하는 항체 |
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| US20100215640A1 (en) | 2003-04-24 | 2010-08-26 | The University Of North Carolina At Chapel Hill | Method for inhibiting cellular activation by insulin-like growth factor-1 |
| JP3936673B2 (ja) * | 2003-06-02 | 2007-06-27 | 国立大学法人群馬大学 | Ｃｄ４７部分ペプチドと抗ｓｈｐｓ−１モノクロナール抗体 |
| RS54271B1 (sr) | 2005-07-01 | 2016-02-29 | E. R. Squibb & Sons, L.L.C. | Humana monoklonska antitela za ligand programirane smrti 1 (pd-l1) |
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| EP2573112A1 (en) | 2007-10-11 | 2013-03-27 | The Hospital For Sick Children | Modulation of sirpa - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor |
| EP2620157A3 (en) | 2007-10-12 | 2013-10-16 | Massachusetts Institute of Technology | Vaccine nanotechnology |
| DK3056515T4 (da) | 2008-01-15 | 2025-10-20 | Univ Leland Stanford Junior | Fremgangsmåde til at manipulere fagocytose medieret af cd47 |
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| PL2429574T3 (pl) | 2009-05-15 | 2015-12-31 | Univ Health Network | Kompozycje i sposoby leczenia nowotworów hematologicznych celujące w oddziaływanie SIRP-CD47 |
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| RS61033B1 (sr) | 2011-11-28 | 2020-12-31 | Merck Patent Gmbh | Antitela na pd-l1 i njihova upotreba |
| CN104136037B (zh) | 2012-01-17 | 2018-02-23 | 小利兰·斯坦福大学托管委员会 | 高亲和力SIRP‑α试剂 |
| BR112015018851A2 (pt) | 2013-02-06 | 2017-07-18 | Inhibrx Llc | anticorpos cd47 de não depleção de plaquetas e de não depleção de células vermelhas do sangue, e métodos de uso dos mesmos |
| US10570204B2 (en) | 2013-09-26 | 2020-02-25 | The Medical College Of Wisconsin, Inc. | Methods for treating hematologic cancers |
| SG11201607143UA (en) * | 2014-03-11 | 2016-09-29 | Univ Leland Stanford Junior | Anti sirp-alpha antibodies and bi-specific macrophage enhancing antibodies |
| CN105085679B (zh) * | 2014-04-25 | 2019-01-11 | 上海津曼特生物科技有限公司 | 全人源抗rankl抗体 |
| EP3012271A1 (en) | 2014-10-24 | 2016-04-27 | Effimune | Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases |
| US10618976B2 (en) | 2015-06-16 | 2020-04-14 | The Board Of Trustees Of The Leland Stanford Junior University | SIRP-α agonist antibody |
| EP4186927B1 (en) | 2015-10-21 | 2025-04-23 | Ose Immunotherapeutics | Methods and compositions for modifying macrophage polarization into pro-inflammatory cells to treat cancer |
| CN109071664B (zh) | 2016-04-14 | 2023-02-21 | Ose免疫疗法 | 新型抗-SIRPa抗体及其治疗应用 |
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| AU2017371070B2 (en) | 2016-12-09 | 2025-01-02 | Alector Llc | Anti-SIRP-alpha antibodies and methods of use thereof |
| CA3058134A1 (en) * | 2017-04-13 | 2018-10-18 | Aduro Biotech Holdings, Europe B.V. | Anti-sirp alpha antibodies |
| HRP20240924T1 (hr) | 2017-05-16 | 2024-10-11 | Byondis B.V. | Anti - sirpalpha antitijela |
| MX2020000957A (es) | 2017-07-26 | 2020-07-22 | Forty Seven Inc | Anticuerpos anti-sirp-alfa y metodos relacionados. |
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| KR20210006338A (ko) | 2018-03-13 | 2021-01-18 | 오제 이뮈노테라프틱스 | 항-인간 SIRPa v1 항체의 이용 및 항-SIRPa v1 항체를 생산하는 방법 |
| BR112020018927A2 (pt) | 2018-03-21 | 2021-01-05 | ALX Oncology Inc. | Anticorpos contra proteína alfa reguladora de sinal e métodos de uso |
| TW202448946A (zh) | 2018-05-25 | 2024-12-16 | 美商阿列克特有限責任公司 | 抗-sirpa 抗體及其使用方法 |
| BR112020023322A2 (pt) | 2018-07-10 | 2021-02-02 | National University Corporation Kobe University | anticorpo anti-sirpalfa |
| CA3108795A1 (en) | 2018-08-08 | 2020-02-13 | Orionis Biosciences, Inc. | Sirp1a targeted chimeric proteins and uses thereof |
| MY205933A (en) | 2018-09-27 | 2024-11-21 | Celgene Corp | Sirp-alpha binding proteins and methods of use thereof |
| BR112021009325A2 (pt) | 2018-11-14 | 2021-09-14 | Arch Oncology, Inc. | Anticorpo monoclonal, ou fragmento de ligação ao antígeno do mesmo; anticorpo biespecífico; método para prevenir ou tratar um câncer suscetível em um ser humano; método de ensaio de expressão de sirp¿ em células tumorais e/ou imunes; e; composição farmacêutica |
| MX2021005761A (es) | 2018-11-15 | 2021-08-11 | Byondis Bv | Anticuerpos anti-proteína alfa reguladora de señal (anti-sirpalfa) humanizados. |
| WO2020180811A1 (en) | 2019-03-04 | 2020-09-10 | Qilu Puget Sound Biotherapeutics Corporation | Anti-sirp-alpha antibodies |
| US20210347908A1 (en) | 2019-08-20 | 2021-11-11 | Elpiscience (Suzhou) Biopharma, Ltd. | Novel anti-sirpa antibodies |
| CN111635458A (zh) | 2020-03-20 | 2020-09-08 | 上海健信生物医药科技有限公司 | 靶向Sirpα的抗体或其抗原结合片段及其制备和应用 |
| CN112010979B (zh) | 2020-08-21 | 2022-05-10 | 博奥信生物技术（南京）有限公司 | 一种抗人SIRPα单克隆抗体及其用途 |
| CN111995682B (zh) | 2020-08-21 | 2022-05-10 | 博奥信生物技术（南京）有限公司 | 抗人SIRPα单克隆抗体及其用途 |
| CN112574310B (zh) | 2020-12-11 | 2023-05-05 | 浙江博锐生物制药有限公司 | 抗SIRPα抗体及其用途 |
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2017
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2018
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2022
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2025
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