MD332C2 - Способ получения цис-2-(1Н-1,2,4-триазол-1-ил-метил)-2-(галогенфенил)-3-(галогенфенил)-оксирана - Google Patents

Способ получения цис-2-(1Н-1,2,4-триазол-1-ил-метил)-2-(галогенфенил)-3-(галогенфенил)-оксирана

Info

Publication number
MD332C2
MD332C2 MD95-0016A MD950016A MD332C2 MD 332 C2 MD332 C2 MD 332C2 MD 950016 A MD950016 A MD 950016A MD 332 C2 MD332 C2 MD 332C2
Authority
MD
Moldova
Prior art keywords
halogenphenyl
triazole
oxirane
methyl
restorer
Prior art date
Application number
MD95-0016A
Other languages
English (en)
Romanian (ro)
Other versions
MD332B1 (ro
Inventor
Hickmann Eckhard
Rainer Seele
Kober Reiner
Heinz Isak
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of MD332B1 publication Critical patent/MD332B1/xx
Publication of MD332C2 publication Critical patent/MD332C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение касается способа получения цис-2-(1Н-1,2,4-триазол-1-ил-метил)-2-(галогенфенил)-3-(галогенфенил)-оксирана формулы (1)Целью изобретения является повышение выхода целевого продукта и уменьшение затрат на очистку.Способ осуществляется путем эпоксидирования Z-3-(1Н-1,2,4-триазол-1-ил)-2-(галогенфенил)-1-(галогенфенил)-пропена пермалеиновой кислотой с последующим восстановлением. В качестве восстановителя используется гидросульфит натрия, дитионит натрия или тиосульфат натрия или водород в присутствии никеля Ренея. Восстановительдобавляют к реакционной смеси в количестве,превышающем количество, необходимое для разрушения возможно имеющейся пермалеиновой кислоты.
MD95-0016A 1989-11-04 1994-12-13 Способ получения цис-2-(1Н-1,2,4-триазол-1-ил-метил)-2-(галогенфенил)-3-(галогенфенил)-оксирана MD332C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3936821A DE3936821A1 (de) 1989-11-04 1989-11-04 Verfahren zur herstellung von cis-2-(1h-1,2,4-triazol-1-ylmethyl)-2- (halogenphenyl)-3-(halogenphenyl)-oxiran
SU904831490A RU2071473C1 (ru) 1989-11-04 1990-11-02 Способ получения цис-2-(1н-1,2,4-триазол-1-ил-метил)-2-(галогенфенил)-3-(галогенфенил)-оксирана

Publications (2)

Publication Number Publication Date
MD332B1 MD332B1 (ro) 1995-11-30
MD332C2 true MD332C2 (ru) 1996-03-31

Family

ID=6392916

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0016A MD332C2 (ru) 1989-11-04 1994-12-13 Способ получения цис-2-(1Н-1,2,4-триазол-1-ил-метил)-2-(галогенфенил)-3-(галогенфенил)-оксирана

Country Status (10)

Country Link
EP (1) EP0427061B1 (ru)
JP (1) JP2983054B2 (ru)
KR (1) KR0157314B1 (ru)
AT (1) ATE116315T1 (ru)
CA (1) CA2028650C (ru)
DE (2) DE3936821A1 (ru)
DK (1) DK0427061T3 (ru)
ES (1) ES2066089T3 (ru)
MD (1) MD332C2 (ru)
RU (1) RU2071473C1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ272586A (en) * 1995-07-17 1996-10-28 Apotex Inc Process for preparing fluconazole and triazolylepoxypropane precursors
EP1517906B1 (de) * 2002-06-24 2007-03-28 Basf Aktiengesellschaft Verfahren zur herstellung von 1,2,4-triazolylmethyl-oxiranen
EP2746275A1 (en) 2012-12-19 2014-06-25 Basf Se New substituted triazoles and imidazoles and their use as fungicides
CN103936723B (zh) * 2013-01-23 2016-06-29 沈阳中化农药化工研发有限公司 一种催化三唑烯环氧化制备氟环唑的方法
CN111848504A (zh) * 2019-04-29 2020-10-30 沈阳中化农药化工研发有限公司 一种锰催化剂及其催化三唑烯环氧化制备氟环唑的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2952755A1 (de) * 1979-12-29 1981-07-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von oxiranen
CA1271764A (en) * 1985-03-29 1990-07-17 Stefan Karbach Azolylmethyloxiranes, their preparation and their use as crop protection agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cererea nr. 3218129, DE, Int. Cl. C 07 D 405 /06, 1983. *

Also Published As

Publication number Publication date
RU2071473C1 (ru) 1997-01-10
EP0427061A3 (en) 1992-01-02
DE3936821A1 (de) 1991-05-08
JPH03153682A (ja) 1991-07-01
KR0157314B1 (ko) 1998-11-16
ES2066089T3 (es) 1995-03-01
CA2028650C (en) 2003-09-30
EP0427061A2 (de) 1991-05-15
ATE116315T1 (de) 1995-01-15
KR910009695A (ko) 1991-06-28
CA2028650A1 (en) 1991-05-05
JP2983054B2 (ja) 1999-11-29
DE59008135D1 (de) 1995-02-09
DK0427061T3 (da) 1995-02-27
MD332B1 (ro) 1995-11-30
EP0427061B1 (de) 1994-12-28

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20101102

KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees